Rifamycin W Analogues from <i>Amycolatopsis mediterranei</i> S699 Δ<i>rif</i>-<i>orf5</i> Strain

Rifamycin W Analogues from <i>Amycolatopsis mediterranei</i> S699 Δ<i>rif</i>-<i>orf5</i> Strain

Rifamycin W, the most predominant intermediate in the biosynthesis of rifamycin, needs to undergo polyketide backbone rearrangement to produce rifamycin B via an oxidative cleavage of the C-12/C-29 double bond. However, the mechanism of this putative oxidative cleavage has not been characterized yet...

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Bibliographic Details
Main Authors: Yanrong Shi, Feng Ye, Yuliang Song, Xiaochun Zhang, Chunhua Lu, Yuemao Shen
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Biomolecules
Subjects:
<i>Amycolatopsis mediterranei</i> S699
rifamycin W
polyketide backbone rearrangement
oxidative cleavage
Online Access:https://www.mdpi.com/2218-273X/11/7/920

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