Controlled Release of Flurbiprofen from 3D-Printed and Supercritical Carbon Dioxide Processed Methacrylate-Based Polymer
The ability to engineer and predict drug release behavior during treatment is critical to the design and implementation of effective drug delivery systems. In this study, a drug delivery system consisting of a methacrylate-based polymer and flurbiprofen was studied, and its release profile in a cont...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-04-01
|
| Series: | Pharmaceutics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1999-4923/15/4/1301 |
| _version_ | 1797603818426335232 |
|---|---|
| author | Truc T. Ngo Jae D. Kim |
| author_facet | Truc T. Ngo Jae D. Kim |
| author_sort | Truc T. Ngo |
| collection | DOAJ |
| description | The ability to engineer and predict drug release behavior during treatment is critical to the design and implementation of effective drug delivery systems. In this study, a drug delivery system consisting of a methacrylate-based polymer and flurbiprofen was studied, and its release profile in a controlled phosphate-buffered saline solution was characterized. The polymer, which was 3D printed and processed in supercritical carbon dioxide under different temperature and pressure settings, showed sustained drug release over a prolonged period. A computer algorithm was used to determine the drug release time duration before reaching steady state and the maximum drug release at steady state. Several empirical models were applied to fit the release kinetic data to gain information about the drug release mechanism. The diffusion coefficients for each system were also estimated using Fick’s law. Based on the results, the influence of supercritical carbon dioxide processing conditions on the diffusion behavior is interpreted, providing insights into the effective and tunable design of drug delivery systems for targeted treatment specifications. |
| first_indexed | 2024-03-11T04:37:27Z |
| format | Article |
| id | doaj.art-94d33308dafe4f3da4136dbe5142b7e0 |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-11T04:37:27Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-94d33308dafe4f3da4136dbe5142b7e02023-11-17T20:55:34ZengMDPI AGPharmaceutics1999-49232023-04-01154130110.3390/pharmaceutics15041301Controlled Release of Flurbiprofen from 3D-Printed and Supercritical Carbon Dioxide Processed Methacrylate-Based PolymerTruc T. Ngo0Jae D. Kim1Department of Industrial and Systems Engineering, Shiley-Marcos School of Engineering, University of San Diego, 5998 Alcala Park, San Diego, CA 92110, USADepartment of Industrial and Systems Engineering, Shiley-Marcos School of Engineering, University of San Diego, 5998 Alcala Park, San Diego, CA 92110, USAThe ability to engineer and predict drug release behavior during treatment is critical to the design and implementation of effective drug delivery systems. In this study, a drug delivery system consisting of a methacrylate-based polymer and flurbiprofen was studied, and its release profile in a controlled phosphate-buffered saline solution was characterized. The polymer, which was 3D printed and processed in supercritical carbon dioxide under different temperature and pressure settings, showed sustained drug release over a prolonged period. A computer algorithm was used to determine the drug release time duration before reaching steady state and the maximum drug release at steady state. Several empirical models were applied to fit the release kinetic data to gain information about the drug release mechanism. The diffusion coefficients for each system were also estimated using Fick’s law. Based on the results, the influence of supercritical carbon dioxide processing conditions on the diffusion behavior is interpreted, providing insights into the effective and tunable design of drug delivery systems for targeted treatment specifications.https://www.mdpi.com/1999-4923/15/4/1301polymersupercritical carbon dioxideflurbiprofen3D printingcontrolled releasemodeling |
| spellingShingle | Truc T. Ngo Jae D. Kim Controlled Release of Flurbiprofen from 3D-Printed and Supercritical Carbon Dioxide Processed Methacrylate-Based Polymer Pharmaceutics polymer supercritical carbon dioxide flurbiprofen 3D printing controlled release modeling |
| title | Controlled Release of Flurbiprofen from 3D-Printed and Supercritical Carbon Dioxide Processed Methacrylate-Based Polymer |
| title_full | Controlled Release of Flurbiprofen from 3D-Printed and Supercritical Carbon Dioxide Processed Methacrylate-Based Polymer |
| title_fullStr | Controlled Release of Flurbiprofen from 3D-Printed and Supercritical Carbon Dioxide Processed Methacrylate-Based Polymer |
| title_full_unstemmed | Controlled Release of Flurbiprofen from 3D-Printed and Supercritical Carbon Dioxide Processed Methacrylate-Based Polymer |
| title_short | Controlled Release of Flurbiprofen from 3D-Printed and Supercritical Carbon Dioxide Processed Methacrylate-Based Polymer |
| title_sort | controlled release of flurbiprofen from 3d printed and supercritical carbon dioxide processed methacrylate based polymer |
| topic | polymer supercritical carbon dioxide flurbiprofen 3D printing controlled release modeling |
| url | https://www.mdpi.com/1999-4923/15/4/1301 |
| work_keys_str_mv | AT tructngo controlledreleaseofflurbiprofenfrom3dprintedandsupercriticalcarbondioxideprocessedmethacrylatebasedpolymer AT jaedkim controlledreleaseofflurbiprofenfrom3dprintedandsupercriticalcarbondioxideprocessedmethacrylatebasedpolymer |