Celastrol Efficacy by Oral Administration in the Adjuvant-Induced Arthritis Model

Celastrol Efficacy by Oral Administration in the Adjuvant-Induced Arthritis Model

Background: We previously demonstrated that celastrol has significant anti-inflammatory and bone protective effects when administered via the intraperitoneal route. For further preclinical evaluation, an effective oral administration of celastrol is crucial. Here we aimed to study the therapeutic do...

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Bibliographic Details
Main Authors: Rita Cascão, Bruno Vidal, Tânia Carvalho, Inês Pascoal Lopes, Vasco C. Romão, João Goncalves, Luis Ferreira Moita, João Eurico Fonseca
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Medicine
Subjects:
rheumatoid arthritis
adjuvant-induced arthritis
celastrol
dose
efficacy
Online Access:https://www.frontiersin.org/article/10.3389/fmed.2020.00455/full

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