Intracranial Involvement Of Multiple Myeloma
OBJECTIVE: Multiple myeloma is usually restricted to the bone marrow. Central nervous system involvement is uncommon and can be observed in approximately 1% of the multiple myeloma patients. OBJECTIVES: We aimed to demonstrate brain magnetic resonance patterns in patients with multiple myeloma with...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Galenos Yayinevi
2008-10-01
|
| Series: | Türk Nöroloji Dergisi |
| Subjects: | |
| Online Access: | http://www.tjn.org.tr/jvi.aspx?pdir=tjn&plng=eng&un=TJN-30502 |
| _version_ | 1797919177147678720 |
|---|---|
| author | Özlem Alkan Ebru Kızılkılıç Tülin Yıldırım Mutlu Kasar Osman Kızılkılıç Mahmut Yeral Süheyl Asma Semih Giray Hakan Özdoğu |
| author_facet | Özlem Alkan Ebru Kızılkılıç Tülin Yıldırım Mutlu Kasar Osman Kızılkılıç Mahmut Yeral Süheyl Asma Semih Giray Hakan Özdoğu |
| author_sort | Özlem Alkan |
| collection | DOAJ |
| description | OBJECTIVE: Multiple myeloma is usually restricted to the bone marrow. Central nervous system involvement is uncommon and can be observed in approximately 1% of the multiple myeloma patients. OBJECTIVES: We aimed to demonstrate brain magnetic resonance patterns in patients with multiple myeloma with neurologic symptoms and the literature is reviewed.
METHODS: We retrospectively studied 39 patients with multiple myeloma with neurologic symptoms. All the patients underwent classic and contrast enhanced brain MR examination.
RESULTS: Patients presented with the following symptoms: impaired consciousness (n=8, 20.5%), headache (n=6, 15.3%), hemiparesis (n=2, 5.1%), aphasia (n=6, 15.3%), scalp swelling (n=2, 5.1%), visual loss (n=1, 2.5%), seizure (n=2, 5.1%), vertigo (n=4, 10.2%), ophthalmoplegia (n=4, 10.2%), meningeal irritation findings (n=2, 5.1%), and orientation disorder (n=2, 5.1%). Among 39 patients with multiple myeloma, 14 (35.8%) had ischemic lesions, 14 (35.8%) had calvarial diploic metastases, 5 (12.8%) had dura mater mass, 4 (10.2%) had dura mater involvement, 2 (5.1%) had sinonasal mass, 1 had cavernous sinus and orbital apex mass, 1 (2.5%) had leptomeningeal involvement, 1 (2.5%) had intraorbital mass, 3 (7.6%) had clivus mass, 1 (2.5%) had optic neuritis, 1 (2.5%) had central pontine myelinolysis and 2 (5.1%) had meningitis. Examination of the cerebrospinal fluid was performed in 6 patients. Cerebrospinal fluid studies showed malignant plasma cells in 1 patient with leptomeningeal contrast enhancement. Despite serial cerebrospinal fluid examination, plasma cells in cerebrospinal fluid were not showed in 2 patients with dura mater involvement. Two patients had menengitis.
CONCLUSION: Involvement of the central nervous system in multiple myeloma is very uncommon. The occurrence of neurological symptoms in a patient with myeloma requires an accurate evaluation with MR and lumbar puncture to detect a possible meningeal or cerebral involvement, when metabolic factors (hypercalcemia,drug toxicity, uremia), hyperviscosity, or medullary compression can be excluded |
| first_indexed | 2024-04-10T13:41:26Z |
| format | Article |
| id | doaj.art-94cd5292b545453fa1641f0c3919c800 |
| institution | Directory Open Access Journal |
| issn | 1301-062X 1309-2545 |
| language | English |
| last_indexed | 2024-04-10T13:41:26Z |
| publishDate | 2008-10-01 |
| publisher | Galenos Yayinevi |
| record_format | Article |
| series | Türk Nöroloji Dergisi |
