Possible effects of chemokine-like factor-like MARVEL transmembrane domain-containing family on antiphospholipid syndrome
Abstract. Antiphospholipid syndrome (APS) is a systemic autoimmune disease defined by thrombotic or obstetrical events and persistent antiphospholipid antibodies (aPLs). Chemokine-like factor-like MARVEL transmembrane domain-containing family (CMTM) is widely expressed in the immune system and may c...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer
2021-07-01
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| Series: | Chinese Medical Journal |
| Online Access: | http://journals.lww.com/10.1097/CM9.0000000000001449 |
| _version_ | 1819135936336756736 |
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| author | Ying-Ying Ge Hong-Ji Duan Xiao-Li Deng Li-Shao Guo |
| author_facet | Ying-Ying Ge Hong-Ji Duan Xiao-Li Deng Li-Shao Guo |
| author_sort | Ying-Ying Ge |
| collection | DOAJ |
| description | Abstract. Antiphospholipid syndrome (APS) is a systemic autoimmune disease defined by thrombotic or obstetrical events and persistent antiphospholipid antibodies (aPLs). Chemokine-like factor-like MARVEL transmembrane domain-containing family (CMTM) is widely expressed in the immune system and may closely related to APS. This review aimed to systematically summarize the possible effects of CMTM on APS. Publications were collected from PubMed and Web of Science databases up to August 2020. CKLF, CKLFSF, CMTM, antiphospholipid syndrome, immune cells, and immune molecules were used as search criteria. Immune cells, including neutrophil, dendritic cells (DCs), T-cells, B-cells, and inflammatory cytokines, play an important role in the development of APS. Chemokine-like factor 1 (CKLF1) has a chemotactic effect on many cells and can affect the expression of inflammatory cytokines and adhesion molecules through the nuclear factor-kB (NF-kB) pathway or mitogen-activated protein kinase (MARK) pathway. CKLF1 can participate in the maturation of DCs, T lymphocyte activation, and the activation of neutrophils through the MAPK pathway. CMTM1 may act on Annexin A2 by regulating Ca2+ signaling. CMTM2 and CMTM6 are up-regulated in neutrophils of APS patients. Some CMTM family members influence the activation and accumulation of platelets. CMTM3 and CMTM7 are binding partners of B-cell linker protein (BLNK), thereby linking B cell receptor (BCR) and activating BLNK-mediated signal transduction in B cells. Moreover, CMTM3 and CMTM7 can act on DCs and B-1a cell development, respectively. CMTM may have potential effects on the development of APS by acting on immune cells and immune molecules. Thus, CMTM may act as a novel prognostic factor or immunomodulatory treatment option of APS. |
| first_indexed | 2024-12-22T10:27:00Z |
| format | Article |
| id | doaj.art-94f69d757d36470789c565cb11b01aa4 |
| institution | Directory Open Access Journal |
| issn | 0366-6999 2542-5641 |
| language | English |
| last_indexed | 2024-12-22T10:27:00Z |
| publishDate | 2021-07-01 |
| publisher | Wolters Kluwer |
| record_format | Article |
| series | Chinese Medical Journal |
| spelling | doaj.art-94f69d757d36470789c565cb11b01aa42022-12-21T18:29:28ZengWolters KluwerChinese Medical Journal0366-69992542-56412021-07-01134141661166810.1097/CM9.0000000000001449202107200-00004Possible effects of chemokine-like factor-like MARVEL transmembrane domain-containing family on antiphospholipid syndromeYing-Ying Ge0Hong-Ji Duan1Xiao-Li Deng2Li-Shao Guo3Department of Rheumatology and Immunology, Peking University Third Hospital, Beijing 100191, China.Department of Rheumatology and Immunology, Peking University Third Hospital, Beijing 100191, China.Department of Rheumatology and Immunology, Peking University Third Hospital, Beijing 100191, China.Department of Rheumatology and Immunology, Peking University Third Hospital, Beijing 100191, China.Abstract. Antiphospholipid syndrome (APS) is a systemic autoimmune disease defined by thrombotic or obstetrical events and persistent antiphospholipid antibodies (aPLs). Chemokine-like factor-like MARVEL transmembrane domain-containing family (CMTM) is widely expressed in the immune system and may closely related to APS. This review aimed to systematically summarize the possible effects of CMTM on APS. Publications were collected from PubMed and Web of Science databases up to August 2020. CKLF, CKLFSF, CMTM, antiphospholipid syndrome, immune cells, and immune molecules were used as search criteria. Immune cells, including neutrophil, dendritic cells (DCs), T-cells, B-cells, and inflammatory cytokines, play an important role in the development of APS. Chemokine-like factor 1 (CKLF1) has a chemotactic effect on many cells and can affect the expression of inflammatory cytokines and adhesion molecules through the nuclear factor-kB (NF-kB) pathway or mitogen-activated protein kinase (MARK) pathway. CKLF1 can participate in the maturation of DCs, T lymphocyte activation, and the activation of neutrophils through the MAPK pathway. CMTM1 may act on Annexin A2 by regulating Ca2+ signaling. CMTM2 and CMTM6 are up-regulated in neutrophils of APS patients. Some CMTM family members influence the activation and accumulation of platelets. CMTM3 and CMTM7 are binding partners of B-cell linker protein (BLNK), thereby linking B cell receptor (BCR) and activating BLNK-mediated signal transduction in B cells. Moreover, CMTM3 and CMTM7 can act on DCs and B-1a cell development, respectively. CMTM may have potential effects on the development of APS by acting on immune cells and immune molecules. Thus, CMTM may act as a novel prognostic factor or immunomodulatory treatment option of APS.http://journals.lww.com/10.1097/CM9.0000000000001449 |
| spellingShingle | Ying-Ying Ge Hong-Ji Duan Xiao-Li Deng Li-Shao Guo Possible effects of chemokine-like factor-like MARVEL transmembrane domain-containing family on antiphospholipid syndrome Chinese Medical Journal |
| title | Possible effects of chemokine-like factor-like MARVEL transmembrane domain-containing family on antiphospholipid syndrome |
| title_full | Possible effects of chemokine-like factor-like MARVEL transmembrane domain-containing family on antiphospholipid syndrome |
| title_fullStr | Possible effects of chemokine-like factor-like MARVEL transmembrane domain-containing family on antiphospholipid syndrome |
| title_full_unstemmed | Possible effects of chemokine-like factor-like MARVEL transmembrane domain-containing family on antiphospholipid syndrome |
| title_short | Possible effects of chemokine-like factor-like MARVEL transmembrane domain-containing family on antiphospholipid syndrome |
| title_sort | possible effects of chemokine like factor like marvel transmembrane domain containing family on antiphospholipid syndrome |
| url | http://journals.lww.com/10.1097/CM9.0000000000001449 |
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