Sex-related differences in extracranial complications in patients with traumatic brain injury
BackgroundExtracranial complications after traumatic brain injury (TBI) are common. Their influence on outcome is uncertain. Furthermore, the role of sex on the development of extracranial complications following TBI remains poorly investigated. We aimed to investigate the incidence of extracranial...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-04-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2023.1095009/full |
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| author | Giovanna Brandi Alma Gambon-Mair Lara Selina Berther Stefan Yu Bögli Stefan Yu Bögli Simone Unseld |
| author_facet | Giovanna Brandi Alma Gambon-Mair Lara Selina Berther Stefan Yu Bögli Stefan Yu Bögli Simone Unseld |
| author_sort | Giovanna Brandi |
| collection | DOAJ |
| description | BackgroundExtracranial complications after traumatic brain injury (TBI) are common. Their influence on outcome is uncertain. Furthermore, the role of sex on the development of extracranial complications following TBI remains poorly investigated. We aimed to investigate the incidence of extracranial complications after TBI with particular focus on sex-related differences with regard to complications and their influence on outcome.MethodsThis retrospective, observational study was conducted in a level I universitary swiss trauma center. Consecutive patients with TBI admitted to the intensive care unit (ICU) between 2018 and 2021 were included. Patients’ and trauma characteristics, in-hospital complications (i.e., cardiovascular, respiratory, renal, metabolic, gastrointestinal, hematological, and infectious) as well as functional outcome 3 months after trauma were analyzed. Data was dichotomized by sex or by outcome. Univariate as well as multivariate logistic regression was performed to reveal possible associations between sex, outcome and complications.ResultsOverall, 608 patients were included (male n = 447, 73.5%). Extracranial complications occurred most frequently in cardiovascular, renal, hematological and infectious systems. Men and women suffered similarly from extracranial complications. While men needed correction of coagulopathies more often (p = 0.029), women suffered more frequently from urogenital infections (p = 0.001). Similar results were found in a subgroup of patients (n = 193) with isolated TBI. A multivariate analysis did not show extracranial complications to be independent predictors of unfavorable outcome.ConclusionExtracranial complications following TBI occur frequently during the ICU-stay, can affect almost all organ systems but are not independent predictors of unfavorable outcome. The results suggest that sex-specific strategies for early recognition of extracranial complications might not be needed in patients with TBI. |
| first_indexed | 2024-04-09T17:17:25Z |
| format | Article |
| id | doaj.art-94f29e3c5b5a4f3ebfc17b28df7363a5 |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-04-09T17:17:25Z |
| publishDate | 2023-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-94f29e3c5b5a4f3ebfc17b28df7363a52023-04-19T11:43:56ZengFrontiers Media S.A.Frontiers in Neurology1664-22952023-04-011410.3389/fneur.2023.10950091095009Sex-related differences in extracranial complications in patients with traumatic brain injuryGiovanna Brandi0Alma Gambon-Mair1Lara Selina Berther2Stefan Yu Bögli3Stefan Yu Bögli4Simone Unseld5Institute of Intensive Care Medicine, University Hospital Zurich, Zurich, SwitzerlandInstitute of Intensive Care Medicine, University Hospital Zurich, Zurich, SwitzerlandInstitute of Intensive Care Medicine, University Hospital Zurich, Zurich, SwitzerlandDepartment of Neurology, University Hospital Zurich, Zurich, SwitzerlandClinical Neuroscience Center, University Hospital Zurich, Zurich, SwitzerlandInstitute of Intensive Care Medicine, University Hospital Zurich, Zurich, SwitzerlandBackgroundExtracranial complications after traumatic brain injury (TBI) are common. Their influence on outcome is uncertain. Furthermore, the role of sex on the development of extracranial complications following TBI remains poorly investigated. We aimed to investigate the incidence of extracranial complications after TBI with particular focus on sex-related differences with regard to complications and their influence on outcome.MethodsThis retrospective, observational study was conducted in a level I universitary swiss trauma center. Consecutive patients with TBI admitted to the intensive care unit (ICU) between 2018 and 2021 were included. Patients’ and trauma characteristics, in-hospital complications (i.e., cardiovascular, respiratory, renal, metabolic, gastrointestinal, hematological, and infectious) as well as functional outcome 3 months after trauma were analyzed. Data was dichotomized by sex or by outcome. Univariate as well as multivariate logistic regression was performed to reveal possible associations between sex, outcome and complications.ResultsOverall, 608 patients were included (male n = 447, 73.5%). Extracranial complications occurred most frequently in cardiovascular, renal, hematological and infectious systems. Men and women suffered similarly from extracranial complications. While men needed correction of coagulopathies more often (p = 0.029), women suffered more frequently from urogenital infections (p = 0.001). Similar results were found in a subgroup of patients (n = 193) with isolated TBI. A multivariate analysis did not show extracranial complications to be independent predictors of unfavorable outcome.ConclusionExtracranial complications following TBI occur frequently during the ICU-stay, can affect almost all organ systems but are not independent predictors of unfavorable outcome. The results suggest that sex-specific strategies for early recognition of extracranial complications might not be needed in patients with TBI.https://www.frontiersin.org/articles/10.3389/fneur.2023.1095009/fulltraumatic brain injurysex-specificextracranial complicationssystemic complicationsintensive careoutcome |
| spellingShingle | Giovanna Brandi Alma Gambon-Mair Lara Selina Berther Stefan Yu Bögli Stefan Yu Bögli Simone Unseld Sex-related differences in extracranial complications in patients with traumatic brain injury Frontiers in Neurology traumatic brain injury sex-specific extracranial complications systemic complications intensive care outcome |
| title | Sex-related differences in extracranial complications in patients with traumatic brain injury |
| title_full | Sex-related differences in extracranial complications in patients with traumatic brain injury |
| title_fullStr | Sex-related differences in extracranial complications in patients with traumatic brain injury |
| title_full_unstemmed | Sex-related differences in extracranial complications in patients with traumatic brain injury |
| title_short | Sex-related differences in extracranial complications in patients with traumatic brain injury |
| title_sort | sex related differences in extracranial complications in patients with traumatic brain injury |
| topic | traumatic brain injury sex-specific extracranial complications systemic complications intensive care outcome |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2023.1095009/full |
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