Thickened Retinal Nerve Fiber Layers Associated With High-Altitude Headache
Purpose: This study aimed to quantify the different quadrants of the optic nerve head (ONH) and macular parameters and their changes during exposure to high altitude, and to assess their correlation with high-altitude headache (HAH).Methods: Spectral-domain optical coherence tomography (OCT) was use...
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Frontiers Media S.A.
2022-05-01
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| Series: | Frontiers in Physiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphys.2022.864222/full |
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| author | Xianhong Yin Yi Li Yi Li Yi Li Yanyun Ma Yanyun Ma Yuan Xie Kun Wang Dayan Sun Xiaoyu Liu Meng Hao Meng Liang Shixuan Zhang Yuan Guo Li Jin Li Jin Li Jin Li Jin Ningli Wang Jiucun Wang Jiucun Wang |
| author_facet | Xianhong Yin Yi Li Yi Li Yi Li Yanyun Ma Yanyun Ma Yuan Xie Kun Wang Dayan Sun Xiaoyu Liu Meng Hao Meng Liang Shixuan Zhang Yuan Guo Li Jin Li Jin Li Jin Li Jin Ningli Wang Jiucun Wang Jiucun Wang |
| author_sort | Xianhong Yin |
| collection | DOAJ |
| description | Purpose: This study aimed to quantify the different quadrants of the optic nerve head (ONH) and macular parameters and their changes during exposure to high altitude, and to assess their correlation with high-altitude headache (HAH).Methods: Spectral-domain optical coherence tomography (OCT) was used to quantify changes in the retinal structure in 109 healthy subjects during acute exposure to high altitude (3,700 m). Self-reported symptoms of HAH and acute mountain sickness AMS were assessed using Lake Louise Score (LLS), alongside measurements of physiological parameters (oxygen saturation [SpO2], heart rate [HR], hemoglobin level [Hb], and red blood cell [RBC] count). Measurements were taken before and after exposure to the high-altitude environment. The correlations of these parameters and changes at ONH were examined.Results: With the exposure to high altitude, the incidence of AMS was 44.0% and the frequency of HAH was 67.0% (54.1% mild, 12.9% moderate-severe). As for systemic parameters measured at high altitude, the participants exhibited significantly lower SpO2, higher resting HR, higher Hb, and a higher RBC (all p < 0.05). Key stereometric parameters used to describe ONH [superior, inferior, nasal, temporal, and mean retinal nerve fiber layer (RNFL) thickness] and macula (macular thickness) increased at high altitude compared with baseline. Most parameters of ONH changed, especially superior, inferior, and mean RNFL thickness (p < 0.05). There was a significant correlation between the ratios of RNFL at ONH and HAH [mean thickness (r = 0.246, p = 0.01); inferior (r = 0.216, p = 0.02); nasal (r = 0.193, p = 0.04)]. No associations between parameters of ONH and AMS or LLS were observed.Conclusion: The high-altitude environment can increase RNFL thickness at ONH. Furthermore, we found that the ratios of mean thickness, inferior area, and nasal area correlated positively with HAH, which provides new insights for understanding of the underlying pathological mechanisms of high-altitude retinopathy (HAR). |
| first_indexed | 2024-12-12T04:04:58Z |
| format | Article |
| id | doaj.art-94ecf9717f134596af70e34d1e8cefd2 |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-12-12T04:04:58Z |
| publishDate | 2022-05-01 |
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| series | Frontiers in Physiology |
| spelling | doaj.art-94ecf9717f134596af70e34d1e8cefd22022-12-22T00:38:48ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2022-05-011310.3389/fphys.2022.864222864222Thickened Retinal Nerve Fiber Layers Associated With High-Altitude HeadacheXianhong Yin0Yi Li1Yi Li2Yi Li3Yanyun Ma4Yanyun Ma5Yuan Xie6Kun Wang7Dayan Sun8Xiaoyu Liu9Meng Hao10Meng Liang11Shixuan Zhang12Yuan Guo13Li Jin14Li Jin15Li Jin16Li Jin17Ningli Wang18Jiucun Wang19Jiucun Wang20Ministry of Education Key Laboratory of Contemporary Anthropology, School of Life Sciences, and Human Phenome Institute, Fudan University, Shanghai, ChinaMinistry of Education Key Laboratory of Contemporary Anthropology, School of Life Sciences, and Human Phenome Institute, Fudan University, Shanghai, ChinaInstitute for Six-Sector Economy, Fudan University, Shanghai, ChinaInternational Human Phenome Institutes, Shanghai, ChinaMinistry of Education Key Laboratory of Contemporary Anthropology, School of Life Sciences, and Human Phenome Institute, Fudan University, Shanghai, ChinaInstitute for Six-Sector Economy, Fudan University, Shanghai, ChinaBeijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, ChinaMinistry of Education Key Laboratory of Contemporary Anthropology, School of Life Sciences, and Human Phenome Institute, Fudan University, Shanghai, ChinaMinistry of Education Key Laboratory of Contemporary Anthropology, School of Life Sciences, and Human Phenome Institute, Fudan University, Shanghai, ChinaMinistry of Education Key Laboratory