Unraveling the dose-response puzzle of L. monocytogenes: A mechanistic approach
Food-borne disease outbreaks caused by Listeria monocytogenes continue to impose heavy burdens on public health in North America and globally. To explore the threat L. monocytogenes presents to the elderly, pregnant woman and immuno-compromised individuals, many studies have focused on in-host infec...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
KeAi Communications Co., Ltd.
2016-10-01
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| Series: | Infectious Disease Modelling |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S246804271630015X |
| _version_ | 1797203311089156096 |
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| author | S.M. Ashrafur Rahman Daniel Munther Aamir Fazil Ben Smith Jianhong Wu |
| author_facet | S.M. Ashrafur Rahman Daniel Munther Aamir Fazil Ben Smith Jianhong Wu |
| author_sort | S.M. Ashrafur Rahman |
| collection | DOAJ |
| description | Food-borne disease outbreaks caused by Listeria monocytogenes continue to impose heavy burdens on public health in North America and globally. To explore the threat L. monocytogenes presents to the elderly, pregnant woman and immuno-compromised individuals, many studies have focused on in-host infection mechanisms and risk evaluation in terms of dose-response outcomes. However, the connection of these two foci has received little attention, leaving risk prediction with an insufficient mechanistic basis. Consequently, there is a critical need to quantifiably link in-host infection pathways with the dose-response paradigm. To better understand these relationships, we propose a new mathematical model to describe the gastro-intestinal pathway of L. monocytogenes within the host. The model dynamics are shown to be sensitive to inoculation doses and exhibit bi-stability phenomena. Applying the model to guinea pigs, we show how it provides useful tools to identify key parameters and to inform critical values of these parameters that are pivotal in risk evaluation. Our preliminary analysis shows that the effect of gastro-environmental stress, the role of commensal microbiota and immune cells are critical for successful infection of L. monocytogenes and for dictating the shape of the dose-response curves. Keywords: L. monocytogenes, Dose-response, Mechanistic model, Bi-stable, Guinea pig |
| first_indexed | 2024-04-24T08:17:19Z |
| format | Article |
| id | doaj.art-94fb091816bd4a7b8c71bf3986db084d |
| institution | Directory Open Access Journal |
| issn | 2468-0427 |
| language | English |
| last_indexed | 2024-04-24T08:17:19Z |
| publishDate | 2016-10-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Infectious Disease Modelling |
| spelling | doaj.art-94fb091816bd4a7b8c71bf3986db084d2024-04-17T03:07:51ZengKeAi Communications Co., Ltd.Infectious Disease Modelling2468-04272016-10-0111101114Unraveling the dose-response puzzle of L. monocytogenes: A mechanistic approachS.M. Ashrafur Rahman0Daniel Munther1Aamir Fazil2Ben Smith3Jianhong Wu4Laboratory for Industrial and Applied Mathematics, Centre for Disease Modelling, Department of Mathematics and Statistics, York University, Toronto, ON M3J 1P3, Canada; Corresponding author.Department of Mathematics, Cleveland State University, Cleveland, OH 44115, United StatesNational Microbiology Laboratory, Public Health Agency of Canada, Guelph, ON N1G 5B2, CanadaNational Microbiology Laboratory, Public Health Agency of Canada, Guelph, ON N1G 5B2, CanadaLaboratory for Industrial and Applied Mathematics, Centre for Disease Modelling, Department of Mathematics and Statistics, York University, Toronto, ON M3J 1P3, CanadaFood-borne disease outbreaks caused by Listeria monocytogenes continue to impose heavy burdens on public health in North America and globally. To explore the threat L. monocytogenes presents to the elderly, pregnant woman and immuno-compromised individuals, many studies have focused on in-host infection mechanisms and risk evaluation in terms of dose-response outcomes. However, the connection of these two foci has received little attention, leaving risk prediction with an insufficient mechanistic basis. Consequently, there is a critical need to quantifiably link in-host infection pathways with the dose-response paradigm. To better understand these relationships, we propose a new mathematical model to describe the gastro-intestinal pathway of L. monocytogenes within the host. The model dynamics are shown to be sensitive to inoculation doses and exhibit bi-stability phenomena. Applying the model to guinea pigs, we show how it provides useful tools to identify key parameters and to inform critical values of these parameters that are pivotal in risk evaluation. Our preliminary analysis shows that the effect of gastro-environmental stress, the role of commensal microbiota and immune cells are critical for successful infection of L. monocytogenes and for dictating the shape of the dose-response curves. Keywords: L. monocytogenes, Dose-response, Mechanistic model, Bi-stable, Guinea pighttp://www.sciencedirect.com/science/article/pii/S246804271630015X |
| spellingShingle | S.M. Ashrafur Rahman Daniel Munther Aamir Fazil Ben Smith Jianhong Wu Unraveling the dose-response puzzle of L. monocytogenes: A mechanistic approach Infectious Disease Modelling |
| title | Unraveling the dose-response puzzle of L. monocytogenes: A mechanistic approach |
| title_full | Unraveling the dose-response puzzle of L. monocytogenes: A mechanistic approach |
| title_fullStr | Unraveling the dose-response puzzle of L. monocytogenes: A mechanistic approach |
| title_full_unstemmed | Unraveling the dose-response puzzle of L. monocytogenes: A mechanistic approach |
| title_short | Unraveling the dose-response puzzle of L. monocytogenes: A mechanistic approach |
| title_sort | unraveling the dose response puzzle of l monocytogenes a mechanistic approach |
| url | http://www.sciencedirect.com/science/article/pii/S246804271630015X |
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