Trabecular Bone Score as a Reliable Measure of Lumbar Spine Bone Microarchitecture in Acromegalic Patients
Although GH and IGF-1 excess has a controversial impact on bone mineral density (BMD), acromegalic patients display variable degrees of bone structure impairment. In this study, we aim to investigate the usefulness of trabecular bone score (TBS), compared to BMD, in identifying acromegalic patients...
Main Authors: | , , , , , , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2022-10-01
|
Series: | Journal of Clinical Medicine |
Subjects: | |
Online Access: | https://www.mdpi.com/2077-0383/11/21/6374 |
_version_ | 1797467795819069440 |
---|---|
author | Elena Nazzari Andrea Casabella Sabrina Paolino Claudia Campana Giuliana Corica Federica Nista Angelo Milioto Alberto Tagliafico Manuela Albertelli Mara Boschetti Marcello Bagnasco Maurizio Cutolo Diego Ferone Federico Gatto |
author_facet | Elena Nazzari Andrea Casabella Sabrina Paolino Claudia Campana Giuliana Corica Federica Nista Angelo Milioto Alberto Tagliafico Manuela Albertelli Mara Boschetti Marcello Bagnasco Maurizio Cutolo Diego Ferone Federico Gatto |
author_sort | Elena Nazzari |
collection | DOAJ |
description | Although GH and IGF-1 excess has a controversial impact on bone mineral density (BMD), acromegalic patients display variable degrees of bone structure impairment. In this study, we aim to investigate the usefulness of trabecular bone score (TBS), compared to BMD, in identifying acromegalic patients with impaired lumbar spine trabecular microarchitecture. Forty-four acromegalic patients were investigated for disease control, metabolic and gonadal status, bone metabolism parameters, and the presence of vertebral fractures (VFs). Patients and matched healthy controls underwent BMD and TBS examination. Mean TBS values were lower in patients than in controls (<i>p</i> < 0.001), without significant differences in mean lumbar and femoral BMD. TBS values were significantly higher in controlled patients compared to the uncontrolled ones (<i>p</i> = 0.012). No significant differences were found in bone markers with respect to disease control. Mean TBS or lumbar BMD did not significantly differ in patients with or without VFs (prevalence 11.4%). TBS and BMD levels were lower in hypogonadal patients compared to the eugonadal ones (<i>p</i> = 0.030 and <i>p</i> < 0.001, respectively). In conclusion, TBS values are significantly lower in patients than in controls, confirming the presence of impaired lumbar spine trabecular bone in acromegaly. Both uncontrolled disease and hypogonadism contribute to TBS deterioration in acromegaly. |
first_indexed | 2024-03-09T18:57:51Z |
format | Article |
id | doaj.art-94fd6e68ff3b4b4880329661fcb747e8 |
institution | Directory Open Access Journal |
issn | 2077-0383 |
language | English |
last_indexed | 2024-03-09T18:57:51Z |
publishDate | 2022-10-01 |
publisher | MDPI AG |
record_format | Article |
series | Journal of Clinical Medicine |
spelling | doaj.art-94fd6e68ff3b4b4880329661fcb747e82023-11-24T05:16:39ZengMDPI AGJournal of Clinical Medicine2077-03832022-10-011121637410.3390/jcm11216374Trabecular Bone Score as a Reliable Measure of Lumbar Spine Bone Microarchitecture in Acromegalic PatientsElena Nazzari0Andrea Casabella1Sabrina Paolino2Claudia Campana3Giuliana Corica4Federica Nista5Angelo Milioto6Alberto Tagliafico7Manuela Albertelli8Mara Boschetti9Marcello Bagnasco10Maurizio Cutolo11Diego Ferone12Federico Gatto13Endocrinology and Diabetology, ASL2 Savonese, 17100 Liguria, ItalyResearch Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genoa, IRCCS Ospedale Policlinico San Martino, 16132 Genoa, ItalyResearch Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genoa, IRCCS Ospedale Policlinico San Martino, 16132 Genoa, ItalyEndocrinology Unit, Department of Internal Medicine and Center of Excellence for Biomedical Research, University of Genoa, 16132 Genoa, ItalyEndocrinology Unit, Department of Internal Medicine and Center of Excellence for Biomedical Research, University of Genoa, 16132 Genoa, ItalyEndocrinology Unit, Department of Internal Medicine and Center of Excellence for Biomedical Research, University of Genoa, 16132 Genoa, ItalyEndocrinology Unit, Department of Internal Medicine and Center of Excellence for Biomedical Research, University of Genoa, 16132 Genoa, ItalyDepartment of Health Sciences (DISSAL), University of Genoa, 16132 Genoa, ItalyEndocrinology Unit, Department of Internal Medicine and Center of Excellence for Biomedical Research, University of Genoa, 16132 Genoa, ItalyEndocrinology Unit, Department of Internal Medicine and Center of Excellence for Biomedical Research, University of Genoa, 16132 Genoa, ItalyEndocrinology Unit, Department of Internal Medicine and Center of Excellence for Biomedical Research, University of Genoa, 16132 