Circulating histone H3 levels in septic patients are associated with coagulopathy, multiple organ failure, and death: a single-center observational study
Abstract Background Nuclear histone proteins are released into the extracellular space, and act as major mediators of coagulopathy and remote organ failure in septic animals. However, the circulating histone levels in septic patients have not been precisely quantified. Methods Using a novel enzyme-l...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2019-01-01
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| Series: | Thrombosis Journal |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12959-018-0190-4 |
| _version_ | 1818516193117470720 |
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| author | Yayoi Yokoyama Takashi Ito Tomotsugu Yasuda Hiroaki Furubeppu Chinatsu Kamikokuryo Shingo Yamada Ikuro Maruyama Yasuyuki Kakihana |
| author_facet | Yayoi Yokoyama Takashi Ito Tomotsugu Yasuda Hiroaki Furubeppu Chinatsu Kamikokuryo Shingo Yamada Ikuro Maruyama Yasuyuki Kakihana |
| author_sort | Yayoi Yokoyama |
| collection | DOAJ |
| description | Abstract Background Nuclear histone proteins are released into the extracellular space, and act as major mediators of coagulopathy and remote organ failure in septic animals. However, the circulating histone levels in septic patients have not been precisely quantified. Methods Using a novel enzyme-linked immunosorbent assay for histone H3 detection, we measured the serum histone H3 levels in 85 patients admitted to the intensive care unit because of infectious diseases. We then evaluated the associations of circulating histone H3 levels with organ failure, coagulopathy, and mortality. Results Circulating histone H3 levels were significantly higher in patients with coagulopathy, and were positively correlated with numbers of organ failures. Circulating histone H3 levels were also associated with fatal outcome. Receiver-operating characteristic analyses revealed that the predictive performance of circulating histone H3 levels for mortality was higher than that of conventional inflammatory markers, including white blood cell count, C-reactive protein, and cell-free DNA. Conclusions Circulating histone H3 levels are associated with coagulopathy, multiple organ failure, and death in patients requiring intensive care because of infectious diseases. |
| first_indexed | 2024-12-11T00:38:50Z |
| format | Article |
| id | doaj.art-9500dc76080a4fc39bcb6df2819184d8 |
| institution | Directory Open Access Journal |
| issn | 1477-9560 |
| language | English |
| last_indexed | 2024-12-11T00:38:50Z |
| publishDate | 2019-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Thrombosis Journal |
| spelling | doaj.art-9500dc76080a4fc39bcb6df2819184d82022-12-22T01:27:01ZengBMCThrombosis Journal1477-95602019-01-011711710.1186/s12959-018-0190-4Circulating histone H3 levels in septic patients are associated with coagulopathy, multiple organ failure, and death: a single-center observational studyYayoi Yokoyama0Takashi Ito1Tomotsugu Yasuda2Hiroaki Furubeppu3Chinatsu Kamikokuryo4Shingo Yamada5Ikuro Maruyama6Yasuyuki Kakihana7Department of Emergency and Intensive Care Medicine, Kagoshima University Graduate School of Medical and Dental SciencesDepartment of Emergency and Intensive Care Medicine, Kagoshima University Graduate School of Medical and Dental SciencesDepartment of Emergency and Intensive Care Medicine, Kagoshima University Graduate School of Medical and Dental SciencesDepartment of Emergency and Intensive Care Medicine, Kagoshima University Graduate School of Medical and Dental SciencesDepartment of Emergency and Intensive Care Medicine, Kagoshima University Graduate School of Medical and Dental SciencesR&D Center, Shino-Test CorporationDepartment of Systems Biology in Thromboregulation, Kagoshima University Graduate School of Medical and Dental SciencesDepartment of Emergency and Intensive Care Medicine, Kagoshima University Graduate School of Medical and Dental SciencesAbstract Background Nuclear histone proteins are released into the extracellular space, and act as major mediators of coagulopathy and remote organ failure in septic animals. However, the circulating histone levels in septic patients have not been precisely quantified. Methods Using a novel enzyme-linked immunosorbent assay for histone H3 detection, we measured the serum histone H3 levels in 85 patients admitted to the intensive care unit because of infectious diseases. We then evaluated the associations of circulating histone H3 levels with organ failure, coagulopathy, and mortality. Results Circulating histone H3 levels were significantly higher in patients with coagulopathy, and were positively correlated with numbers of organ failures. Circulating histone H3 levels were also associated with fatal outcome. Receiver-operating characteristic analyses revealed that the predictive performance of circulating histone H3 levels for mortality was higher than that of conventional inflammatory markers, including white blood cell count, C-reactive protein, and cell-free DNA. Conclusions Circulating histone H3 levels are associated with coagulopathy, multiple organ failure, and death in patients requiring intensive care because of infectious diseases.http://link.springer.com/article/10.1186/s12959-018-0190-4HistoneSepsisCoagulopathyOrgan failure |
| spellingShingle | Yayoi Yokoyama Takashi Ito Tomotsugu Yasuda Hiroaki Furubeppu Chinatsu Kamikokuryo Shingo Yamada Ikuro Maruyama Yasuyuki Kakihana Circulating histone H3 levels in septic patients are associated with coagulopathy, multiple organ failure, and death: a single-center observational study Thrombosis Journal Histone Sepsis Coagulopathy Organ failure |
| title | Circulating histone H3 levels in septic patients are associated with coagulopathy, multiple organ failure, and death: a single-center observational study |
| title_full | Circulating histone H3 levels in septic patients are associated with coagulopathy, multiple organ failure, and death: a single-center observational study |
| title_fullStr | Circulating histone H3 levels in septic patients are associated with coagulopathy, multiple organ failure, and death: a single-center observational study |
| title_full_unstemmed | Circulating histone H3 levels in septic patients are associated with coagulopathy, multiple organ failure, and death: a single-center observational study |
| title_short | Circulating histone H3 levels in septic patients are associated with coagulopathy, multiple organ failure, and death: a single-center observational study |
| title_sort | circulating histone h3 levels in septic patients are associated with coagulopathy multiple organ failure and death a single center observational study |
| topic | Histone Sepsis Coagulopathy Organ failure |
| url | http://link.springer.com/article/10.1186/s12959-018-0190-4 |
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