SARS-CoV-2 Seroprevalence in Children under 5 Years Old—A Regional Seroepidemiological Study
<i>Background and Objectives:</i> The aim of this research was to assess the spread of SARS-CoV-2 infection; the study was motivated by parental hesitancy regarding child vaccination, and the potential passive immunity of infants acquired through breastfeeding from mothers vaccinated aga...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2024-02-01
|
| Series: | Medicina |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1648-9144/60/3/384 |
| _version_ | 1797240146392776704 |
|---|---|
| author | Felicia Trofin Cătălina Luncă Diana Păduraru Dana-Teodora Anton-Păduraru Elena Roxana Buzilă Eduard Vasile Nastase Ancuta Lupu Vasile Valeriu Lupu Olivia Simona Dorneanu |
| author_facet | Felicia Trofin Cătălina Luncă Diana Păduraru Dana-Teodora Anton-Păduraru Elena Roxana Buzilă Eduard Vasile Nastase Ancuta Lupu Vasile Valeriu Lupu Olivia Simona Dorneanu |
| author_sort | Felicia Trofin |
| collection | DOAJ |
| description | <i>Background and Objectives:</i> The aim of this research was to assess the spread of SARS-CoV-2 infection; the study was motivated by parental hesitancy regarding child vaccination, and the potential passive immunity of infants acquired through breastfeeding from mothers vaccinated against COVID-19 or infected with SARS-CoV-2. <i>Materials and Methods</i>: We quantified the anti-SARS-CoV-2 immunoglobulin G (IgG) titer in the serum of 743 children under 5 years old, hospitalized between 1 August 2022, and 15 September 2023. <i>Results</i>: Among the participants, 52.76% had an anti-SARS-CoV-2 IgG titer that exceeded the reactivity threshold of the kit used, with an average of 1558.01 U/mL across the entire group. By age-specific categories, SARS-CoV-2 antibody prevalence was 43.04% for 0–12 months, 42.22% for 12–24 months, 61.67% for 24–36 months, 65.17% for 36–48 months, and 68.55% for 48–59 months. Gender analysis revealed 55.32% male participants, with a 52.07% seropositivity rate. Notably, IgG titer correlated positively with the child’s age. Gender, admission diagnosis, and emergency department presentation were not variation factors of the IgG titer. <i>Conclusions</i>: The majority of children in the study group demonstrated IgG against SARS-CoV-2, and this rate increased with the child’s age. Also, the IgG titer increased with the child’s age. |
| first_indexed | 2024-04-24T18:02:48Z |
| format | Article |
| id | doaj.art-94ef42ec3aca40ab820c35ec6ce25523 |
| institution | Directory Open Access Journal |
| issn | 1010-660X 1648-9144 |
| language | English |
| last_indexed | 2024-04-24T18:02:48Z |
| publishDate | 2024-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Medicina |
| spelling | doaj.art-94ef42ec3aca40ab820c35ec6ce255232024-03-27T13:53:28ZengMDPI AGMedicina1010-660X1648-91442024-02-0160338410.3390/medicina60030384SARS-CoV-2 Seroprevalence in Children under 5 Years Old—A Regional Seroepidemiological StudyFelicia Trofin0Cătălina Luncă1Diana Păduraru2Dana-Teodora Anton-Păduraru3Elena Roxana Buzilă4Eduard Vasile Nastase5Ancuta Lupu6Vasile Valeriu Lupu7Olivia Simona Dorneanu8Department of Preventive Medicine and Interdisciplinarity—Microbiology, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, RomaniaDepartment of Preventive Medicine and Interdisciplinarity—Microbiology, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, Romania“Dr. C.I. Parhon” Clinical Hospital, 700503 Iasi, Romania“Sf. Maria” Children Emergency Hospital, 700309 Iasi, RomaniaDepartment of Preventive Medicine and Interdisciplinarity—Microbiology, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, RomaniaDepartment of Internal Medicine II—Infectious Diseases, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, Romania“Sf. Maria” Children