Genoa, ItalyResearch Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genoa, IRCCS Ospedale Policlinico San Martino, 16132 Genoa, ItalyEndocrinology Unit, Department of Internal Medicine and Center of Excellence for Biomedical Research, University of Genoa, 16132 Genoa, ItalyEndocrinology Unit, IRCCS Ospedale Policlinico San Martino, 16132 Genoa, ItalyAlthough GH and IGF-1 excess has a controversial impact on bone mineral density (BMD), acromegalic patients display variable degrees of bone structure impairment. In this study, we aim to investigate the usefulness of trabecular bone score (TBS), compared to BMD, in identifying acromegalic patients with impaired lumbar spine trabecular microarchitecture. Forty-four acromegalic patients were investigated for disease control, metabolic and gonadal status, bone metabolism parameters, and the presence of vertebral fractures (VFs). Patients and matched healthy controls underwent BMD and TBS examination. Mean TBS values were lower in patients than in controls (<i>p</i> < 0.001), without significant differences in mean lumbar and femoral BMD. TBS values were significantly higher in controlled patients compared to the uncontrolled ones (<i>p</i> = 0.012). No significant differences were found in bone markers with respect to disease control. Mean TBS or lumbar BMD did not significantly differ in patients with or without VFs (prevalence 11.4%). TBS and BMD levels were lower in hypogonadal patients compared to the eugonadal ones (<i>p</i> = 0.030 and <i>p</i> < 0.001, respectively). In conclusion, TBS values are significantly lower in patients than in controls, confirming the presence of impaired lumbar spine trabecular bone in acromegaly. Both uncontrolled disease and hypogonadism contribute to TBS deterioration in acromegaly.https://www.mdpi.com/2077-0383/11/21/6374acromegalytrabecular bone scoredisease controlbone mineral densityvertebral fracturesbone markers |
spellingShingle | Elena Nazzari Andrea Casabella Sabrina Paolino Claudia Campana Giuliana Corica Federica Nista Angelo Milioto Alberto Tagliafico Manuela Albertelli Mara Boschetti Marcello Bagnasco Maurizio Cutolo Diego Ferone Federico Gatto Trabecular Bone Score as a Reliable Measure of Lumbar Spine Bone Microarchitecture in Acromegalic Patients Journal of Clinical Medicine acromegaly trabecular bone score disease control bone mineral density vertebral fractures bone markers |
title | Trabecular Bone Score as a Reliable Measure of Lumbar Spine Bone Microarchitecture in Acromegalic Patients |
title_full | Trabecular Bone Score as a Reliable Measure of Lumbar Spine Bone Microarchitecture in Acromegalic Patients |
title_fullStr | Trabecular Bone Score as a Reliable Measure of Lumbar Spine Bone Microarchitecture in Acromegalic Patients |
title_full_unstemmed | Trabecular Bone Score as a Reliable Measure of Lumbar Spine Bone Microarchitecture in Acromegalic Patients |
title_short | Trabecular Bone Score as a Reliable Measure of Lumbar Spine Bone Microarchitecture in Acromegalic Patients |
title_sort | trabecular bone score as a reliable measure of lumbar spine bone microarchitecture in acromegalic patients |
topic | acromegaly trabecular bone score disease control bone mineral density vertebral fractures bone markers |
url | https://www.mdpi.com/2077-0383/11/21/6374 |
work_keys_str_mv | AT elenanazzari trabecularbonescoreasareliablemeasureoflumbarspinebonemicroarchitectureinacromegalicpatients AT andreacasabella trabecularbonescoreasareliablemeasureoflumbarspinebonemicroarchitectureinacromegalicpatients AT sabrinapaolino trabecularbonescoreasareliablemeasureoflumbarspinebonemicroarchitectureinacromegalicpatients AT claudiacampana trabecularbonescoreasareliablemeasureoflumbarspinebonemicroarchitectureinacromegalicpatients AT giulianacorica trabecularbonescoreasareliablemeasureoflumbarspinebonemicroarchitectureinacromegalicpatients AT federicanista trabecularbonescoreasareliablemeasureoflumbarspinebonemicroarchitectureinacromegalicpatients AT angelomilioto trabecularbonescoreasareliablemeasureoflumbarspinebonemicroarchitectureinacromegalicpatients AT albertotagliafico trabecularbonescoreasareliablemeasureoflumbarspinebonemicroarchitectureinacromegalicpatients AT manuelaalbertelli trabecularbonescoreasareliablemeasureoflumbarspinebonemicroarchitectureinacromegalicpatients AT maraboschetti trabecularbonescoreasareliablemeasureoflumbarspinebonemicroarchitectureinacromegalicpatients AT marcellobagnasco trabecularbonescoreasareliablemeasureoflumbarspinebonemicroarchitectureinacromegalicpatients AT mauriziocutolo trabecularbonescoreasareliablemeasureoflumbarspinebonemicroarchitectureinacromegalicpatients AT diegoferone trabecularbonescoreasareliablemeasureoflumbarspinebonemicroarchitectureinacromegalicpatients AT federicogatto trabecularbonescoreasareliablemeasureoflumbarspinebonemicroarchitectureinacromegalicpatients |