Avian oncogenic herpesvirus antagonizes the cGAS-STING DNA-sensing pathway to mediate immune evasion.

Avian oncogenic herpesvirus antagonizes the cGAS-STING DNA-sensing pathway to mediate immune evasion.

The cellular DNA sensor cGMP-AMP synthase (cGAS) detects cytosolic viral DNA via the stimulator of interferon genes (STING) to initiate innate antiviral response. Herpesviruses are known to target key immune signaling pathways to persist in an immune-competent host. Marek's disease virus (MDV),...

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Bibliographic Details
Main Authors: Kai Li, Yongzhen Liu, Zengkun Xu, Yu Zhang, Dan Luo, Yulong Gao, Yingjuan Qian, Chenyi Bao, Changjun Liu, Yanping Zhang, Xiaole Qi, Hongyu Cui, Yongqiang Wang, Li Gao, Xiaomei Wang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-09-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1007999

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https://doi.org/10.1371/journal.ppat.1007999

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