Intensity-Modulated Radiotherapy in the Treatment of Pancreatic Adenocarcinoma – A Review
Pancreatic cancer remains one of the leading causes of cancer deaths. Despite improvements in imaging, surgical techniques, chemotherapy agents, and radiation techniques, the prognosis for patients with pancreatic adenocarcinoma remains poor. Traditionally, radiotherapy (RT) has been utilized as neo...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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European Medical Journal
2013-10-01
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| Series: | European Medical Journal Oncology |
| Subjects: | |
| Online Access: | http://emjreviews.com/wp-content/uploads/INTENSITY-MODULATED-RADIOTHERAPY-IN-THE-TREATMENT-OF-PANCREATIC-ADENOCARCINOMA-A-REVIEW-1.pdf |
| _version_ | 1818344993871364096 |
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| author | Luciana Caravatta Gabriella Macchia Francesco Deodato Marco Felicetti Francesco Cellini Antonella Ciabattoni Milly Buwenge Vincenzo Picardi Savino Cilla Andrea Scapati Vincenzo Valentini Alessio G. Morganti |
| author_facet | Luciana Caravatta Gabriella Macchia Francesco Deodato Marco Felicetti Francesco Cellini Antonella Ciabattoni Milly Buwenge Vincenzo Picardi Savino Cilla Andrea Scapati Vincenzo Valentini Alessio G. Morganti |
| author_sort | Luciana Caravatta |
| collection | DOAJ |
| description | Pancreatic cancer remains one of the leading causes of cancer deaths. Despite improvements in imaging, surgical techniques, chemotherapy agents, and radiation techniques, the prognosis for patients with pancreatic adenocarcinoma remains poor. Traditionally, radiotherapy (RT) has been utilized as neoadjuvant, adjuvant, or definitive treatment, and represents an important therapeutic option in pancreatic adenocarcinoma. Intensity-modulated radiation therapy (IMRT), a more recent RT technique, has the potential to deliver an adequate dose to the tumour volume with a minimal dose to the surrounding critical structures such as duodenum, small intestine, liver, kidneys, and spinal cord. This article provides a review about the role of IMRT in the treatment of pancreatic cancer, concerning clinical outcomes such as toxicity, local control, and overall survival. |
| first_indexed | 2024-12-13T16:55:19Z |
| format | Article |
| id | doaj.art-94da8f45f99749c2808b96bd31653af3 |
| institution | Directory Open Access Journal |
| issn | 2054-619X |
| language | English |
| last_indexed | 2024-12-13T16:55:19Z |
| publishDate | 2013-10-01 |
| publisher | European Medical Journal |
| record_format | Article |
| series | European Medical Journal Oncology |
| spelling | doaj.art-94da8f45f99749c2808b96bd31653af32022-12-21T23:37:56ZengEuropean Medical JournalEuropean Medical Journal Oncology2054-619X2013-10-01119097Intensity-Modulated Radiotherapy in the Treatment of Pancreatic Adenocarcinoma – A ReviewLuciana Caravatta0Gabriella Macchia1Francesco Deodato2Marco Felicetti3Francesco Cellini4Antonella Ciabattoni5Milly Buwenge6Vincenzo Picardi7Savino Cilla8Andrea Scapati9Vincenzo Valentini10Alessio G. Morganti11Radiation Oncology Department, Fondazione di Ricerca e Cura “Giovanni Paolo II,” Università Cattolica del S. Cuore, Campobasso, Italy. Radiation Oncology Department, “San Francesco” Hospital, Nuoro, ItalyRadiation Oncology Department, Fondazione di Ricerca e Cura “Giovanni Paolo II,” Università Cattolica del S. Cuore, Campobasso, ItalyRadiation Oncology Department, Fondazione di Ricerca e Cura “Giovanni Paolo II,” Università Cattolica del S. Cuore, Campobasso, ItalyRadiation Oncology Department, Fondazione di Ricerca e Cura “Giovanni Paolo II,” Università Cattolica del S. Cuore, Campobasso, ItalyRadiotherapy Department, Università Campus Biomedico, Rome, ItalyRadiotherapy Departement, S. Filippo Neri Hospital, Rome, ItalyRadiotherapy Department, Mulago Hospital, Kampala, UgandaRadiation Oncology Department, Fondazione di Ricerca e Cura “Giovanni Paolo II,” Università Cattolica del S. Cuore, Campobasso, ItalyMedical Physics Unit, Fondazione di Ricerca e Cura “Giovanni Paolo II,” Università Cattolica del S. Cuore, Campobasso, ItalyRadiation Oncology Department, “San Francesco” Hospital, Nuoro, ItalyRadiotherapy Department, Università Cattolica del S. Cuore, Roma, ItalyRadiation Oncology Department, Fondazione di Ricerca e Cura “Giovanni Paolo II,” Università Cattolica del S. Cuore, Campobasso, Italy. Radiotherapy Department, Università Cattolica del S. Cuore, Roma, ItalyPancreatic cancer remains one of the leading causes of cancer deaths. Despite improvements in imaging, surgical techniques, chemotherapy agents, and radiation techniques, the prognosis for patients with pancreatic adenocarcinoma remains poor. Traditionally, radiotherapy (RT) has been utilized as neoadjuvant, adjuvant, or definitive treatment, and represents an important therapeutic option in pancreatic adenocarcinoma. Intensity-modulated radiation therapy (IMRT), a more recent RT technique, has the potential to deliver an adequate dose to the tumour volume with a minimal dose to the surrounding critical structures such as duodenum, small intestine, liver, kidneys, and spinal cord. This article provides a review about the role of IMRT in the treatment of pancreatic cancer, concerning clinical outcomes such as toxicity, local control, and overall survival.http://emjreviews.com/wp-content/uploads/INTENSITY-MODULATED-RADIOTHERAPY-IN-THE-TREATMENT-OF-PANCREATIC-ADENOCARCINOMA-A-REVIEW-1.pdfIntensity-Modulated RadiotherapyOutcomePancreatic CancerToxicity |
| spellingShingle | Luciana Caravatta Gabriella Macchia Francesco Deodato Marco Felicetti Francesco Cellini Antonella Ciabattoni Milly Buwenge Vincenzo Picardi Savino Cilla Andrea Scapati Vincenzo Valentini Alessio G. Morganti Intensity-Modulated Radiotherapy in the Treatment of Pancreatic Adenocarcinoma – A Review European Medical Journal Oncology Intensity-Modulated Radiotherapy Outcome Pancreatic Cancer Toxicity |
| title | Intensity-Modulated Radiotherapy in the Treatment of Pancreatic Adenocarcinoma – A Review |
| title_full | Intensity-Modulated Radiotherapy in the Treatment of Pancreatic Adenocarcinoma – A Review |
| title_fullStr | Intensity-Modulated Radiotherapy in the Treatment of Pancreatic Adenocarcinoma – A Review |
| title_full_unstemmed | Intensity-Modulated Radiotherapy in the Treatment of Pancreatic Adenocarcinoma – A Review |
| title_short | Intensity-Modulated Radiotherapy in the Treatment of Pancreatic Adenocarcinoma – A Review |
| title_sort | intensity modulated radiotherapy in the treatment of pancreatic adenocarcinoma a review |
| topic | Intensity-Modulated Radiotherapy Outcome Pancreatic Cancer Toxicity |
| url | http://emjreviews.com/wp-content/uploads/INTENSITY-MODULATED-RADIOTHERAPY-IN-THE-TREATMENT-OF-PANCREATIC-ADENOCARCINOMA-A-REVIEW-1.pdf |
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