of Contemporary Anthropology, School of Life Sciences, and Human Phenome Institute, Fudan University, Shanghai, ChinaMinistry of Education Key Laboratory of Contemporary Anthropology, School of Life Sciences, and Human Phenome Institute, Fudan University, Shanghai, ChinaMinistry of Education Key Laboratory of Contemporary Anthropology, School of Life Sciences, and Human Phenome Institute, Fudan University, Shanghai, ChinaMinistry of Education Key Laboratory of Contemporary Anthropology, School of Life Sciences, and Human Phenome Institute, Fudan University, Shanghai, ChinaMinistry of Education Key Laboratory of Contemporary Anthropology, School of Life Sciences, and Human Phenome Institute, Fudan University, Shanghai, ChinaMinistry of Education Key Laboratory of Contemporary Anthropology, School of Life Sciences, and Human Phenome Institute, Fudan University, Shanghai, ChinaInternational Human Phenome Institutes, Shanghai, ChinaResearch Institute of Data Sciences, Fudan University, Shanghai, ChinaResearch Unit of Dissecting the Population Genetics and Developing New Technologies for Treatment and Prevention of Skin Phenotypes and Dermatological Diseases, Chinese Academy of Medical Sciences (2019RU058), Shanghai, ChinaBeijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, ChinaMinistry of Education Key Laboratory of Contemporary Anthropology, School of Life Sciences, and Human Phenome Institute, Fudan University, Shanghai, ChinaResearch Unit of Dissecting the Population Genetics and Developing New Technologies for Treatment and Prevention of Skin Phenotypes and Dermatological Diseases, Chinese Academy of Medical Sciences (2019RU058), Shanghai, ChinaPurpose: This study aimed to quantify the different quadrants of the optic nerve head (ONH) and macular parameters and their changes during exposure to high altitude, and to assess their correlation with high-altitude headache (HAH).Methods: Spectral-domain optical coherence tomography (OCT) was used to quantify changes in the retinal structure in 109 healthy subjects during acute exposure to high altitude (3,700 m). Self-reported symptoms of HAH and acute mountain sickness AMS were assessed using Lake Louise Score (LLS), alongside measurements of physiological parameters (oxygen saturation [SpO2], heart rate [HR], hemoglobin level [Hb], and red blood cell [RBC] count). Measurements were taken before and after exposure to the high-altitude environment. The correlations of these parameters and changes at ONH were examined.Results: With the exposure to high altitude, the incidence of AMS was 44.0% and the frequency of HAH was 67.0% (54.1% mild, 12.9% moderate-severe). As for systemic parameters measured at high altitude, the participants exhibited significantly lower SpO2, higher resting HR, higher Hb, and a higher RBC (all p < 0.05). Key stereometric parameters used to describe ONH [superior, inferior, nasal, temporal, and mean retinal nerve fiber layer (RNFL) thickness] and macula (macular thickness) increased at high altitude compared with baseline. Most parameters of ONH changed, especially superior, inferior, and mean RNFL thickness (p < 0.05). There was a significant correlation between the ratios of RNFL at ONH and HAH [mean thickness (r = 0.246, p = 0.01); inferior (r = 0.216, p = 0.02); nasal (r = 0.193, p = 0.04)]. No associations between parameters of ONH and AMS or LLS were observed.Conclusion: The high-altitude environment can increase RNFL thickness at ONH. Furthermore, we found that the ratios of mean thickness, inferior area, and nasal area correlated positively with HAH, which provides new insights for understanding of the underlying pathological mechanisms of high-altitude retinopathy (HAR).https://www.frontiersin.org/articles/10.3389/fphys.2022.864222/fullheadachehigh-altitude headacheHAHretinal nerve fiber layerRNFLOCT |
| spellingShingle | Xianhong Yin Yi Li Yi Li Yi Li Yanyun Ma Yanyun Ma Yuan Xie Kun Wang Dayan Sun Xiaoyu Liu Meng Hao Meng Liang Shixuan Zhang Yuan Guo Li Jin Li Jin Li Jin Li Jin Ningli Wang Jiucun Wang Jiucun Wang Thickened Retinal Nerve Fiber Layers Associated With High-Altitude Headache Frontiers in Physiology headache high-altitude headache HAH retinal nerve fiber layer RNFL OCT |
| title | Thickened Retinal Nerve Fiber Layers Associated With High-Altitude Headache |
| title_full | Thickened Retinal Nerve Fiber Layers Associated With High-Altitude Headache |
| title_fullStr | Thickened Retinal Nerve Fiber Layers Associated With High-Altitude Headache |
| title_full_unstemmed | Thickened Retinal Nerve Fiber Layers Associated With High-Altitude Headache |
| title_short | Thickened Retinal Nerve Fiber Layers Associated With High-Altitude Headache |
| title_sort | thickened retinal nerve fiber layers associated with high altitude headache |
| topic | headache high-altitude headache HAH retinal nerve fiber layer RNFL OCT |
| url | https://www.frontiersin.org/articles/10.3389/fphys.2022.864222/full |
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