Drug-drug interactions with antiretroviral therapy among people living with HIV in Asia and other regions: Risk factors and impact on indicators of health-related quality of life
Introduction While studies have extensively examined the clinical and pharmacokinetic correlates of drug-drug interactions (DDIs) with antiretroviral therapy (ART), less is known about DDIs from the perspective of people living with HIV (PLHIV). Among an international sample of PLHIV, we examined ex...
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| Format: | Article |
| Language: | English |
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European Publishing
2022-04-01
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| Series: | Population Medicine |
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| Online Access: | http://www.populationmedicine.eu/Drug-drug-interactions-with-antiretroviral-therapy-among-people-living-with-HIV-in,149454,0,2.html |
| _version_ | 1817980894188666880 |
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| author | Sejun Park Yu-Hsiang Hsiao Fei Yu Keita Kambara Brent Allan Garry Brough Ta-Fen Hwang Nathalie Dang Benjamin Young Rickesh Patel Andres Maldonado Chinyere Okoli |
| author_facet | Sejun Park Yu-Hsiang Hsiao Fei Yu Keita Kambara Brent Allan Garry Brough Ta-Fen Hwang Nathalie Dang Benjamin Young Rickesh Patel Andres Maldonado Chinyere Okoli |
| author_sort | Sejun Park |
| collection | DOAJ |
| description | Introduction
While studies have extensively examined
the clinical and pharmacokinetic correlates of drug-drug
interactions (DDIs) with antiretroviral therapy (ART), less
is known about DDIs from the perspective of people living
with HIV (PLHIV). Among an international sample of PLHIV,
we examined experiences, concerns and challenges regarding
DDIs.
Methods
Data came from an international, web-based survey
that was conducted among adult PLHIV aged ≥18 years who
were receiving ART during 2019 (Positive Perspectives
Wave 2, n=2389). Data were analyzed using descriptive
statistics and with a special focus on the Asian region
comprising participants from China, Taiwan, Japan, and
South Korea (n=230). Multivariable analyses were performed
using pooled data from all 2389 participants. Statistical
significance was at p<0.05.
Results
Overall, 59.1% (136/230) of Asian participants
were concerned about the risk of DDIs, 58.3% (134/230)
were concerned about having to take more medicines
as they grew older, and 25.9% (44/170) of those who
had ever switched ART attributed it to DDIs, higher than
every other geographical region except North America.
Among Asian participants, 86.0% (43/50) of those aged
≥50 years reported having ever been diagnosed with a
non-HIV comorbidity versus 60.0% (108/180) aged <50
years (p=0.001). Within the pooled sample, adults aged
≥50 years were more likely to perceive the need to reduce
DDIs as a current treatment priority, than younger adults
(adjusted prevalence ratio, APR=1.14; 95% CI: 1.02–1.27).
The percentage of the entire population that ever switched
ART because of DDIs ranged from 10.6% (148/1402) among
those receiving treatment for HIV only, to 26.4% (14/53)
among those receiving treatment for ≥7 conditions (including
HIV).
Conclusions
Older adults reported more comorbidities
than younger ones, and the probability of having switched
ART because of DDIs increased with increasing concurrent
treatments. Providing simpler regimens may help reduce
the risk of DDIs. Healthcare providers can improve PLHIV’s
health-related quality of life by delivering person-centered
care. |
| first_indexed | 2024-04-13T22:59:42Z |
| format | Article |
| id | doaj.art-94dd99f27f1c4c0e9bf72a88d9541835 |
| institution | Directory Open Access Journal |
| issn | 2654-1459 |
| language | English |
| last_indexed | 2024-04-13T22:59:42Z |
| publishDate | 2022-04-01 |
| publisher | European Publishing |
| record_format | Article |
| series | Population Medicine |