Emergency Hospital, 700309 Iasi, Romania“Sf. Maria” Children Emergency Hospital, 700309 Iasi, RomaniaDepartment of Preventive Medicine and Interdisciplinarity—Microbiology, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, Romania<i>Background and Objectives:</i> The aim of this research was to assess the spread of SARS-CoV-2 infection; the study was motivated by parental hesitancy regarding child vaccination, and the potential passive immunity of infants acquired through breastfeeding from mothers vaccinated against COVID-19 or infected with SARS-CoV-2. <i>Materials and Methods</i>: We quantified the anti-SARS-CoV-2 immunoglobulin G (IgG) titer in the serum of 743 children under 5 years old, hospitalized between 1 August 2022, and 15 September 2023. <i>Results</i>: Among the participants, 52.76% had an anti-SARS-CoV-2 IgG titer that exceeded the reactivity threshold of the kit used, with an average of 1558.01 U/mL across the entire group. By age-specific categories, SARS-CoV-2 antibody prevalence was 43.04% for 0–12 months, 42.22% for 12–24 months, 61.67% for 24–36 months, 65.17% for 36–48 months, and 68.55% for 48–59 months. Gender analysis revealed 55.32% male participants, with a 52.07% seropositivity rate. Notably, IgG titer correlated positively with the child’s age. Gender, admission diagnosis, and emergency department presentation were not variation factors of the IgG titer. <i>Conclusions</i>: The majority of children in the study group demonstrated IgG against SARS-CoV-2, and this rate increased with the child’s age. Also, the IgG titer increased with the child’s age.https://www.mdpi.com/1648-9144/60/3/384SARS-CoV-2COVID-19seroprevalenceIgGchildren |
| spellingShingle | Felicia Trofin Cătălina Luncă Diana Păduraru Dana-Teodora Anton-Păduraru Elena Roxana Buzilă Eduard Vasile Nastase Ancuta Lupu Vasile Valeriu Lupu Olivia Simona Dorneanu SARS-CoV-2 Seroprevalence in Children under 5 Years Old—A Regional Seroepidemiological Study Medicina SARS-CoV-2 COVID-19 seroprevalence IgG children |
| title | SARS-CoV-2 Seroprevalence in Children under 5 Years Old—A Regional Seroepidemiological Study |
| title_full | SARS-CoV-2 Seroprevalence in Children under 5 Years Old—A Regional Seroepidemiological Study |
| title_fullStr | SARS-CoV-2 Seroprevalence in Children under 5 Years Old—A Regional Seroepidemiological Study |
| title_full_unstemmed | SARS-CoV-2 Seroprevalence in Children under 5 Years Old—A Regional Seroepidemiological Study |
| title_short | SARS-CoV-2 Seroprevalence in Children under 5 Years Old—A Regional Seroepidemiological Study |
| title_sort | sars cov 2 seroprevalence in children under 5 years old a regional seroepidemiological study |
| topic | SARS-CoV-2 COVID-19 seroprevalence IgG children |
| url | https://www.mdpi.com/1648-9144/60/3/384 |
| work_keys_str_mv | AT feliciatrofin sarscov2seroprevalenceinchildrenunder5yearsoldaregionalseroepidemiologicalstudy AT catalinalunca sarscov2seroprevalenceinchildrenunder5yearsoldaregionalseroepidemiologicalstudy AT dianapaduraru sarscov2seroprevalenceinchildrenunder5yearsoldaregionalseroepidemiologicalstudy AT danateodoraantonpaduraru sarscov2seroprevalenceinchildrenunder5yearsoldaregionalseroepidemiologicalstudy AT elenaroxanabuzila sarscov2seroprevalenceinchildrenunder5yearsoldaregionalseroepidemiologicalstudy AT eduardvasilenastase sarscov2seroprevalenceinchildrenunder5yearsoldaregionalseroepidemiologicalstudy AT ancutalupu sarscov2seroprevalenceinchildrenunder5yearsoldaregionalseroepidemiologicalstudy AT vasilevaleriulupu sarscov2seroprevalenceinchildrenunder5yearsoldaregionalseroepidemiologicalstudy AT oliviasimonadorneanu sarscov2seroprevalenceinchildrenunder5yearsoldaregionalseroepidemiologicalstudy |