Evaluation of osteogenic potential of Cissus quadrangularis on mandibular alveolar ridge distraction
Abstract Background This randomized clinical trial was designed to evaluate osteogenic potential of Cissus quadrangularis in alveolar distraction to facilitate implant installation. Material and methods Twenty patients with atrophic ridge were treated by alveolar distraction. After completing distra...
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| Format: | Article |
| Language: | English |
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BMC
2021-10-01
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| Series: | BMC Oral Health |
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| Online Access: | https://doi.org/10.1186/s12903-021-01847-y |
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| author | Alaa Abdelqader Altaweel Abdel Aziz Baiomy Abdullah Baiomy Hazem Shawky Shoshan Hisham Abbas Ahmed Abdel-Shakour Abdel-Hafiz Abd El-Hamid Gaber Amr Abdelfatah Zewail Marwa A. M. Elshiekh |
| author_facet | Alaa Abdelqader Altaweel Abdel Aziz Baiomy Abdullah Baiomy Hazem Shawky Shoshan Hisham Abbas Ahmed Abdel-Shakour Abdel-Hafiz Abd El-Hamid Gaber Amr Abdelfatah Zewail Marwa A. M. Elshiekh |
| author_sort | Alaa Abdelqader Altaweel |
| collection | DOAJ |
| description | Abstract Background This randomized clinical trial was designed to evaluate osteogenic potential of Cissus quadrangularis in alveolar distraction to facilitate implant installation. Material and methods Twenty patients with atrophic ridge were treated by alveolar distraction. After completing distractor activation, patients were randomly divided into two equal groups according to administered drug (placebo and Cissus quadrangularis group). After a consolidation period, distractors were removed and implants were inserted. Clinical evaluation was done to assess wound healing, and distractor and implant stability. Histological evaluation was performed at time of implant insertion. Radiographic evaluation was performed to assess bone volume and density after distraction, as well as, density and bone loss around implant. Results Radiographic and histological results showed that bone formation and maturation of study group were faster than that of control group. There was a significant increased bone density in distracted area and around implant in study group than control group. A significant bone loss at end of consolidation period, and around implant at end of the study was reported in control group than study group. Conclusion Cissus quadrangularis administration during the consolidation period is associated with increased osteogenic potential of distracted bone. The histological and radiographic findings of current study proved that Cissus quadrangularis not only enhances rate of new bone formation, but also bone density to withstand the biomechanical requirements of implant placement in a shorter time. Trial registration This study was retrospectively registered on www.ClinicalTrial.gov : NCT04669795-17\12\2020. |
| first_indexed | 2024-12-20T03:57:03Z |
| format | Article |
| id | doaj.art-94fe24bbcf194b8bb7bac83688310eb0 |
| institution | Directory Open Access Journal |
| issn | 1472-6831 |
| language | English |
| last_indexed | 2024-12-20T03:57:03Z |
| publishDate | 2021-10-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Oral Health |
| spelling | doaj.art-94fe24bbcf194b8bb7bac83688310eb02022-12-21T19:54:16ZengBMCBMC Oral Health1472-68312021-10-012111810.1186/s12903-021-01847-yEvaluation of osteogenic potential of Cissus quadrangularis on mandibular alveolar ridge distractionAlaa Abdelqader Altaweel0Abdel Aziz Baiomy Abdullah Baiomy1Hazem Shawky Shoshan2Hisham Abbas3Ahmed Abdel-Shakour Abdel-Hafiz4Abd El-Hamid Gaber5Amr Abdelfatah Zewail6Marwa A. M. Elshiekh7Oral and Maxillofacial Surgery Department, Faculty of Dental Medicine for Boys, Al-Azhar UniversityOral and Maxillofacial Surgery Department, Faculty of Dental Medicine for Boys, Al-Azhar UniversityOral and Maxillofacial Surgery Department, Vision CollegesOral and Maxillofacial Radiology Department, Faculty of Dentistry, Cairo UniversityOral and Dental Pathology Department, Faculty of Dental Medicine for Boys, Al-Azhar UniversityClinical Pharmacology, Department of Clinical Pharmacology, Faculty of Medicine, Menoufia UniversityBasic Sciences Department, Vision CollegesOral and Dental Biology Department, Faculty of Dental Medicine for Girls, Al-Azhar UniversityAbstract Background This randomized clinical trial was designed to evaluate osteogenic potential of Cissus quadrangularis in alveolar distraction to facilitate implant installation. Material and methods Twenty patients with atrophic ridge were treated by alveolar distraction. After completing distractor activation, patients were randomly divided into two equal groups according to administered drug (placebo and Cissus quadrangularis group). After a consolidation period, distractors were removed and implants were inserted. Clinical evaluation was done to assess wound healing, and distractor and implant stability. Histological evaluation was performed at time of implant insertion. Radiographic evaluation was performed to assess bone volume and density after distraction, as well as, density and bone loss around implant. Results Radiographic and histological results showed that bone formation and maturation of study group were faster than that of control group. There was a significant increased bone density in distracted area and around implant in study group than control group. A significant bone loss at end of consolidation period, and around implant at end of the study was reported in control group than study group. Conclusion Cissus quadrangularis administration during the consolidation period is associated with increased osteogenic potential of distracted bone. The histological and radiographic findings of current study proved that Cissus quadrangularis not only enhances rate of new bone formation, but also bone density to withstand the biomechanical requirements of implant placement in a shorter time. Trial registration This study was retrospectively registered on www.ClinicalTrial.gov : NCT04669795-17\12\2020.https://doi.org/10.1186/s12903-021-01847-yAlveolar ridgeCissusDistractionOsteogenicQuadrangularis |
| spellingShingle | Alaa Abdelqader Altaweel Abdel Aziz Baiomy Abdullah Baiomy Hazem Shawky Shoshan Hisham Abbas Ahmed Abdel-Shakour Abdel-Hafiz Abd El-Hamid Gaber Amr Abdelfatah Zewail Marwa A. M. Elshiekh Evaluation of osteogenic potential of Cissus quadrangularis on mandibular alveolar ridge distraction BMC Oral Health Alveolar ridge Cissus Distraction Osteogenic Quadrangularis |
| title | Evaluation of osteogenic potential of Cissus quadrangularis on mandibular alveolar ridge distraction |
| title_full | Evaluation of osteogenic potential of Cissus quadrangularis on mandibular alveolar ridge distraction |
| title_fullStr | Evaluation of osteogenic potential of Cissus quadrangularis on mandibular alveolar ridge distraction |
| title_full_unstemmed | Evaluation of osteogenic potential of Cissus quadrangularis on mandibular alveolar ridge distraction |
| title_short | Evaluation of osteogenic potential of Cissus quadrangularis on mandibular alveolar ridge distraction |
| title_sort | evaluation of osteogenic potential of cissus quadrangularis on mandibular alveolar ridge distraction |
| topic | Alveolar ridge Cissus Distraction Osteogenic Quadrangularis |
| url | https://doi.org/10.1186/s12903-021-01847-y |
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