Illumination of Molecular Pathways in Multiple Sclerosis Lesions and the Immune Mechanism of Matrine Treatment in EAE, a Mouse Model of MS

Illumination of Molecular Pathways in Multiple Sclerosis Lesions and the Immune Mechanism of Matrine Treatment in EAE, a Mouse Model of MS

The etiology of multiple sclerosis (MS) is not clear, and the treatment of MS presents a great challenge. This study aimed to investigate the pathogenesis and potential therapeutic targets of MS and to define target genes of matrine, a quinolizidine alkaloid component derived from the root of Sophor...

Deskribapen osoa

Xehetasun bibliografikoak
Egile Nagusiak:	Mengmeng Dou, Xueliang Zhou, Lifeng Li, Mingliang Zhang, Wenbin Wang, Mengru Wang, Yilei Jing, Rui Ma, Jie Zhao, Lin Zhu
Formatua:	Artikulua
Hizkuntza:	English
Argitaratua:	Frontiers Media S.A. 2021-04-01
Saila:	Frontiers in Immunology
Gaiak:	matrine multiple sclerosis bioinformatics network pharmacology IL10RA
Sarrera elektronikoa:	https://www.frontiersin.org/articles/10.3389/fimmu.2021.640778/full

Antzeko izenburuak

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Argitaratua: (2022-08-01)

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Matrine Is Identified as a Novel Macropinocytosis Inducer by a Network Target Approach
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Argitaratua: (2024-07-01)

Matrine Inhibits CNS Autoimmunity Through an IFN-β-Dependent Mechanism
nork: Yao-Juan Chu, et al.
Argitaratua: (2020-09-01)

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Argitaratua: (2024-04-01)

Matrine Impairs Platelet Function and Thrombosis and Inhibits ROS Production
nork: Sixuan Zhang, et al.
Argitaratua: (2021-07-01)

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nork: Meng Li, et al.
Argitaratua: (2023-09-01)

Matrine alleviates paraquat-induced pulmonary fibrosis in mouse models
nork: LI Mei-qi, DENG Jun, WANG Song-ping
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Matrine, a potential drug for the treatment of rheumatoid arthritis
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Argitaratua: (2024-03-01)

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Argitaratua: (2013-05-01)

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Argitaratua: (2012-08-01)

Matrine induces V-ATPase-dependent cytoplasmic vacuolation and inhibits the function of the lysosome in leukemia cells
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Argitaratua: (2024-12-01)

Matrine Restrains Cell Growth and Metastasis by Up-Regulating LINC00472 in Bladder Carcinoma
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Argitaratua: (2020-02-01)

Improvement of the Thermal Stability and Aqueous Solubility of Three Matrine Salts Assembled by the Similar Structure Salt Formers
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Argitaratua: (2024-01-01)

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Argitaratua: (2017-04-01)

Zein nanoparticles stabilized by hydrophilic small molecule stabilizer matrine deliver curcumin effectively
nork: Hong Liu, et al.
Argitaratua: (2023-01-01)

Matrine Promotes Human Myeloid Leukemia Cells Apoptosis Through Warburg Effect Mediated by Hexokinase 2
nork: Guibin Lin, et al.
Argitaratua: (2019-09-01)

Matrine promotes mitochondrial biosynthesis and reduces oxidative stress in experimental optic neuritis
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Argitaratua: (2022-09-01)

Matrine: A Promising Natural Product With Various Pharmacological Activities
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Argitaratua: (2020-05-01)

Matrine relieved DHAV-1-induced hepatocyte excessive interferon and pyroptosis by activating mitophagy
nork: Weiran Wang, et al.
Argitaratua: (2025-01-01)

Matrin3: Disorder and ALS Pathogenesis
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Argitaratua: (2022-01-01)

Design, Synthesis and Various Bioactivity of Acylhydrazone-Containing Matrine Analogues
nork: Wanjun Ni, et al.
Argitaratua: (2023-05-01)

RETRACTED: Matrine Protects Cardiomyocytes Against Hyperglycemic Stress by Promoting Mitofusin 2-Induced Mitochondrial Fusion
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Argitaratua: (2021-02-01)

Synthesis of Halopyrazole Matrine Derivatives and Their Insecticidal and Fungicidal Activities
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Argitaratua: (2022-08-01)

Matrine Enhances the Pathogenicity of Beauveria brongniartii Against Spodoptera litura (Lepidoptera: Noctuidae)
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Argitaratua: (2019-08-01)

Self-Assembly of Rhein and Matrine Nanoparticles for Enhanced Wound Healing
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Argitaratua: (2024-07-01)

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Argitaratua: (2023-04-01)

The Effects of Matrine in Combination with Docetaxel on Castration-Resistant (Androgen-Independent) Prostate Cancer
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Argitaratua: (2019-12-01)

14-Thienyl Methylene Matrine (YYJ18), the Derivative from Matrine, Induces Apoptosis of Human Nasopharyngeal Carcinoma Cells by Targeting MAPK and PI3K/Akt Pathways in Vitro
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Argitaratua: (2014-05-01)

Autophagy inhibition enhances Matrine derivative MASM induced apoptosis in cancer cells via a mechanism involving reactive oxygen species-mediated PI3K/Akt/mTOR and Erk/p38 signaling
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Argitaratua: (2019-10-01)

Hepatoprotective effect of Matrine salvianolic acid B salt on Carbon Tetrachloride-Induced Hepatic Fibrosis
nork: Gao Hong-Ying, et al.
Argitaratua: (2012-05-01)

The combined usage of Matrine and Osthole inhibited endoplasmic reticulum apoptosis induced by PCV2
nork: Yinlan Xu, et al.
Argitaratua: (2020-10-01)

Matrine and icariin can inhibit bovine viral diarrhoea virus replication by promoting type I interferon response in vitro
nork: Cai Dongjie, et al.
Argitaratua: (2024-03-01)

Formulation of Matrine Oil-Based Suspension Concentrate for Improving the Wetting of Droplets and Spraying Performance
nork: Meng Li, et al.
Argitaratua: (2023-07-01)

Matrine, a potential c-Myc inhibitor, suppresses ribosome biogenesis and nucleotide metabolism in myeloid leukemia
nork: Wang-Jing Zhong, et al.
Argitaratua: (2022-10-01)

Effect of Matrine on growth performance, gut health, and gut microbiota in chickens infected with avian pathogenic Escherichia coli
nork: Ningning Mao, et al.
Argitaratua: (2025-01-01)