Design of polymers for siRNA delivery: Recent progress and challenges
Abstract RNA interference with the ability to specifically silence target genes has shown great potential to treat various diseases. The primary challenge for RNA interference is to effectively and selectively deliver genetic materials such as small interfering RNA (siRNA) to targeted tissues and ce...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2021-06-01
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| Series: | View |
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| Online Access: | https://doi.org/10.1002/VIW.20200026 |
| _version_ | 1818441573338185728 |
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| author | Hui Wang Song Zhang Jia Lv Yiyun Cheng |
| author_facet | Hui Wang Song Zhang Jia Lv Yiyun Cheng |
| author_sort | Hui Wang |
| collection | DOAJ |
| description | Abstract RNA interference with the ability to specifically silence target genes has shown great potential to treat various diseases. The primary challenge for RNA interference is to effectively and selectively deliver genetic materials such as small interfering RNA (siRNA) to targeted tissues and cells in vivo. Numerous efforts have been made to overcome the extracellular and intracellular barriers during siRNA delivery. In this review, we focused on most recent advances in the design of functional polymers to achieve efficient siRNA delivery via addressing the various parameters, including siRNA binding, serum stability, specific targeting, tissue penetration, cellular internalization, endosomal escape, and intracellular siRNA release. The beneficial roles of assembled polymer nanostructures and polymer‐based hybrid nanocomposites in siRNA delivery were also reviewed. Finally, the challenges and perspectives in the future development of polymer‐based siRNA delivery systems will be discussed. |
| first_indexed | 2024-12-14T18:30:24Z |
| format | Article |
| id | doaj.art-94e18ce132d74433a7287651436dd0df |
| institution | Directory Open Access Journal |
| issn | 2688-3988 2688-268X |
| language | English |
| last_indexed | 2024-12-14T18:30:24Z |
| publishDate | 2021-06-01 |
| publisher | Wiley |
| record_format | Article |
| series | View |
| spelling | doaj.art-94e18ce132d74433a7287651436dd0df2022-12-21T22:51:49ZengWileyView2688-39882688-268X2021-06-0123n/an/a10.1002/VIW.20200026Design of polymers for siRNA delivery: Recent progress and challengesHui Wang0Song Zhang1Jia Lv2Yiyun Cheng3South China Advanced Institute for Soft Matter Science and Technology School of Molecular Science and Engineering South China University of Technology Guangzhou ChinaSouth China Advanced Institute for Soft Matter Science and Technology School of Molecular Science and Engineering South China University of Technology Guangzhou ChinaSouth China Advanced Institute for Soft Matter Science and Technology School of Molecular Science and Engineering South China University of Technology Guangzhou ChinaSouth China Advanced Institute for Soft Matter Science and Technology School of Molecular Science and Engineering South China University of Technology Guangzhou ChinaAbstract RNA interference with the ability to specifically silence target genes has shown great potential to treat various diseases. The primary challenge for RNA interference is to effectively and selectively deliver genetic materials such as small interfering RNA (siRNA) to targeted tissues and cells in vivo. Numerous efforts have been made to overcome the extracellular and intracellular barriers during siRNA delivery. In this review, we focused on most recent advances in the design of functional polymers to achieve efficient siRNA delivery via addressing the various parameters, including siRNA binding, serum stability, specific targeting, tissue penetration, cellular internalization, endosomal escape, and intracellular siRNA release. The beneficial roles of assembled polymer nanostructures and polymer‐based hybrid nanocomposites in siRNA delivery were also reviewed. Finally, the challenges and perspectives in the future development of polymer‐based siRNA delivery systems will be discussed.https://doi.org/10.1002/VIW.20200026cancer therapygene therapynanoparticlespolymersRNA interferencesiRNA |
| spellingShingle | Hui Wang Song Zhang Jia Lv Yiyun Cheng Design of polymers for siRNA delivery: Recent progress and challenges View cancer therapy gene therapy nanoparticles polymers RNA interference siRNA |
| title | Design of polymers for siRNA delivery: Recent progress and challenges |
| title_full | Design of polymers for siRNA delivery: Recent progress and challenges |
| title_fullStr | Design of polymers for siRNA delivery: Recent progress and challenges |
| title_full_unstemmed | Design of polymers for siRNA delivery: Recent progress and challenges |
| title_short | Design of polymers for siRNA delivery: Recent progress and challenges |
| title_sort | design of polymers for sirna delivery recent progress and challenges |
| topic | cancer therapy gene therapy nanoparticles polymers RNA interference siRNA |
| url | https://doi.org/10.1002/VIW.20200026 |
| work_keys_str_mv | AT huiwang designofpolymersforsirnadeliveryrecentprogressandchallenges AT songzhang designofpolymersforsirnadeliveryrecentprogressandchallenges AT jialv designofpolymersforsirnadeliveryrecentprogressandchallenges AT yiyuncheng designofpolymersforsirnadeliveryrecentprogressandchallenges |