Illumination of Molecular Pathways in Multiple Sclerosis Lesions and the Immune Mechanism of Matrine Treatment in EAE, a Mouse Model of MS

Illumination of Molecular Pathways in Multiple Sclerosis Lesions and the Immune Mechanism of Matrine Treatment in EAE, a Mouse Model of MS

The etiology of multiple sclerosis (MS) is not clear, and the treatment of MS presents a great challenge. This study aimed to investigate the pathogenesis and potential therapeutic targets of MS and to define target genes of matrine, a quinolizidine alkaloid component derived from the root of Sophor...

Bibliografski detalji
Glavni autori:	Mengmeng Dou, Xueliang Zhou, Lifeng Li, Mingliang Zhang, Wenbin Wang, Mengru Wang, Yilei Jing, Rui Ma, Jie Zhao, Lin Zhu
Format:	Članak
Jezik:	English
Izdano:	Frontiers Media S.A. 2021-04-01
Serija:	Frontiers in Immunology
Teme:	matrine multiple sclerosis bioinformatics network pharmacology IL10RA
Online pristup:	https://www.frontiersin.org/articles/10.3389/fimmu.2021.640778/full

Slični predmeti

Research progress on the pharmacological effects of matrine
od: Yanan Sun, i dr.
Izdano: (2022-08-01)

A Systematic Review of the Pharmacology, Toxicology and Pharmacokinetics of Matrine
od: Longtai You, i dr.
Izdano: (2020-09-01)

Research Advances on Matrine
od: Xiao-Ying Sun, i dr.
Izdano: (2022-04-01)

Research Progress of Natural Matrine Compounds and Synthetic Matrine Derivatives
od: Jinlei Li, i dr.
Izdano: (2023-07-01)

Matrine Is Identified as a Novel Macropinocytosis Inducer by a Network Target Approach
od: Bo Zhang, i dr.
Izdano: (2018-01-01)

Matrine Exerts Pharmacological Effects Through Multiple Signaling Pathways: A Comprehensive Review
od: Lin Y, i dr.
Izdano: (2022-03-01)

The potential therapeutic value of the natural plant compounds matrine and oxymatrine in cardiovascular diseases
od: Shanjiang Chen, i dr.
Izdano: (2024-07-01)

Matrine Inhibits CNS Autoimmunity Through an IFN-β-Dependent Mechanism
od: Yao-Juan Chu, i dr.
Izdano: (2020-09-01)

Determination the residues of matrine and oxymatrine in Liupao tea by UPLC-MS/MS with isotope internal standard method
od: SHI Jine, i dr.
Izdano: (2024-04-01)

Matrine Impairs Platelet Function and Thrombosis and Inhibits ROS Production
od: Sixuan Zhang, i dr.
Izdano: (2021-07-01)

Formulation and Characterization of Matrine Oil Dispersion to Improve Droplet Wetting and Deposition
od: Meng Li, i dr.
Izdano: (2023-09-01)

Matrine alleviates paraquat-induced pulmonary fibrosis in mouse models
od: LI Mei-qi, DENG Jun, WANG Song-ping
Izdano: (2022-09-01)

Matrine, a potential drug for the treatment of rheumatoid arthritis
od: Yaping Peng, i dr.
Izdano: (2024-03-01)

Synthesis, Characterization and Activity Evaluation of Matrinic Acid Derivatives as Potential Antiproliferative Agents
od: Jian-Jun Liu, i dr.
Izdano: (2013-05-01)

Antiviral Effect of Matrine against Human Enterovirus 71
od: Jiangning Liu, i dr.
Izdano: (2012-08-01)

Matrine induces V-ATPase-dependent cytoplasmic vacuolation and inhibits the function of the lysosome in leukemia cells
od: Fanfan Yang, i dr.
Izdano: (2024-12-01)

Matrine Restrains Cell Growth and Metastasis by Up-Regulating LINC00472 in Bladder Carcinoma
od: Li L, i dr.
Izdano: (2020-02-01)

Improvement of the Thermal Stability and Aqueous Solubility of Three Matrine Salts Assembled by the Similar Structure Salt Formers
od: Yeyang Wang, i dr.
Izdano: (2024-01-01)

