Urinary Malondialdehyde (MDA) Concentrations in the General Population—A Systematic Literature Review and Meta-Analysis
Oxidative stress has been associated with various inflammation-related human diseases. It is defined as an imbalance between the production and elimination of reactive oxygen species (ROS). ROS can oxidize proteins, lipids, and DNA, and some of these oxidized products are excreted in urine, such as...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-03-01
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| Series: | Toxics |
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| Online Access: | https://www.mdpi.com/2305-6304/10/4/160 |
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| author | Antonio Toto Pascal Wild Mélanie Graille Veronica Turcu Camille Crézé Maud Hemmendinger Jean-Jacques Sauvain Enrico Bergamaschi Irina Guseva Canu Nancy B. Hopf |
| author_facet | Antonio Toto Pascal Wild Mélanie Graille Veronica Turcu Camille Crézé Maud Hemmendinger Jean-Jacques Sauvain Enrico Bergamaschi Irina Guseva Canu Nancy B. Hopf |
| author_sort | Antonio Toto |
| collection | DOAJ |
| description | Oxidative stress has been associated with various inflammation-related human diseases. It is defined as an imbalance between the production and elimination of reactive oxygen species (ROS). ROS can oxidize proteins, lipids, and DNA, and some of these oxidized products are excreted in urine, such as malondialdehyde (MDA), which is considered a biomarker for oxidative damage of lipids. To interpret changes of this biomarker as a measure of oxidative species overproduction in humans, a background range for urinary MDA concentration in the general population is needed. We sought to establish urinary MDA concentration ranges for healthy adult populations based on reported values in the available scientific literature. We conducted a systematic review and meta-analysis using the standardized protocol registered in PROSPERO (CRD42020146623). EMBASE, PubMed, Web of Science, and Cochrane library databases were searched from journal inception up to October 2020. We included 35 studies (divided into 47 subgroups for the quantitative analysis). Only studies that measured creatinine-corrected urinary MDA with high-performance liquid chromatography (HPLC) with mass spectrometry (MS), fluorescence detection, or UV photometry were included. The geometric mean (GM) of urinary MDA concentration was 0.10 mg/g creatinine and 95% percentile confidence interval (CI) 0.07–0.12. Age, geographical location but not sex, and smoking status had a significant effect on urinary MDA concentrations. There was a significant increasing trend of urinary MDA concentrations with age. These urinary MDA values should be considered preliminary, as they are based on mostly moderate to some low-quality evidence studies. Although urinary MDA can reliably reflect excessive oxidative stress in a population, the influence of physiological parameters that affect its meaning needs to be addressed as well as harmonizing the chemical analytical methods. |
| first_indexed | 2024-03-09T12:56:05Z |
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| institution | Directory Open Access Journal |
| issn | 2305-6304 |
| language | English |
| last_indexed | 2024-03-09T12:56:05Z |
| publishDate | 2022-03-01 |
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| series | Toxics |
| spelling | doaj.art-94e4bba78e32419bbc71b7b46b11a3c22023-11-30T22:00:43ZengMDPI AGToxics2305-63042022-03-0110416010.3390/toxics10040160Urinary Malondialdehyde (MDA) Concentrations in the General Population—A Systematic Literature Review and Meta-AnalysisAntonio Toto0Pascal Wild1Mélanie Graille2Veronica Turcu3Camille Crézé4Maud Hemmendinger5Jean-Jacques Sauvain6Enrico Bergamaschi7Irina Guseva Canu8Nancy B. Hopf9Center for Primary Care and Public Health (Unisanté), University of Lausanne, Route de la Corniche 2, 1066 Lausanne, SwitzerlandCenter for Primary Care and Public Health (Unisanté), University of Lausanne, Route de la Corniche 2, 1066 Lausanne, SwitzerlandCenter for Primary Care and Public Health (Unisanté), University of Lausanne, Route de la Corniche 2, 1066 Lausanne, SwitzerlandCenter for Primary Care and Public Health (Unisanté), University of Lausanne, Route de la Corniche 