The Role of the Transcription Factor EGR1 in Cancer
Early growth response factor 1 (EGR1) is a transcription factor that is mainly involved in the processes of tissue injury, immune responses, and fibrosis. Recent studies have shown that EGR1 is closely related to the initiation and progression of cancer and may participate in tumor cell proliferatio...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-03-01
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| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2021.642547/full |
| _version_ | 1818609883093663744 |
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| author | Bin Wang Hanfei Guo Hongquan Yu Yong Chen Haiyang Xu Gang Zhao |
| author_facet | Bin Wang Hanfei Guo Hongquan Yu Yong Chen Haiyang Xu Gang Zhao |
| author_sort | Bin Wang |
| collection | DOAJ |
| description | Early growth response factor 1 (EGR1) is a transcription factor that is mainly involved in the processes of tissue injury, immune responses, and fibrosis. Recent studies have shown that EGR1 is closely related to the initiation and progression of cancer and may participate in tumor cell proliferation, invasion, and metastasis and in tumor angiogenesis. Nonetheless, the specific mechanism whereby EGR1 modulates these processes remains to be elucidated. This review article summarizes possible mechanisms of action of EGR1 in tumorigenesis and tumor progression and may serve as a reference for clinical efficacy predictions and for the discovery of new therapeutic targets. |
| first_indexed | 2024-12-16T15:05:37Z |
| format | Article |
| id | doaj.art-94fd1512581a42abbf8856d533f2adc3 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-12-16T15:05:37Z |
| publishDate | 2021-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-94fd1512581a42abbf8856d533f2adc32022-12-21T22:27:09ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2021-03-011110.3389/fonc.2021.642547642547The Role of the Transcription Factor EGR1 in CancerBin Wang0Hanfei Guo1Hongquan Yu2Yong Chen3Haiyang Xu4Gang Zhao5Department of Neurosurgery, The First Hospital of Jilin University, Changchun, ChinaCancer Center, The First Hospital of Jilin University, Changchun, ChinaDepartment of Neurosurgery, The First Hospital of Jilin University, Changchun, ChinaDepartment of Neurosurgery, The First Hospital of Jilin University, Changchun, ChinaDepartment of Neurosurgery, The First Hospital of Jilin University, Changchun, ChinaDepartment of Neurosurgery, The First Hospital of Jilin University, Changchun, ChinaEarly growth response factor 1 (EGR1) is a transcription factor that is mainly involved in the processes of tissue injury, immune responses, and fibrosis. Recent studies have shown that EGR1 is closely related to the initiation and progression of cancer and may participate in tumor cell proliferation, invasion, and metastasis and in tumor angiogenesis. Nonetheless, the specific mechanism whereby EGR1 modulates these processes remains to be elucidated. This review article summarizes possible mechanisms of action of EGR1 in tumorigenesis and tumor progression and may serve as a reference for clinical efficacy predictions and for the discovery of new therapeutic targets.https://www.frontiersin.org/articles/10.3389/fonc.2021.642547/fullEGR1cancerproliferationapoptosisangiogenesisinvasion |
| spellingShingle | Bin Wang Hanfei Guo Hongquan Yu Yong Chen Haiyang Xu Gang Zhao The Role of the Transcription Factor EGR1 in Cancer Frontiers in Oncology EGR1 cancer proliferation apoptosis angiogenesis invasion |
| title | The Role of the Transcription Factor EGR1 in Cancer |
| title_full | The Role of the Transcription Factor EGR1 in Cancer |
| title_fullStr | The Role of the Transcription Factor EGR1 in Cancer |
| title_full_unstemmed | The Role of the Transcription Factor EGR1 in Cancer |
| title_short | The Role of the Transcription Factor EGR1 in Cancer |
| title_sort | role of the transcription factor egr1 in cancer |
| topic | EGR1 cancer proliferation apoptosis angiogenesis invasion |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2021.642547/full |
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