The association between estradiol levels and cognitive function in postmenopausal women
Background: Levels of estradiol decreases as women arrive the menopausal transition and enter to a low, steady level during the early postmenopause. In addition, memory dysfunction are highly prevalent during this period. Objective: Our study was designed to determine whether endogenous levels of es...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Shahid Sadoughi University of Medical Sciences
2018-07-01
|
| Series: | International Journal of Reproductive BioMedicine |
| Subjects: | |
| Online Access: | http://journals.ssu.ac.ir/ijrmnew/browse.php?a_code=A-10-1-593&slc_lang=en&sid=1 |
| _version_ | 1828492778258038784 |
|---|---|
| author | Soheila Gholizadeh Shahideh Jahanian Sadatmahalleh Saeideh Ziaei |
| author_facet | Soheila Gholizadeh Shahideh Jahanian Sadatmahalleh Saeideh Ziaei |
| author_sort | Soheila Gholizadeh |
| collection | DOAJ |
| description | Background: Levels of estradiol decreases as women arrive the menopausal transition and enter to a low, steady level during the early postmenopause. In addition, memory dysfunction are highly prevalent during this period. Objective: Our study was designed to determine whether endogenous levels of estradiol are related to cognitive function in postmenopausal. Materials and Methods: The cross-sectional study was conducted between November 2015 to February 2016 on 209 healthy postmenopausal women. The women filled out the Montreal Cognitive Assessment (MoCA) scale. Then, estradiol level was tested for association with cognitive function adjusted for factors supposed to confound this association. Results: The prevalence of cognitive dysfunction; MoCA points ≤26 in our participants was 62.7%, and mean±SD of estradiol level was 14.92±10.24pg/ml in participants with cognitive dysfunction in comparison with 21.67±14.92pg/ml in those with normal cognitive function (p<0.001). There were significant association between MoCA points with estradiol level (p<0.001) and educational status (p<0.001). Conclusion: Estradiol replacement therapy in postmenopausal women with low endogenous estradiol levels and decreased cognitive function might be necessary. |
| first_indexed | 2024-12-11T11:27:41Z |
| format | Article |
| id | doaj.art-94d99b5877bd4f859abad9b31bedcda9 |
| institution | Directory Open Access Journal |
| issn | 2476-4108 2476-3772 |
| language | English |
| last_indexed | 2024-12-11T11:27:41Z |
| publishDate | 2018-07-01 |
| publisher | Shahid Sadoughi University of Medical Sciences |
| record_format | Article |
| series | International Journal of Reproductive BioMedicine |
| spelling | doaj.art-94d99b5877bd4f859abad9b31bedcda92022-12-22T01:08:59ZengShahid Sadoughi University of Medical SciencesInternational Journal of Reproductive BioMedicine2476-41082476-37722018-07-01167455458The association between estradiol levels and cognitive function in postmenopausal womenSoheila Gholizadeh0Shahideh Jahanian Sadatmahalleh1Saeideh Ziaei2 Department of Midwifery and Reproductive Health, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran. Department of Midwifery and Reproductive Health, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran Department of Midwifery and Reproductive Health, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran Background: Levels of estradiol decreases as women arrive the menopausal transition and enter to a low, steady level during the early postmenopause. In addition, memory dysfunction are highly prevalent during this period. Objective: Our study was designed to determine whether endogenous levels of estradiol are related to cognitive function in postmenopausal. Materials and Methods: The cross-sectional study was conducted between November 2015 to February 2016 on 209 healthy postmenopausal women. The women filled out the Montreal Cognitive Assessment (MoCA) scale. Then, estradiol level was tested for association with cognitive function adjusted for factors supposed to confound this association. Results: The prevalence of cognitive dysfunction; MoCA points ≤26 in our participants was 62.7%, and mean±SD of estradiol level was 14.92±10.24pg/ml in participants with cognitive dysfunction in comparison with 21.67±14.92pg/ml in those with normal cognitive function (p<0.001). There were significant association between MoCA points with estradiol level (p<0.001) and educational status (p<0.001). Conclusion: Estradiol replacement therapy in postmenopausal women with low endogenous estradiol levels and decreased cognitive function might be necessary.http://journals.ssu.ac.ir/ijrmnew/browse.php?a_code=A-10-1-593&slc_lang=en&sid=1Cognitive function Estradiol level Menopause |
| spellingShingle | Soheila Gholizadeh Shahideh Jahanian Sadatmahalleh Saeideh Ziaei The association between estradiol levels and cognitive function in postmenopausal women International Journal of Reproductive BioMedicine Cognitive function Estradiol level Menopause |
| title | The association between estradiol levels and cognitive function in postmenopausal women |
| title_full | The association between estradiol levels and cognitive function in postmenopausal women |
| title_fullStr | The association between estradiol levels and cognitive function in postmenopausal women |
| title_full_unstemmed | The association between estradiol levels and cognitive function in postmenopausal women |
| title_short | The association between estradiol levels and cognitive function in postmenopausal women |
| title_sort | association between estradiol levels and cognitive function in postmenopausal women |
| topic | Cognitive function Estradiol level Menopause |
| url | http://journals.ssu.ac.ir/ijrmnew/browse.php?a_code=A-10-1-593&slc_lang=en&sid=1 |
| work_keys_str_mv | AT soheilagholizadeh theassociationbetweenestradiollevelsandcognitivefunctioninpostmenopausalwomen AT shahidehjahaniansadatmahalleh theassociationbetweenestradiollevelsandcognitivefunctioninpostmenopausalwomen AT saeidehziaei theassociationbetweenestradiollevelsandcognitivefunctioninpostmenopausalwomen AT soheilagholizadeh associationbetweenestradiollevelsandcognitivefunctioninpostmenopausalwomen AT shahidehjahaniansadatmahalleh associationbetweenestradiollevelsandcognitivefunctioninpostmenopausalwomen AT saeidehziaei associationbetweenestradiollevelsandcognitivefunctioninpostmenopausalwomen |