| spelling | doaj.art-94dd99f27f1c4c0e9bf72a88d95418352022-12-22T02:25:54ZengEuropean PublishingPopulation Medicine2654-14592022-04-014April11510.18332/popmed/149454149454Drug-drug interactions with antiretroviral therapy among people living with HIV in Asia and other regions: Risk factors and impact on indicators of health-related quality of lifeSejun Park0Yu-Hsiang Hsiao1Fei Yu2Keita Kambara3Brent Allan4Garry Brough5Ta-Fen Hwang6Nathalie Dang7Benjamin Young8Rickesh Patel9Andres Maldonado10Chinyere Okoli11Love4One, Seoul, South KoreaPositive Alliance, TaiwanDanlan Beijing Media Limited, Beijing, ChinaJapanese Network of People living with HIV/AIDS, Tokyo, JapanAustralasian Society for HIV, Viral Hepatitis and Sexual Health Medicine, Sydney, AustraliaPositively UK, London, United KingdomViiV Healthcare, SingaporeViiV Healthcare, SingaporeViiV Healthcare, Research Triangle Park, United StatesViiV Healthcare, Brentford Middlesex, United KingdomViiV Healthcare, Wavre, BelgiumViiV Healthcare, Brentford Middlesex, United KingdomIntroduction While studies have extensively examined the clinical and pharmacokinetic correlates of drug-drug interactions (DDIs) with antiretroviral therapy (ART), less is known about DDIs from the perspective of people living with HIV (PLHIV). Among an international sample of PLHIV, we examined experiences, concerns and challenges regarding DDIs. Methods Data came from an international, web-based survey that was conducted among adult PLHIV aged ≥18 years who were receiving ART during 2019 (Positive Perspectives Wave 2, n=2389). Data were analyzed using descriptive statistics and with a special focus on the Asian region comprising participants from China, Taiwan, Japan, and South Korea (n=230). Multivariable analyses were performed using pooled data from all 2389 participants. Statistical significance was at p<0.05. Results Overall, 59.1% (136/230) of Asian participants were concerned about the risk of DDIs, 58.3% (134/230) were concerned about having to take more medicines as they grew older, and 25.9% (44/170) of those who had ever switched ART attributed it to DDIs, higher than every other geographical region except North America. Among Asian participants, 86.0% (43/50) of those aged ≥50 years reported having ever been diagnosed with a non-HIV comorbidity versus 60.0% (108/180) aged <50 years (p=0.001). Within the pooled sample, adults aged ≥50 years were more likely to perceive the need to reduce DDIs as a current treatment priority, than younger adults (adjusted prevalence ratio, APR=1.14; 95% CI: 1.02–1.27). The percentage of the entire population that ever switched ART because of DDIs ranged from 10.6% (148/1402) among those receiving treatment for HIV only, to 26.4% (14/53) among those receiving treatment for ≥7 conditions (including HIV). Conclusions Older adults reported more comorbidities than younger ones, and the probability of having switched ART because of DDIs increased with increasing concurrent treatments. Providing simpler regimens may help reduce the risk of DDIs. Healthcare providers can improve PLHIV’s health-related quality of life by delivering person-centered care.http://www.populationmedicine.eu/Drug-drug-interactions-with-antiretroviral-therapy-among-people-living-with-HIV-in,149454,0,2.htmldrug-drug interactionscomedicationscomorbiditiesantiretroviral therapy |
| spellingShingle | Sejun Park Yu-Hsiang Hsiao Fei Yu Keita Kambara Brent Allan Garry Brough Ta-Fen Hwang Nathalie Dang Benjamin Young Rickesh Patel Andres Maldonado Chinyere Okoli Drug-drug interactions with antiretroviral therapy among people living with HIV in Asia and other regions: Risk factors and impact on indicators of health-related quality of life Population Medicine drug-drug interactions comedications comorbidities antiretroviral therapy |
| title | Drug-drug interactions with antiretroviral therapy among people living with HIV in Asia and other regions:
Risk factors and impact on indicators of health-related quality of life |
| title_full | Drug-drug interactions with antiretroviral therapy among people living with HIV in Asia and other regions:
Risk factors and impact on indicators of health-related quality of life |
| title_fullStr | Drug-drug interactions with antiretroviral therapy among people living with HIV in Asia and other regions:
Risk factors and impact on indicators of health-related quality of life |
| title_full_unstemmed | Drug-drug interactions with antiretroviral therapy among people living with HIV in Asia and other regions:
Risk factors and impact on indicators of health-related quality of life |
| title_short | Drug-drug interactions with antiretroviral therapy among people living with HIV in Asia and other regions:
Risk factors and impact on indicators of health-related quality of life |
| title_sort | drug drug interactions with antiretroviral therapy among people living with hiv in asia and other regions risk factors and impact on indicators of health related quality of life |
| topic | drug-drug interactions comedications comorbidities antiretroviral therapy |
| url | http://www.populationmedicine.eu/Drug-drug-interactions-with-antiretroviral-therapy-among-people-living-with-HIV-in,149454,0,2.html |
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