Chromium and cobalt intoxication mimicking mitochondriopathy
Abstract A 53-year old male with a history of progressive visual impairment, hearing loss, peripheral neuropathy, poorly controlled diabetes mellitus, cardiomyopathy, and weight loss was referred to the rare disease center due to the suspicion of mitochondrial cytopathy. In line with mitochondrial d...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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BMC
2021-07-01
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| Series: | Neurological Research and Practice |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s42466-021-00141-0 |
| _version_ | 1818601147940732928 |
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| author | Tim W. Rattay Torsten Kluba Ludger Schöls |
| author_facet | Tim W. Rattay Torsten Kluba Ludger Schöls |
| author_sort | Tim W. Rattay |
| collection | DOAJ |
| description | Abstract A 53-year old male with a history of progressive visual impairment, hearing loss, peripheral neuropathy, poorly controlled diabetes mellitus, cardiomyopathy, and weight loss was referred to the rare disease center due to the suspicion of mitochondrial cytopathy. In line with mitochondrial dysfunction, lactate in CSF was increased. Genetic testing by whole-exome sequencing and mitochondrial DNA did not reveal a likely cause. The case remained unsolved until he developed pain in his right hip, where he had received total hip arthroplasty 12 years earlier. An orthopedic evaluation revealed substantial shrinkage of the head of the hip prosthesis. Due to metal-on-metal wear, debris chromium and cobalt levels in serum were massively increased and significantly improved with multisystemic impairment after exchanging the defective implant. |
| first_indexed | 2024-12-16T12:46:46Z |
| format | Article |
| id | doaj.art-94ff1c886cd24bcdb727ba9edb01b240 |
| institution | Directory Open Access Journal |
| issn | 2524-3489 |
| language | English |
| last_indexed | 2024-12-16T12:46:46Z |
| publishDate | 2021-07-01 |
| publisher | BMC |
| record_format | Article |
| series | Neurological Research and Practice |
| spelling | doaj.art-94ff1c886cd24bcdb727ba9edb01b2402022-12-21T22:31:16ZengBMCNeurological Research and Practice2524-34892021-07-01311410.1186/s42466-021-00141-0Chromium and cobalt intoxication mimicking mitochondriopathyTim W. Rattay0Torsten Kluba1Ludger Schöls2Department for Neurodegenerative Diseases and Hertie-Institute for Clinical Brain Research, Center for NeurologyOrthopedic Department, Klinikum DresdenDepartment for Neurodegenerative Diseases and Hertie-Institute for Clinical Brain Research, Center for NeurologyAbstract A 53-year old male with a history of progressive visual impairment, hearing loss, peripheral neuropathy, poorly controlled diabetes mellitus, cardiomyopathy, and weight loss was referred to the rare disease center due to the suspicion of mitochondrial cytopathy. In line with mitochondrial dysfunction, lactate in CSF was increased. Genetic testing by whole-exome sequencing and mitochondrial DNA did not reveal a likely cause. The case remained unsolved until he developed pain in his right hip, where he had received total hip arthroplasty 12 years earlier. An orthopedic evaluation revealed substantial shrinkage of the head of the hip prosthesis. Due to metal-on-metal wear, debris chromium and cobalt levels in serum were massively increased and significantly improved with multisystemic impairment after exchanging the defective implant.https://doi.org/10.1186/s42466-021-00141-0ChromiumCobaltIntoxicationMitochondriopathy |
| spellingShingle | Tim W. Rattay Torsten Kluba Ludger Schöls Chromium and cobalt intoxication mimicking mitochondriopathy Neurological Research and Practice Chromium Cobalt Intoxication Mitochondriopathy |
| title | Chromium and cobalt intoxication mimicking mitochondriopathy |
| title_full | Chromium and cobalt intoxication mimicking mitochondriopathy |
| title_fullStr | Chromium and cobalt intoxication mimicking mitochondriopathy |
| title_full_unstemmed | Chromium and cobalt intoxication mimicking mitochondriopathy |
| title_short | Chromium and cobalt intoxication mimicking mitochondriopathy |
| title_sort | chromium and cobalt intoxication mimicking mitochondriopathy |
| topic | Chromium Cobalt Intoxication Mitochondriopathy |
| url | https://doi.org/10.1186/s42466-021-00141-0 |
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