Temperature and Stretching Effects on Complementarity Determining Regions (CDRs) Conformation and Stability of Nimotuzumab F(ab)-Fragment

Temperature and Stretching Effects on Complementarity Determining Regions (CDRs) Conformation and Stability of Nimotuzumab F(ab)-Fragment

Nimotuzumab is a humanized monoclonal antibody (mAb), a potential anticancer against epidermal growth factor receptor (EGFR)overexpressed by glioma, head and neck, lung, ovarium, and colon cancers. The combination of its use with both external and internal beam radiotherapies showed improvement of t...

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Bibliographic Details
Main Authors: T.S. Humani, M.A. Martoprawiro, A. Mutalib
Format: Article
Language:English
Published: Center for Development of Nuclear Informatics, National Nuclear Energy Agency (BATAN) 2015-04-01
Series:Atom Indonesia
Subjects:
Nimotuzumab
F(ab)-Nimotuzumab
Complementarity Determining Regions (CDRs
Unfolding
Molecular Dynamics
Steered Molecular Dynamics
Online Access:http://aij.batan.go.id/index.php/aij/article/view/351

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