Development of a Novel Electrochemical Sensor for Determination of Matrine in Sophora flavescens
od: Junping Zhang, i dr.
Izdano: (2017-04-01)

Zein nanoparticles stabilized by hydrophilic small molecule stabilizer matrine deliver curcumin effectively
od: Hong Liu, i dr.
Izdano: (2023-01-01)

Matrine Promotes Human Myeloid Leukemia Cells Apoptosis Through Warburg Effect Mediated by Hexokinase 2
od: Guibin Lin, i dr.
Izdano: (2019-09-01)

Matrine promotes mitochondrial biosynthesis and reduces oxidative stress in experimental optic neuritis
od: Yifan Song, i dr.
Izdano: (2022-09-01)

Matrine: A Promising Natural Product With Various Pharmacological Activities
od: Hong Zhang, i dr.
Izdano: (2020-05-01)

Matrine relieved DHAV-1-induced hepatocyte excessive interferon and pyroptosis by activating mitophagy
od: Weiran Wang, i dr.
Izdano: (2025-01-01)

Matrin3: Disorder and ALS Pathogenesis
od: Ahmed Salem, i dr.
Izdano: (2022-01-01)

Design, Synthesis and Various Bioactivity of Acylhydrazone-Containing Matrine Analogues
od: Wanjun Ni, i dr.
Izdano: (2023-05-01)

RETRACTED: Matrine Protects Cardiomyocytes Against Hyperglycemic Stress by Promoting Mitofusin 2-Induced Mitochondrial Fusion
od: Tong Xiao, i dr.
Izdano: (2021-02-01)

Synthesis of Halopyrazole Matrine Derivatives and Their Insecticidal and Fungicidal Activities
od: Xingan Cheng, i dr.
Izdano: (2022-08-01)

Matrine Enhances the Pathogenicity of Beauveria brongniartii Against Spodoptera litura (Lepidoptera: Noctuidae)
od: Jianhui Wu, i dr.
Izdano: (2019-08-01)

Self-Assembly of Rhein and Matrine Nanoparticles for Enhanced Wound Healing
od: Xunxun Wu, i dr.
Izdano: (2024-07-01)

Matrine family derivatives: Synthesis, reactions procedures, mechanism, and application in medicinal, agricultural, and materials chemistry
od: Jamal A.H. Kowah, i dr.
Izdano: (2023-04-01)

The Effects of Matrine in Combination with Docetaxel on Castration-Resistant (Androgen-Independent) Prostate Cancer
od: Li Q, i dr.
Izdano: (2019-12-01)

14-Thienyl Methylene Matrine (YYJ18), the Derivative from Matrine, Induces Apoptosis of Human Nasopharyngeal Carcinoma Cells by Targeting MAPK and PI3K/Akt Pathways in Vitro
od: Mao Xie, i dr.
Izdano: (2014-05-01)

Autophagy inhibition enhances Matrine derivative MASM induced apoptosis in cancer cells via a mechanism involving reactive oxygen species-mediated PI3K/Akt/mTOR and Erk/p38 signaling
od: Yuming Zou, i dr.
Izdano: (2019-10-01)

Hepatoprotective effect of Matrine salvianolic acid B salt on Carbon Tetrachloride-Induced Hepatic Fibrosis
od: Gao Hong-Ying, i dr.
Izdano: (2012-05-01)

The combined usage of Matrine and Osthole inhibited endoplasmic reticulum apoptosis induced by PCV2
od: Yinlan Xu, i dr.
Izdano: (2020-10-01)

Matrine and icariin can inhibit bovine viral diarrhoea virus replication by promoting type I interferon response in vitro
od: Cai Dongjie, i dr.
Izdano: (2024-03-01)

Formulation of Matrine Oil-Based Suspension Concentrate for Improving the Wetting of Droplets and Spraying Performance
od: Meng Li, i dr.
Izdano: (2023-07-01)

Matrine, a potential c-Myc inhibitor, suppresses ribosome biogenesis and nucleotide metabolism in myeloid leukemia
od: Wang-Jing Zhong, i dr.
Izdano: (2022-10-01)

Effect of Matrine on growth performance, gut health, and gut microbiota in chickens infected with avian pathogenic Escherichia coli
od: Ningning Mao, i dr.
Izdano: (2025-01-01)