Lack of Renal Tubular Glucocorticoid Receptor Decreases the Thiazide-Sensitive Na+/Cl– Cotransporter NCC and Transiently Affects Sodium Handling

Lack of Renal Tubular Glucocorticoid Receptor Decreases the Thiazide-Sensitive Na+/Cl– Cotransporter NCC and Transiently Affects Sodium Handling

Chronic glucocorticoid infusion impairs NCC activity and induces a non-dipping profile in mice, suggesting that glucocorticoids are essential for daily blood pressure variations. In this paper, we studied mice lacking the renal tubular glucocorticoid receptor (GR) in adulthood (GR knockouts, Nr3c1Pa...

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Bibliographic Details
Main Authors: Jérémie Canonica, Simona Frateschi, Emilie Boscardin, Anna Ebering, Chloé Sergi, Yannick Jäger, Thibaud Peyrollaz, Anne-Marie Mérillat, Marc Maillard, Petra Klusonova, Alex Odermatt, Robert Koesters, Anne Debonneville, Olivier Staub, Sophia N. Verouti, Edith Hummler
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-08-01
Series:Frontiers in Physiology
Subjects:
glucocorticoid receptor
sodium transport
sodium and hydrogen exchanger 3
Na+-K+-Cl– cotransporter
thiazide-sensitive Na+/Cl– cotransporter
blood pressure
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2019.00989/full

Internet

https://www.frontiersin.org/article/10.3389/fphys.2019.00989/full

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