| spelling | doaj.art-94cd5292b545453fa1641f0c3919c8002023-02-15T16:11:08ZengGalenos YayineviTürk Nöroloji Dergisi1301-062X1309-25452008-10-01145328332Intracranial Involvement Of Multiple MyelomaÖzlem Alkan0Ebru Kızılkılıç1Tülin Yıldırım2Mutlu Kasar3Osman Kızılkılıç4Mahmut Yeral5Süheyl Asma6Semih Giray7Hakan Özdoğu8Department Of Radiology, Baskent University, Faculty Of Medicine, Adana, TurkeyDepartment Of Haematology, Baskent University, Faculty Of Medicine, Adana, TurkeyDepartment Of Radiology, Baskent University, Faculty Of Medicine, Adana, TurkeyDepartment Of Haematology, Baskent University, Faculty Of Medicine, Adana, TurkeyDepartment Of Radiology, Baskent University, Faculty Of Medicine, Adana, TurkeyDepartment Of Haematology, Baskent University, Faculty Of Medicine, Adana, TurkeyDepartment Of Haematology, Baskent University, Faculty Of Medicine, Adana, TurkeyDepartment Of Neurology, Baskent University, Faculty Of Medicine, Adana, TurkeyDepartment Of Haematology, Baskent University, Faculty Of Medicine, Adana, TurkeyOBJECTIVE: Multiple myeloma is usually restricted to the bone marrow. Central nervous system involvement is uncommon and can be observed in approximately 1% of the multiple myeloma patients. OBJECTIVES: We aimed to demonstrate brain magnetic resonance patterns in patients with multiple myeloma with neurologic symptoms and the literature is reviewed. METHODS: We retrospectively studied 39 patients with multiple myeloma with neurologic symptoms. All the patients underwent classic and contrast enhanced brain MR examination. RESULTS: Patients presented with the following symptoms: impaired consciousness (n=8, 20.5%), headache (n=6, 15.3%), hemiparesis (n=2, 5.1%), aphasia (n=6, 15.3%), scalp swelling (n=2, 5.1%), visual loss (n=1, 2.5%), seizure (n=2, 5.1%), vertigo (n=4, 10.2%), ophthalmoplegia (n=4, 10.2%), meningeal irritation findings (n=2, 5.1%), and orientation disorder (n=2, 5.1%). Among 39 patients with multiple myeloma, 14 (35.8%) had ischemic lesions, 14 (35.8%) had calvarial diploic metastases, 5 (12.8%) had dura mater mass, 4 (10.2%) had dura mater involvement, 2 (5.1%) had sinonasal mass, 1 had cavernous sinus and orbital apex mass, 1 (2.5%) had leptomeningeal involvement, 1 (2.5%) had intraorbital mass, 3 (7.6%) had clivus mass, 1 (2.5%) had optic neuritis, 1 (2.5%) had central pontine myelinolysis and 2 (5.1%) had meningitis. Examination of the cerebrospinal fluid was performed in 6 patients. Cerebrospinal fluid studies showed malignant plasma cells in 1 patient with leptomeningeal contrast enhancement. Despite serial cerebrospinal fluid examination, plasma cells in cerebrospinal fluid were not showed in 2 patients with dura mater involvement. Two patients had menengitis. CONCLUSION: Involvement of the central nervous system in multiple myeloma is very uncommon. The occurrence of neurological symptoms in a patient with myeloma requires an accurate evaluation with MR and lumbar puncture to detect a possible meningeal or cerebral involvement, when metabolic factors (hypercalcemia,drug toxicity, uremia), hyperviscosity, or medullary compression can be excludedhttp://www.tjn.org.tr/jvi.aspx?pdir=tjn&plng=eng&un=TJN-30502multiple myelomacentral nervous system involvementMR |
| spellingShingle | Özlem Alkan Ebru Kızılkılıç Tülin Yıldırım Mutlu Kasar Osman Kızılkılıç Mahmut Yeral Süheyl Asma Semih Giray Hakan Özdoğu Intracranial Involvement Of Multiple Myeloma Türk Nöroloji Dergisi multiple myeloma central nervous system involvement MR |
| title | Intracranial Involvement Of Multiple Myeloma |
| title_full | Intracranial Involvement Of Multiple Myeloma |
| title_fullStr | Intracranial Involvement Of Multiple Myeloma |
| title_full_unstemmed | Intracranial Involvement Of Multiple Myeloma |
| title_short | Intracranial Involvement Of Multiple Myeloma |
| title_sort | intracranial involvement of multiple myeloma |
| topic | multiple myeloma central nervous system involvement MR |
| url | http://www.tjn.org.tr/jvi.aspx?pdir=tjn&plng=eng&un=TJN-30502 |
| work_keys_str_mv | AT ozlemalkan intracranialinvolvementofmultiplemyeloma AT ebrukızılkılıc intracranialinvolvementofmultiplemyeloma AT tulinyıldırım intracranialinvolvementofmultiplemyeloma AT mutlukasar intracranialinvolvementofmultiplemyeloma AT osmankızılkılıc intracranialinvolvementofmultiplemyeloma AT mahmutyeral intracranialinvolvementofmultiplemyeloma AT suheylasma intracranialinvolvementofmultiplemyeloma AT semihgiray intracranialinvolvementofmultiplemyeloma AT hakanozdogu intracranialinvolvementofmultiplemyeloma |