2, 1066 Lausanne, SwitzerlandCenter for Primary Care and Public Health (Unisanté), University of Lausanne, Route de la Corniche 2, 1066 Lausanne, SwitzerlandCenter for Primary Care and Public Health (Unisanté), University of Lausanne, Route de la Corniche 2, 1066 Lausanne, SwitzerlandCenter for Primary Care and Public Health (Unisanté), University of Lausanne, Route de la Corniche 2, 1066 Lausanne, SwitzerlandLaboratory of Toxicology and Industrial Epidemiology, Department of Public Health and Pediatrics, University of Turin, Via Zuretti 29, 10125 Turin, ItalyCenter for Primary Care and Public Health (Unisanté), University of Lausanne, Route de la Corniche 2, 1066 Lausanne, SwitzerlandCenter for Primary Care and Public Health (Unisanté), University of Lausanne, Route de la Corniche 2, 1066 Lausanne, SwitzerlandOxidative stress has been associated with various inflammation-related human diseases. It is defined as an imbalance between the production and elimination of reactive oxygen species (ROS). ROS can oxidize proteins, lipids, and DNA, and some of these oxidized products are excreted in urine, such as malondialdehyde (MDA), which is considered a biomarker for oxidative damage of lipids. To interpret changes of this biomarker as a measure of oxidative species overproduction in humans, a background range for urinary MDA concentration in the general population is needed. We sought to establish urinary MDA concentration ranges for healthy adult populations based on reported values in the available scientific literature. We conducted a systematic review and meta-analysis using the standardized protocol registered in PROSPERO (CRD42020146623). EMBASE, PubMed, Web of Science, and Cochrane library databases were searched from journal inception up to October 2020. We included 35 studies (divided into 47 subgroups for the quantitative analysis). Only studies that measured creatinine-corrected urinary MDA with high-performance liquid chromatography (HPLC) with mass spectrometry (MS), fluorescence detection, or UV photometry were included. The geometric mean (GM) of urinary MDA concentration was 0.10 mg/g creatinine and 95% percentile confidence interval (CI) 0.07–0.12. Age, geographical location but not sex, and smoking status had a significant effect on urinary MDA concentrations. There was a significant increasing trend of urinary MDA concentrations with age. These urinary MDA values should be considered preliminary, as they are based on mostly moderate to some low-quality evidence studies. Although urinary MDA can reliably reflect excessive oxidative stress in a population, the influence of physiological parameters that affect its meaning needs to be addressed as well as harmonizing the chemical analytical methods.https://www.mdpi.com/2305-6304/10/4/160oxidative stressMDAsystematic reviewmeta-analysisurinary biomarkerreference range |
| spellingShingle | Antonio Toto Pascal Wild Mélanie Graille Veronica Turcu Camille Crézé Maud Hemmendinger Jean-Jacques Sauvain Enrico Bergamaschi Irina Guseva Canu Nancy B. Hopf Urinary Malondialdehyde (MDA) Concentrations in the General Population—A Systematic Literature Review and Meta-Analysis Toxics oxidative stress MDA systematic review meta-analysis urinary biomarker reference range |
| title | Urinary Malondialdehyde (MDA) Concentrations in the General Population—A Systematic Literature Review and Meta-Analysis |
| title_full | Urinary Malondialdehyde (MDA) Concentrations in the General Population—A Systematic Literature Review and Meta-Analysis |
| title_fullStr | Urinary Malondialdehyde (MDA) Concentrations in the General Population—A Systematic Literature Review and Meta-Analysis |
| title_full_unstemmed | Urinary Malondialdehyde (MDA) Concentrations in the General Population—A Systematic Literature Review and Meta-Analysis |
| title_short | Urinary Malondialdehyde (MDA) Concentrations in the General Population—A Systematic Literature Review and Meta-Analysis |
| title_sort | urinary malondialdehyde mda concentrations in the general population a systematic literature review and meta analysis |
| topic | oxidative stress MDA systematic review meta-analysis urinary biomarker reference range |
| url | https://www.mdpi.com/2305-6304/10/4/160 |
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