SHANK2 is a frequently amplified oncogene with evolutionarily conserved roles in regulating Hippo signaling

SHANK2 is a frequently amplified oncogene with evolutionarily conserved roles in regulating Hippo signaling

Abstract Dysfunction of the Hippo pathway enables cells to evade contact inhibition and provides advantages for cancerous overgrowth. However, for a significant portion of human cancer, how Hippo signaling is perturbed remains unknown. To answer this question, we performed a genome-wide screening fo...

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Bibliographic Details
Main Authors: Liang Xu, Peixue Li, Xue Hao, Yi Lu, Mingxian Liu, Wenqian Song, Lin Shan, Jiao Yu, Hongyu Ding, Shishuang Chen, Ailing Yang, Yi Arial Zeng, Lei Zhang, Hai Jiang
Format: Article
Language:English
Published: Oxford University Press 2020-07-01
Series:Protein & Cell
Subjects:
SHANK2
oncogene
Hippo signaling
cancer
Online Access:https://doi.org/10.1007/s13238-020-00742-6

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