Proteomics-wise, how similar are mouse and human platelets?
The field of proteomics and its application to platelet biology, is rapidly and promisingly developing. Platelets (and megakaryocytes) are postulated as biosensors of health and disease, and their proteome poses as a tool to identify the specific health-disease hallmarks. Furthermore, the clinical m...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2023-12-01
|
| Series: | Platelets |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/09537104.2023.2220415 |
| _version_ | 1797684083962150912 |
|---|---|
| author | Patricia Martínez-Botía Patricia Villar Graciela Carbajo-Argüelles Zacaria Jaiteh Andrea Acebes-Huerta Laura Gutiérrez |
| author_facet | Patricia Martínez-Botía Patricia Villar Graciela Carbajo-Argüelles Zacaria Jaiteh Andrea Acebes-Huerta Laura Gutiérrez |
| author_sort | Patricia Martínez-Botía |
| collection | DOAJ |
| description | The field of proteomics and its application to platelet biology, is rapidly and promisingly developing. Platelets (and megakaryocytes) are postulated as biosensors of health and disease, and their proteome poses as a tool to identify the specific health-disease hallmarks. Furthermore, the clinical management of certain pathologies where platelets are active players demands the development of alternative treatments, such is the case in patients where the balance thrombosis-bleeding is compromised, and a proteomics approach might aid at the identification of novel targets. Hereby, the mouse and human platelet proteomes and secretomes from public databases are compared, which shows that human and mouse platelets share a highly conserved proteome, considering identified proteins, and most importantly, their relative abundance. These supports, also interspecies wise, the use of the proteomics tool in the field, substantiated by a growing number of clinically relevant studies in humans or preclinical models. While the study of platelets through proteomics seems accessible and direct (i.e. noninvasive blood sampling, enucleated), there are some points of concern regarding the quality control of samples for such proteomics studies. Importantly, the quality of the generated data is improving over the years, which will allow cross-study comparisons. In parallel, the application of proteomics to the megakaryocyte compartment has a promising but long journey ahead. We foresee and encourage the application of platelet proteomics for diagnostic/prognostic purposes even beyond hematopoiesis and transfusion medicine, and as a tool that will procure the improvement of current therapies and the development of alternative treatment options. |
| first_indexed | 2024-03-12T00:25:22Z |
| format | Article |
| id | doaj.art-9503da7d20284142b891931e8da7fb2a |
| institution | Directory Open Access Journal |
| issn | 0953-7104 1369-1635 |
| language | English |
| last_indexed | 2024-03-12T00:25:22Z |
| publishDate | 2023-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Platelets |
| spelling | doaj.art-9503da7d20284142b891931e8da7fb2a2023-09-15T10:38:12ZengTaylor & Francis GroupPlatelets0953-71041369-16352023-12-0134110.1080/09537104.2023.22204152220415Proteomics-wise, how similar are mouse and human platelets?Patricia Martínez-Botía0Patricia Villar1Graciela Carbajo-Argüelles2Zacaria Jaiteh3Andrea Acebes-Huerta4Laura Gutiérrez5Instituto de Investigación Sanitaria del Principado de Asturias (ISPA)Instituto de Investigación Sanitaria del Principado de Asturias (ISPA)Instituto de Investigación Sanitaria del Principado de Asturias (ISPA)Instituto de Investigación Sanitaria del Principado de Asturias (ISPA)Instituto de Investigación Sanitaria del Principado de Asturias (ISPA)Instituto de Investigación Sanitaria del Principado de Asturias (ISPA)The field of proteomics and its application to platelet biology, is rapidly and promisingly developing. Platelets (and megakaryocytes) are postulated as biosensors of health and disease, and their proteome poses as a tool to identify the specific health-disease hallmarks. Furthermore, the clinical management of certain pathologies where platelets are active players demands the development of alternative treatments, such is the case in patients where the balance thrombosis-bleeding is compromised, and a proteomics approach might aid at the identification of novel targets. Hereby, the mouse and human platelet proteomes and secretomes from public databases are compared, which shows that human and mouse platelets share a highly conserved proteome, considering identified proteins, and most importantly, their relative abundance. These supports, also interspecies wise, the use of the proteomics tool in the field, substantiated by a growing number of clinically relevant studies in humans or preclinical models. While the study of platelets through proteomics seems accessible and direct (i.e. noninvasive blood sampling, enucleated), there are some points of concern regarding the quality control of samples for such proteomics studies. Importantly, the quality of the generated data is improving over the years, which will allow cross-study comparisons. In parallel, the application of proteomics to the megakaryocyte compartment has a promising but long journey ahead. We foresee and encourage the application of platelet proteomics for diagnostic/prognostic purposes even beyond hematopoiesis and transfusion medicine, and as a tool that will procure the improvement of current therapies and the development of alternative treatment options.http://dx.doi.org/10.1080/09537104.2023.2220415humaninterspeciesmegakaryocytesmouseplateletsproteomics |
| spellingShingle | Patricia Martínez-Botía Patricia Villar Graciela Carbajo-Argüelles Zacaria Jaiteh Andrea Acebes-Huerta Laura Gutiérrez Proteomics-wise, how similar are mouse and human platelets? Platelets human interspecies megakaryocytes mouse platelets proteomics |
| title | Proteomics-wise, how similar are mouse and human platelets? |
| title_full | Proteomics-wise, how similar are mouse and human platelets? |
| title_fullStr | Proteomics-wise, how similar are mouse and human platelets? |
| title_full_unstemmed | Proteomics-wise, how similar are mouse and human platelets? |
| title_short | Proteomics-wise, how similar are mouse and human platelets? |
| title_sort | proteomics wise how similar are mouse and human platelets |
| topic | human interspecies megakaryocytes mouse platelets proteomics |
| url | http://dx.doi.org/10.1080/09537104.2023.2220415 |
| work_keys_str_mv | AT patriciamartinezbotia proteomicswisehowsimilararemouseandhumanplatelets AT patriciavillar proteomicswisehowsimilararemouseandhumanplatelets AT gracielacarbajoarguelles proteomicswisehowsimilararemouseandhumanplatelets AT zacariajaiteh proteomicswisehowsimilararemouseandhumanplatelets AT andreaacebeshuerta proteomicswisehowsimilararemouseandhumanplatelets AT lauragutierrez proteomicswisehowsimilararemouseandhumanplatelets |