Recent advances in primary cilia in bone metabolism
Primary cilia are microtubule-based organelles that are widespread on the cell surface and play a key role in tissue development and homeostasis by sensing and transducing various signaling pathways. The process of intraflagellar transport (IFT), which is propelled by kinesin and dynein motors, play...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-10-01
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| Series: | Frontiers in Endocrinology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2023.1259650/full |
| _version_ | 1797662875598192640 |
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| author | Fenfen Lian Hui Li Yuwei Ma Rui Zhou Wei Wu |
| author_facet | Fenfen Lian Hui Li Yuwei Ma Rui Zhou Wei Wu |
| author_sort | Fenfen Lian |
| collection | DOAJ |
| description | Primary cilia are microtubule-based organelles that are widespread on the cell surface and play a key role in tissue development and homeostasis by sensing and transducing various signaling pathways. The process of intraflagellar transport (IFT), which is propelled by kinesin and dynein motors, plays a crucial role in the formation and functionality of cilia. Abnormalities in the cilia or ciliary transport system often cause a range of clinical conditions collectively known as ciliopathies, which include polydactyly, short ribs, scoliosis, thoracic stenosis and many abnormalities in the bones and cartilage. In this review, we summarize recent findings on the role of primary cilia and ciliary transport systems in bone development, we describe the role of cilia in bone formation, cartilage development and bone resorption, and we summarize advances in the study of primary cilia in fracture healing. In addition, the recent discovery of crosstalk between integrins and primary cilia provides new insights into how primary cilia affect bone. |
| first_indexed | 2024-03-11T19:06:26Z |
| format | Article |
| id | doaj.art-94dc915e4b4e416fb371fb2e295c52bb |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-03-11T19:06:26Z |
| publishDate | 2023-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-94dc915e4b4e416fb371fb2e295c52bb2023-10-10T07:20:54ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922023-10-011410.3389/fendo.2023.12596501259650Recent advances in primary cilia in bone metabolismFenfen Lian0Hui Li1Yuwei Ma2Rui Zhou3Wei Wu4School of Exercise and Health, Shanghai University of Sport, Shanghai, ChinaSchool of Exercise and Health, Shanghai University of Sport, Shanghai, ChinaSchool of Exercise and Health, Shanghai University of Sport, Shanghai, ChinaSchool of Exercise and Health, Shanghai University of Sport, Shanghai, ChinaSchool of Athletic Performance, Shanghai University of Sport, Shanghai, ChinaPrimary cilia are microtubule-based organelles that are widespread on the cell surface and play a key role in tissue development and homeostasis by sensing and transducing various signaling pathways. The process of intraflagellar transport (IFT), which is propelled by kinesin and dynein motors, plays a crucial role in the formation and functionality of cilia. Abnormalities in the cilia or ciliary transport system often cause a range of clinical conditions collectively known as ciliopathies, which include polydactyly, short ribs, scoliosis, thoracic stenosis and many abnormalities in the bones and cartilage. In this review, we summarize recent findings on the role of primary cilia and ciliary transport systems in bone development, we describe the role of cilia in bone formation, cartilage development and bone resorption, and we summarize advances in the study of primary cilia in fracture healing. In addition, the recent discovery of crosstalk between integrins and primary cilia provides new insights into how primary cilia affect bone.https://www.frontiersin.org/articles/10.3389/fendo.2023.1259650/fullprimary ciliabone formationchondrogenesisbone resorptionfracture healingintegrins |
| spellingShingle | Fenfen Lian Hui Li Yuwei Ma Rui Zhou Wei Wu Recent advances in primary cilia in bone metabolism Frontiers in Endocrinology primary cilia bone formation chondrogenesis bone resorption fracture healing integrins |
| title | Recent advances in primary cilia in bone metabolism |
| title_full | Recent advances in primary cilia in bone metabolism |
| title_fullStr | Recent advances in primary cilia in bone metabolism |
| title_full_unstemmed | Recent advances in primary cilia in bone metabolism |
| title_short | Recent advances in primary cilia in bone metabolism |
| title_sort | recent advances in primary cilia in bone metabolism |
| topic | primary cilia bone formation chondrogenesis bone resorption fracture healing integrins |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2023.1259650/full |
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