The Microbiome Modulates the Immune System to Influence Cancer Therapy
The gut microbiota composition can affect the tumor microenvironment and its interaction with the immune system, thereby having implications for treatment predictions. This article reviews the studies available to better understand how the gut microbiome helps the immune system fight cancer. To desc...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2024-02-01
|
| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/16/4/779 |
| _version_ | 1797298630127779840 |
|---|---|
| author | Ruchi Roy Sunil Kumar Singh |
| author_facet | Ruchi Roy Sunil Kumar Singh |
| author_sort | Ruchi Roy |
| collection | DOAJ |
| description | The gut microbiota composition can affect the tumor microenvironment and its interaction with the immune system, thereby having implications for treatment predictions. This article reviews the studies available to better understand how the gut microbiome helps the immune system fight cancer. To describe this fact, different mechanisms and approaches utilizing probiotics to improve advancements in cancer treatment will be discussed. Moreover, not only calorie intake but also the variety and quality of diet can influence cancer patients’ immunotherapy treatment because dietary patterns can impair immunological activities either by stimulating or suppressing innate and adaptive immunity. Therefore, it is interesting and critical to understand gut microbiome composition as a biomarker to predict cancer immunotherapy outcomes and responses. Here, more emphasis will be given to the recent development in immunotherapies utilizing microbiota to improve cancer therapies, which is beneficial for cancer patients. |
| first_indexed | 2024-03-07T22:38:49Z |
| format | Article |
| id | doaj.art-94d35f4bf18443ca8af6f849f34b0bec |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-07T22:38:49Z |
| publishDate | 2024-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-94d35f4bf18443ca8af6f849f34b0bec2024-02-23T15:11:12ZengMDPI AGCancers2072-66942024-02-0116477910.3390/cancers16040779The Microbiome Modulates the Immune System to Influence Cancer TherapyRuchi Roy0Sunil Kumar Singh1UICentre for Drug Discovery, The University of Illinois, Chicago, IL 60612, USADepartment of Surgery, Division of Surgical Oncology, The University of Illinois at Chicago, Chicago, IL 60612, USAThe gut microbiota composition can affect the tumor microenvironment and its interaction with the immune system, thereby having implications for treatment predictions. This article reviews the studies available to better understand how the gut microbiome helps the immune system fight cancer. To describe this fact, different mechanisms and approaches utilizing probiotics to improve advancements in cancer treatment will be discussed. Moreover, not only calorie intake but also the variety and quality of diet can influence cancer patients’ immunotherapy treatment because dietary patterns can impair immunological activities either by stimulating or suppressing innate and adaptive immunity. Therefore, it is interesting and critical to understand gut microbiome composition as a biomarker to predict cancer immunotherapy outcomes and responses. Here, more emphasis will be given to the recent development in immunotherapies utilizing microbiota to improve cancer therapies, which is beneficial for cancer patients.https://www.mdpi.com/2072-6694/16/4/779probioticsmicrobiotacancer immune therapy |
| spellingShingle | Ruchi Roy Sunil Kumar Singh The Microbiome Modulates the Immune System to Influence Cancer Therapy Cancers probiotics microbiota cancer immune therapy |
| title | The Microbiome Modulates the Immune System to Influence Cancer Therapy |
| title_full | The Microbiome Modulates the Immune System to Influence Cancer Therapy |
| title_fullStr | The Microbiome Modulates the Immune System to Influence Cancer Therapy |
| title_full_unstemmed | The Microbiome Modulates the Immune System to Influence Cancer Therapy |
| title_short | The Microbiome Modulates the Immune System to Influence Cancer Therapy |
| title_sort | microbiome modulates the immune system to influence cancer therapy |
| topic | probiotics microbiota cancer immune therapy |
| url | https://www.mdpi.com/2072-6694/16/4/779 |
| work_keys_str_mv | AT ruchiroy themicrobiomemodulatestheimmunesystemtoinfluencecancertherapy AT sunilkumarsingh themicrobiomemodulatestheimmunesystemtoinfluencecancertherapy AT ruchiroy microbiomemodulatestheimmunesystemtoinfluencecancertherapy AT sunilkumarsingh microbiomemodulatestheimmunesystemtoinfluencecancertherapy |