Comparative Metabolomics Study of the Impact of Articaine and Lidocaine on the Metabolism of SH-SY5Y Neuronal Cells

Comparative Metabolomics Study of the Impact of Articaine and Lidocaine on the Metabolism of SH-SY5Y Neuronal Cells

Articaine (ATC) and lidocaine (LDC) are the local anesthetics (LAs) currently most employed in dentistry. Cases of paresthesia, reported more frequently for ATC, have raised concerns about their potential neurotoxicity, calling for further investigation of their biological effects in neuronal cells....

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Bibliographic Details
Main Authors: Gustavo H. Rodrigues da Silva, Luís F. Mendes, Fabíola V. de Carvalho, Eneida de Paula, Iola F. Duarte
Format: Article
Language:English
Published: MDPI AG 2022-06-01
Series:Metabolites
Subjects:
local anesthetics
articaine and lidocaine
toxicometabolomics
neuronal cells
neurotoxicity
Online Access:https://www.mdpi.com/2218-1989/12/7/581

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