PGC-1α in Disease: Recent Renal Insights into a Versatile Metabolic Regulator
Peroxisome proliferator-activated receptor gamma co-activator 1 alpha (PGC-1α) is perhaps best known as a master regulator of mitochondrial biogenesis and function. However, by virtue of its interactions as a coactivator for numerous nuclear receptors and transcription factors, PGC-1α also regulates...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2020-10-01
|
| Series: | Cells |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2073-4409/9/10/2234 |
| _version_ | 1797551845942493184 |
|---|---|
| author | Joseph M. Chambers Rebecca A. Wingert |
| author_facet | Joseph M. Chambers Rebecca A. Wingert |
| author_sort | Joseph M. Chambers |
| collection | DOAJ |
| description | Peroxisome proliferator-activated receptor gamma co-activator 1 alpha (PGC-1α) is perhaps best known as a master regulator of mitochondrial biogenesis and function. However, by virtue of its interactions as a coactivator for numerous nuclear receptors and transcription factors, PGC-1α also regulates many tissue-specific tasks that include adipogenesis, angiogenesis, gluconeogenesis, heme biosynthesis, thermogenesis, and cellular protection against degeneration. Knowledge about these functions continue to be discovered with ongoing research. Unsurprisingly, alterations in PGC-1α expression lead to a range of deleterious outcomes. In this review, we provide a brief background on the PGC-1 family with an overview of PGC-1α’s roles as an adaptive link to meet cellular needs and its pathological consequences in several organ contexts. Among the latter, kidney health is especially reliant on PGC-1α. Thus, we discuss here at length how changes in PGC-1α function impact the states of renal cancer, acute kidney injury (AKI) and chronic kidney disease (CKD), as well as emerging data that illuminate pivotal roles for PGC-1α during renal development. We survey a new intriguing association of PGC-1α function with ciliogenesis and polycystic kidney disease (PKD), where recent animal studies revealed that embryonic renal cyst formation can occur in the context of PGC-1α deficiency. Finally, we explore future prospects for PGC-1α research and therapeutic implications for this multifaceted coactivator. |
| first_indexed | 2024-03-10T15:51:54Z |
| format | Article |
| id | doaj.art-94e9ca01c3984cd697a5463e949c593e |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T15:51:54Z |
| publishDate | 2020-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-94e9ca01c3984cd697a5463e949c593e2023-11-20T15:59:56ZengMDPI AGCells2073-44092020-10-01910223410.3390/cells9102234PGC-1α in Disease: Recent Renal Insights into a Versatile Metabolic RegulatorJoseph M. Chambers0Rebecca A. Wingert1College of Pharmacy, Natural and Health Sciences, Manchester University, Fort Wayne, IN 46845, USADepartment of Biological Sciences, Center for Stem Cells and Regenerative Medicine, Center for Zebrafish Research, Boler-Parseghian Center for Rare and Neglected Diseases, University of Notre Dame, Notre Dame, IN 46556, USAPeroxisome proliferator-activated receptor gamma co-activator 1 alpha (PGC-1α) is perhaps best known as a master regulator of mitochondrial biogenesis and function. However, by virtue of its interactions as a coactivator for numerous nuclear receptors and transcription factors, PGC-1α also regulates many tissue-specific tasks that include adipogenesis, angiogenesis, gluconeogenesis, heme biosynthesis, thermogenesis, and cellular protection against degeneration. Knowledge about these functions continue to be discovered with ongoing research. Unsurprisingly, alterations in PGC-1α expression lead to a range of deleterious outcomes. In this review, we provide a brief background on the PGC-1 family with an overview of PGC-1α’s roles as an adaptive link to meet cellular needs and its pathological consequences in several organ contexts. Among the latter, kidney health is especially reliant on PGC-1α. Thus, we discuss here at length how changes in PGC-1α function impact the states of renal cancer, acute kidney injury (AKI) and chronic kidney disease (CKD), as well as emerging data that illuminate pivotal roles for PGC-1α during renal development. We survey a new intriguing association of PGC-1α function with ciliogenesis and polycystic kidney disease (PKD), where recent animal studies revealed that embryonic renal cyst formation can occur in the context of PGC-1α deficiency. Finally, we explore future prospects for PGC-1α research and therapeutic implications for this multifaceted coactivator.https://www.mdpi.com/2073-4409/9/10/2234PGC-1α, diseasekidneycancerAKICKDnephron |
| spellingShingle | Joseph M. Chambers Rebecca A. Wingert PGC-1α in Disease: Recent Renal Insights into a Versatile Metabolic Regulator Cells PGC-1α, disease kidney cancer AKI CKD nephron |
| title | PGC-1α in Disease: Recent Renal Insights into a Versatile Metabolic Regulator |
| title_full | PGC-1α in Disease: Recent Renal Insights into a Versatile Metabolic Regulator |
| title_fullStr | PGC-1α in Disease: Recent Renal Insights into a Versatile Metabolic Regulator |
| title_full_unstemmed | PGC-1α in Disease: Recent Renal Insights into a Versatile Metabolic Regulator |
| title_short | PGC-1α in Disease: Recent Renal Insights into a Versatile Metabolic Regulator |
| title_sort | pgc 1α in disease recent renal insights into a versatile metabolic regulator |
| topic | PGC-1α, disease kidney cancer AKI CKD nephron |
| url | https://www.mdpi.com/2073-4409/9/10/2234 |
| work_keys_str_mv | AT josephmchambers pgc1aindiseaserecentrenalinsightsintoaversatilemetabolicregulator AT rebeccaawingert pgc1aindiseaserecentrenalinsightsintoaversatilemetabolicregulator |