Mechanistic Insight into the Mode of Action of Acid β-Glucosidase Enhancer Ambroxol

Mechanistic Insight into the Mode of Action of Acid β-Glucosidase Enhancer Ambroxol

Ambroxol (ABX) is a mucolytic agent used for the treatment of respiratory diseases. Bioactivity has been demonstrated as an enhancement effect on lysosomal acid β-glucosidase (β-Glu) activity in Gaucher disease (GD). The positive effects observed have been attributed to a mechanism of action similar...

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Bibliographic Details
Main Authors: Supansa Pantoom, Larissa Hules, Christopher Schöll, Andranik Petrosyan, Maria Monticelli, Jola Pospech, Maria Vittoria Cubellis, Andreas Hermann, Jan Lukas
Format: Article
Language:English
Published: MDPI AG 2022-03-01
Series:International Journal of Molecular Sciences
Subjects:
Gaucher disease
small molecule therapy
pharmacological chaperone
drug repositioning
lysosomal storage disease
rare disease
Online Access:https://www.mdpi.com/1422-0067/23/7/3536

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