Innate Lymphoid Cells: Important Regulators of Host–Bacteria Interaction for Border Defense
Innate lymphoid cells (ILCs) are a recently discovered type of innate immune lymphocyte. They include three different groups classified by the nature of the transcription factors required for their development and by the cytokines they produce. ILCs mainly reside in tissues close to the mucosal barr...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2020-09-01
|
| Series: | Microorganisms |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-2607/8/9/1342 |
| _version_ | 1797554785433419776 |
|---|---|
| author | Katharina Beck Hiroshi Ohno Naoko Satoh-Takayama |
| author_facet | Katharina Beck Hiroshi Ohno Naoko Satoh-Takayama |
| author_sort | Katharina Beck |
| collection | DOAJ |
| description | Innate lymphoid cells (ILCs) are a recently discovered type of innate immune lymphocyte. They include three different groups classified by the nature of the transcription factors required for their development and by the cytokines they produce. ILCs mainly reside in tissues close to the mucosal barrier such as the respiratory and gastrointestinal tracts. Due to their close proximity to the mucosal surface, ILCs are exposed to a variety of both commensal and pathogenic bacteria. Under non-pathological conditions, ILCs have been shown to be important regulators for the maintenance of tissue homeostasis by mutual interactions with the microbiome. Besides these important functions at homeostasis, several studies have also provided emerging evidence that ILCs contribute to defense against pathogenic bacterial infection by responding rapidly to the pathogens as well as orchestrating other immune cells. In this review, we summarize recent advances in our understanding of the interactions of ILCs and bacteria, with special focus on the function of the different ILC subsets in bacterial infections. |
| first_indexed | 2024-03-10T16:37:01Z |
| format | Article |
| id | doaj.art-94d32f61eab24a0791d6d036e58fe07c |
| institution | Directory Open Access Journal |
| issn | 2076-2607 |
| language | English |
| last_indexed | 2024-03-10T16:37:01Z |
| publishDate | 2020-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Microorganisms |
| spelling | doaj.art-94d32f61eab24a0791d6d036e58fe07c2023-11-20T12:20:25ZengMDPI AGMicroorganisms2076-26072020-09-0189134210.3390/microorganisms8091342Innate Lymphoid Cells: Important Regulators of Host–Bacteria Interaction for Border DefenseKatharina Beck0Hiroshi Ohno1Naoko Satoh-Takayama2Laboratory for Intestinal Ecosystem, Center for Integrative Medical Sciences, RIKEN, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama 230-0045, JapanLaboratory for Intestinal Ecosystem, Center for Integrative Medical Sciences, RIKEN, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama 230-0045, JapanLaboratory for Intestinal Ecosystem, Center for Integrative Medical Sciences, RIKEN, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama 230-0045, JapanInnate lymphoid cells (ILCs) are a recently discovered type of innate immune lymphocyte. They include three different groups classified by the nature of the transcription factors required for their development and by the cytokines they produce. ILCs mainly reside in tissues close to the mucosal barrier such as the respiratory and gastrointestinal tracts. Due to their close proximity to the mucosal surface, ILCs are exposed to a variety of both commensal and pathogenic bacteria. Under non-pathological conditions, ILCs have been shown to be important regulators for the maintenance of tissue homeostasis by mutual interactions with the microbiome. Besides these important functions at homeostasis, several studies have also provided emerging evidence that ILCs contribute to defense against pathogenic bacterial infection by responding rapidly to the pathogens as well as orchestrating other immune cells. In this review, we summarize recent advances in our understanding of the interactions of ILCs and bacteria, with special focus on the function of the different ILC subsets in bacterial infections.https://www.mdpi.com/2076-2607/8/9/1342innate lymphoid cells (ILCs)bacterial infectionmucosal defensemicrobiotaintestinal homeostasis |
| spellingShingle | Katharina Beck Hiroshi Ohno Naoko Satoh-Takayama Innate Lymphoid Cells: Important Regulators of Host–Bacteria Interaction for Border Defense Microorganisms innate lymphoid cells (ILCs) bacterial infection mucosal defense microbiota intestinal homeostasis |
| title | Innate Lymphoid Cells: Important Regulators of Host–Bacteria Interaction for Border Defense |
| title_full | Innate Lymphoid Cells: Important Regulators of Host–Bacteria Interaction for Border Defense |
| title_fullStr | Innate Lymphoid Cells: Important Regulators of Host–Bacteria Interaction for Border Defense |
| title_full_unstemmed | Innate Lymphoid Cells: Important Regulators of Host–Bacteria Interaction for Border Defense |
| title_short | Innate Lymphoid Cells: Important Regulators of Host–Bacteria Interaction for Border Defense |
| title_sort | innate lymphoid cells important regulators of host bacteria interaction for border defense |
| topic | innate lymphoid cells (ILCs) bacterial infection mucosal defense microbiota intestinal homeostasis |
| url | https://www.mdpi.com/2076-2607/8/9/1342 |
| work_keys_str_mv | AT katharinabeck innatelymphoidcellsimportantregulatorsofhostbacteriainteractionforborderdefense AT hiroshiohno innatelymphoidcellsimportantregulatorsofhostbacteriainteractionforborderdefense AT naokosatohtakayama innatelymphoidcellsimportantregulatorsofhostbacteriainteractionforborderdefense |