A genome-wide comparative evolutionary analysis of herpes simplex virus type 1 and varicella zoster virus.

Herpes simplex virus type 1 (HSV-1) and varicella zoster virus (VZV) are closely related viruses causing lifelong infections. They are typically associated with mucocutaneous or skin lesions, but may also cause severe neurological or ophthalmic diseases, possibly due to viral- and/or host-genetic fa...

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Main Authors: Peter Norberg, Shaun Tyler, Alberto Severini, Rich Whitley, Jan-Åke Liljeqvist, Tomas Bergström
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3143153?pdf=render
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author Peter Norberg
Shaun Tyler
Alberto Severini
Rich Whitley
Jan-Åke Liljeqvist
Tomas Bergström
author_facet Peter Norberg
Shaun Tyler
Alberto Severini
Rich Whitley
Jan-Åke Liljeqvist
Tomas Bergström
author_sort Peter Norberg
collection DOAJ
description Herpes simplex virus type 1 (HSV-1) and varicella zoster virus (VZV) are closely related viruses causing lifelong infections. They are typically associated with mucocutaneous or skin lesions, but may also cause severe neurological or ophthalmic diseases, possibly due to viral- and/or host-genetic factors. Although these viruses are well characterized, genome-wide evolutionary studies have hitherto only been presented for VZV. Here, we present a genome-wide study on HSV-1. We also compared the evolutionary characteristics of HSV-1 with those for VZV. We demonstrate that, in contrast to VZV for which only a few ancient recombination events have been suggested, all HSV-1 genomes contain mosaic patterns of segments with different evolutionary origins. Thus, recombination seems to occur extremely frequent for HSV-1. We conclude by proposing a timescale for HSV-1 evolution, and by discussing putative underlying mechanisms for why these otherwise biologically similar viruses have such striking evolutionary differences.
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spelling doaj.art-94fc3e9b77eb4726a0471f3e4ef51ae32022-12-22T00:46:51ZengPublic Library of Science (PLoS)PLoS ONE1932-62032011-01-0167e2252710.1371/journal.pone.0022527A genome-wide comparative evolutionary analysis of herpes simplex virus type 1 and varicella zoster virus.Peter NorbergShaun TylerAlberto SeveriniRich WhitleyJan-Åke LiljeqvistTomas BergströmHerpes simplex virus type 1 (HSV-1) and varicella zoster virus (VZV) are closely related viruses causing lifelong infections. They are typically associated with mucocutaneous or skin lesions, but may also cause severe neurological or ophthalmic diseases, possibly due to viral- and/or host-genetic factors. Although these viruses are well characterized, genome-wide evolutionary studies have hitherto only been presented for VZV. Here, we present a genome-wide study on HSV-1. We also compared the evolutionary characteristics of HSV-1 with those for VZV. We demonstrate that, in contrast to VZV for which only a few ancient recombination events have been suggested, all HSV-1 genomes contain mosaic patterns of segments with different evolutionary origins. Thus, recombination seems to occur extremely frequent for HSV-1. We conclude by proposing a timescale for HSV-1 evolution, and by discussing putative underlying mechanisms for why these otherwise biologically similar viruses have such striking evolutionary differences.http://europepmc.org/articles/PMC3143153?pdf=render
spellingShingle Peter Norberg
Shaun Tyler
Alberto Severini
Rich Whitley
Jan-Åke Liljeqvist
Tomas Bergström
A genome-wide comparative evolutionary analysis of herpes simplex virus type 1 and varicella zoster virus.
PLoS ONE
title A genome-wide comparative evolutionary analysis of herpes simplex virus type 1 and varicella zoster virus.
title_full A genome-wide comparative evolutionary analysis of herpes simplex virus type 1 and varicella zoster virus.
title_fullStr A genome-wide comparative evolutionary analysis of herpes simplex virus type 1 and varicella zoster virus.
title_full_unstemmed A genome-wide comparative evolutionary analysis of herpes simplex virus type 1 and varicella zoster virus.
title_short A genome-wide comparative evolutionary analysis of herpes simplex virus type 1 and varicella zoster virus.
title_sort genome wide comparative evolutionary analysis of herpes simplex virus type 1 and varicella zoster virus
url http://europepmc.org/articles/PMC3143153?pdf=render
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