Quantity and quality of minichromosome maintenance protein complexes couple replication licensing to genome integrity
Abstract Accurate and complete replication of genetic information is a fundamental process of every cell division. The replication licensing is the first essential step that lays the foundation for error-free genome duplication. During licensing, minichromosome maintenance protein complexes, the mol...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2024-02-01
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| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-024-05855-w |
| _version_ | 1797273540595023872 |
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| author | Anoop Kumar Yadav Hana Polasek-Sedlackova |
| author_facet | Anoop Kumar Yadav Hana Polasek-Sedlackova |
| author_sort | Anoop Kumar Yadav |
| collection | DOAJ |
| description | Abstract Accurate and complete replication of genetic information is a fundamental process of every cell division. The replication licensing is the first essential step that lays the foundation for error-free genome duplication. During licensing, minichromosome maintenance protein complexes, the molecular motors of DNA replication, are loaded to genomic sites called replication origins. The correct quantity and functioning of licensed origins are necessary to prevent genome instability associated with severe diseases, including cancer. Here, we delve into recent discoveries that shed light on the novel functions of licensed origins, the pathways necessary for their proper maintenance, and their implications for cancer therapies. |
| first_indexed | 2024-03-07T14:45:50Z |
| format | Article |
| id | doaj.art-94f680a5803a4403b428065139363514 |
| institution | Directory Open Access Journal |
| issn | 2399-3642 |
| language | English |
| last_indexed | 2024-03-07T14:45:50Z |
| publishDate | 2024-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Communications Biology |
| spelling | doaj.art-94f680a5803a4403b4280651393635142024-03-05T19:59:43ZengNature PortfolioCommunications Biology2399-36422024-02-017111410.1038/s42003-024-05855-wQuantity and quality of minichromosome maintenance protein complexes couple replication licensing to genome integrityAnoop Kumar Yadav0Hana Polasek-Sedlackova1Department of Cell Biology and Epigenetics, Institute of Biophysics of the Czech Academy of SciencesDepartment of Cell Biology and Epigenetics, Institute of Biophysics of the Czech Academy of SciencesAbstract Accurate and complete replication of genetic information is a fundamental process of every cell division. The replication licensing is the first essential step that lays the foundation for error-free genome duplication. During licensing, minichromosome maintenance protein complexes, the molecular motors of DNA replication, are loaded to genomic sites called replication origins. The correct quantity and functioning of licensed origins are necessary to prevent genome instability associated with severe diseases, including cancer. Here, we delve into recent discoveries that shed light on the novel functions of licensed origins, the pathways necessary for their proper maintenance, and their implications for cancer therapies.https://doi.org/10.1038/s42003-024-05855-w |
| spellingShingle | Anoop Kumar Yadav Hana Polasek-Sedlackova Quantity and quality of minichromosome maintenance protein complexes couple replication licensing to genome integrity Communications Biology |
| title | Quantity and quality of minichromosome maintenance protein complexes couple replication licensing to genome integrity |
| title_full | Quantity and quality of minichromosome maintenance protein complexes couple replication licensing to genome integrity |
| title_fullStr | Quantity and quality of minichromosome maintenance protein complexes couple replication licensing to genome integrity |
| title_full_unstemmed | Quantity and quality of minichromosome maintenance protein complexes couple replication licensing to genome integrity |
| title_short | Quantity and quality of minichromosome maintenance protein complexes couple replication licensing to genome integrity |
| title_sort | quantity and quality of minichromosome maintenance protein complexes couple replication licensing to genome integrity |
| url | https://doi.org/10.1038/s42003-024-05855-w |
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