Conformational Plasticity in Broadly Neutralizing HIV-1 Antibodies Triggers Polyreactivity

Conformational Plasticity in Broadly Neutralizing HIV-1 Antibodies Triggers Polyreactivity

Human high-affinity antibodies to pathogens often recognize unrelated ligands. The molecular origin and the role of this polyreactivity are largely unknown. Here, we report that HIV-1 broadly neutralizing antibodies (bNAbs) are frequently polyreactive, cross-reacting with non-HIV-1 molecules, includ...

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Bibliographic Details
Main Authors: Julie Prigent, Annaëlle Jarossay, Cyril Planchais, Caroline Eden, Jérémy Dufloo, Ayrin Kök, Valérie Lorin, Oxana Vratskikh, Thérèse Couderc, Timothée Bruel, Olivier Schwartz, Michael S. Seaman, Oliver Ohlenschläger, Jordan D. Dimitrov, Hugo Mouquet
Format: Article
Language:English
Published: Elsevier 2018-05-01
Series:Cell Reports
Subjects:
antibody
B cells
HIV-1
polyreactivity
autoreactivity
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124718306995

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