Illumination of Molecular Pathways in Multiple Sclerosis Lesions and the Immune Mechanism of Matrine Treatment in EAE, a Mouse Model of MS

Illumination of Molecular Pathways in Multiple Sclerosis Lesions and the Immune Mechanism of Matrine Treatment in EAE, a Mouse Model of MS

The etiology of multiple sclerosis (MS) is not clear, and the treatment of MS presents a great challenge. This study aimed to investigate the pathogenesis and potential therapeutic targets of MS and to define target genes of matrine, a quinolizidine alkaloid component derived from the root of Sophor...

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Bibliographic Details
Main Authors: Mengmeng Dou, Xueliang Zhou, Lifeng Li, Mingliang Zhang, Wenbin Wang, Mengru Wang, Yilei Jing, Rui Ma, Jie Zhao, Lin Zhu
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Immunology
Subjects:
matrine
multiple sclerosis
bioinformatics
network pharmacology
IL10RA
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.640778/full

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