Early inner plexiform layer thinning and retinal nerve fiber layer thickening in excitotoxic retinal injury using deep learning-assisted optical coherence tomography

Early inner plexiform layer thinning and retinal nerve fiber layer thickening in excitotoxic retinal injury using deep learning-assisted optical coherence tomography

Abstract Excitotoxicity from the impairment of glutamate uptake constitutes an important mechanism in neurodegenerative diseases such as Alzheimer’s, multiple sclerosis, and Parkinson's disease. Within the eye, excitotoxicity is thought to play a critical role in retinal ganglion cell death in...

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Bibliographic Details
Main Authors: Da Ma, Wenyu Deng, Zain Khera, Thajunnisa A. Sajitha, Xinlei Wang, Gadi Wollstein, Joel S. Schuman, Sieun Lee, Haolun Shi, Myeong Jin Ju, Joanne Matsubara, Mirza Faisal Beg, Marinko Sarunic, Rebecca M. Sappington, Kevin C. Chan
Format: Article
Language:English
Published: BMC 2024-02-01
Series:Acta Neuropathologica Communications
Subjects:
Deep learning
Excitotoxicity
N-methyl-d-aspartate
Optical coherence tomography
Retinal thickness
Transfer learning
Online Access:https://doi.org/10.1186/s40478-024-01732-z

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