The molecular epidemiology of <it>Stenotrophomonas maltophilia </it>bacteraemia in a tertiary referral hospital in the United Arab Emirates 2000–2004
<p>Abstract</p> <p>Background</p> <p><it>Stenotrophomonas maltophilia </it>is recognised as an important cause of nosocomial infection, especially in immunocompromised patients, resulting in significant morbidity and mortality. The treatment of <it>S....
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2006-12-01
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| Series: | Annals of Clinical Microbiology and Antimicrobials |
| Online Access: | http://www.ann-clinmicrob.com/content/5/1/32 |
| _version_ | 1811252451666296832 |
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| author | Pàl Tibor Sonnevend Agnes Jumaa Pauline A El Hag Mohammed Amith Ray Trad Omar |
| author_facet | Pàl Tibor Sonnevend Agnes Jumaa Pauline A El Hag Mohammed Amith Ray Trad Omar |
| author_sort | Pàl Tibor |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p><it>Stenotrophomonas maltophilia </it>is recognised as an important cause of nosocomial infection, especially in immunocompromised patients, resulting in significant morbidity and mortality. The treatment of <it>S. maltophilia </it>infection presents a therapeutic challenge. The precise modes of transmission of <it>S. maltophilia </it>in the hospital environment are not known and such knowledge is essential to target interventions to prevent spread. There are few published data on the patterns of nosocomial infection in the United Arab Emirates (UAE). A recent study showed that <it>S. maltophilia </it>is an established cause of bloodstream infection in Tawam Hospital in the UAE. Little is known about its epidemiology in the hospital.</p> <p>Methods</p> <p>We describe the clinical characteristics of 25 episodes of <it>S. maltophilia </it>bacteraemia which occurred from 2000–2004. The strains were characterised using pulsed field gel electrophoresis (PFGE).</p> <p>Results</p> <p>All episodes were hospital-acquired and malignancy and central venous catheters were predisposing factors. Catheter-associated infection comprised 88% infection. Catheter removal was important for the successful management of catheter-associated infection. The results of PFGE suggested that there were as many strains as patients. <it>S. maltophilia </it>strains isolated from the same patient had indistinguishable PFGE profiles.</p> <p>Conclusion</p> <p>PFGE is a valid and reproducible typing method for <it>S. maltophilia</it>. The precise sources and modes of spread of <it>S. maltophilia </it>in the hospital are still not known. Knowledge that person to person transmission was not a major mode of transmission enabled infection control interventions for <it>S. maltophilia </it>to be targeted more effectively.</p> |
| first_indexed | 2024-04-12T16:34:48Z |
| format | Article |
| id | doaj.art-94dd2633c92445519042fba2922ce833 |
| institution | Directory Open Access Journal |
| issn | 1476-0711 |
| language | English |
| last_indexed | 2024-04-12T16:34:48Z |
| publishDate | 2006-12-01 |
| publisher | BMC |
| record_format | Article |
| series | Annals of Clinical Microbiology and Antimicrobials |
| spelling | doaj.art-94dd2633c92445519042fba2922ce8332022-12-22T03:25:01ZengBMCAnnals of Clinical Microbiology and Antimicrobials1476-07112006-12-01513210.1186/1476-0711-5-32The molecular epidemiology of <it>Stenotrophomonas maltophilia </it>bacteraemia in a tertiary referral hospital in the United Arab Emirates 2000–2004Pàl TiborSonnevend AgnesJumaa Pauline AEl Hag MohammedAmith RayTrad Omar<p>Abstract</p> <p>Background</p> <p><it>Stenotrophomonas maltophilia </it>is recognised as an important cause of nosocomial infection, especially in immunocompromised patients, resulting in significant morbidity and mortality. The treatment of <it>S. maltophilia </it>infection presents a therapeutic challenge. The precise modes of transmission of <it>S. maltophilia </it>in the hospital environment are not known and such knowledge is essential to target interventions to prevent spread. There are few published data on the patterns of nosocomial infection in the United Arab Emirates (UAE). A recent study showed that <it>S. maltophilia </it>is an established cause of bloodstream infection in Tawam Hospital in the UAE. Little is known about its epidemiology in the hospital.</p> <p>Methods</p> <p>We describe the clinical characteristics of 25 episodes of <it>S. maltophilia </it>bacteraemia which occurred from 2000–2004. The strains were characterised using pulsed field gel electrophoresis (PFGE).</p> <p>Results</p> <p>All episodes were hospital-acquired and malignancy and central venous catheters were predisposing factors. Catheter-associated infection comprised 88% infection. Catheter removal was important for the successful management of catheter-associated infection. The results of PFGE suggested that there were as many strains as patients. <it>S. maltophilia </it>strains isolated from the same patient had indistinguishable PFGE profiles.</p> <p>Conclusion</p> <p>PFGE is a valid and reproducible typing method for <it>S. maltophilia</it>. The precise sources and modes of spread of <it>S. maltophilia </it>in the hospital are still not known. Knowledge that person to person transmission was not a major mode of transmission enabled infection control interventions for <it>S. maltophilia </it>to be targeted more effectively.</p>http://www.ann-clinmicrob.com/content/5/1/32 |
| spellingShingle | Pàl Tibor Sonnevend Agnes Jumaa Pauline A El Hag Mohammed Amith Ray Trad Omar The molecular epidemiology of <it>Stenotrophomonas maltophilia </it>bacteraemia in a tertiary referral hospital in the United Arab Emirates 2000–2004 Annals of Clinical Microbiology and Antimicrobials |
| title | The molecular epidemiology of <it>Stenotrophomonas maltophilia </it>bacteraemia in a tertiary referral hospital in the United Arab Emirates 2000–2004 |
| title_full | The molecular epidemiology of <it>Stenotrophomonas maltophilia </it>bacteraemia in a tertiary referral hospital in the United Arab Emirates 2000–2004 |
| title_fullStr | The molecular epidemiology of <it>Stenotrophomonas maltophilia </it>bacteraemia in a tertiary referral hospital in the United Arab Emirates 2000–2004 |
| title_full_unstemmed | The molecular epidemiology of <it>Stenotrophomonas maltophilia </it>bacteraemia in a tertiary referral hospital in the United Arab Emirates 2000–2004 |
| title_short | The molecular epidemiology of <it>Stenotrophomonas maltophilia </it>bacteraemia in a tertiary referral hospital in the United Arab Emirates 2000–2004 |
| title_sort | molecular epidemiology of it stenotrophomonas maltophilia it bacteraemia in a tertiary referral hospital in the united arab emirates 2000 2004 |
| url | http://www.ann-clinmicrob.com/content/5/1/32 |
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