Current Perspectives on the Use of off the Shelf CAR-T/NK Cells for the Treatment of Cancer
CAR T cells have revolutionised the treatment of haematological malignancies. Despite this, several obstacles still prohibit their widespread use and efficacy. One of these barriers is the use of autologous T cells as the carrier of the CAR. The individual production of CAR T cells results in large...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-04-01
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| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/13/8/1926 |
| _version_ | 1797537470857871360 |
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| author | Lauren C. Cutmore John F. Marshall |
| author_facet | Lauren C. Cutmore John F. Marshall |
| author_sort | Lauren C. Cutmore |
| collection | DOAJ |
| description | CAR T cells have revolutionised the treatment of haematological malignancies. Despite this, several obstacles still prohibit their widespread use and efficacy. One of these barriers is the use of autologous T cells as the carrier of the CAR. The individual production of CAR T cells results in large variation in the product, greater wait times for treatment and higher costs. To overcome this several novel approaches have emerged that utilise allogeneic cells, so called “off the shelf” CAR T cells. In this Review, we describe the different approaches that have been used to produce allogeneic CAR T to date, as well as their current pre-clinical and clinical progress. |
| first_indexed | 2024-03-10T12:16:37Z |
| format | Article |
| id | doaj.art-94fb393d9d604702836fad711fcc92fa |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T12:16:37Z |
| publishDate | 2021-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-94fb393d9d604702836fad711fcc92fa2023-11-21T15:50:28ZengMDPI AGCancers2072-66942021-04-01138192610.3390/cancers13081926Current Perspectives on the Use of off the Shelf CAR-T/NK Cells for the Treatment of CancerLauren C. Cutmore0John F. Marshall1Barts Cancer Institute, Cancer Research UK Centre of Excellence, Queen Mary University of London, London EC1M 6BQ, UKBarts Cancer Institute, Cancer Research UK Centre of Excellence, Queen Mary University of London, London EC1M 6BQ, UKCAR T cells have revolutionised the treatment of haematological malignancies. Despite this, several obstacles still prohibit their widespread use and efficacy. One of these barriers is the use of autologous T cells as the carrier of the CAR. The individual production of CAR T cells results in large variation in the product, greater wait times for treatment and higher costs. To overcome this several novel approaches have emerged that utilise allogeneic cells, so called “off the shelf” CAR T cells. In this Review, we describe the different approaches that have been used to produce allogeneic CAR T to date, as well as their current pre-clinical and clinical progress.https://www.mdpi.com/2072-6694/13/8/1926CAR T cellimmunotherapyadoptive cell transfer |
| spellingShingle | Lauren C. Cutmore John F. Marshall Current Perspectives on the Use of off the Shelf CAR-T/NK Cells for the Treatment of Cancer Cancers CAR T cell immunotherapy adoptive cell transfer |
| title | Current Perspectives on the Use of off the Shelf CAR-T/NK Cells for the Treatment of Cancer |
| title_full | Current Perspectives on the Use of off the Shelf CAR-T/NK Cells for the Treatment of Cancer |
| title_fullStr | Current Perspectives on the Use of off the Shelf CAR-T/NK Cells for the Treatment of Cancer |
| title_full_unstemmed | Current Perspectives on the Use of off the Shelf CAR-T/NK Cells for the Treatment of Cancer |
| title_short | Current Perspectives on the Use of off the Shelf CAR-T/NK Cells for the Treatment of Cancer |
| title_sort | current perspectives on the use of off the shelf car t nk cells for the treatment of cancer |
| topic | CAR T cell immunotherapy adoptive cell transfer |
| url | https://www.mdpi.com/2072-6694/13/8/1926 |
| work_keys_str_mv | AT laurenccutmore currentperspectivesontheuseofofftheshelfcartnkcellsforthetreatmentofcancer AT johnfmarshall currentperspectivesontheuseofofftheshelfcartnkcellsforthetreatmentofcancer |