The Bulk of Autotaxin Activity Is Dispensable for Adult Mouse Life.
Autotaxin (ATX, Enpp2) is a secreted lysophospholipase D catalysing the production of lysophosphatidic acid, a pleiotropic growth factor-like lysophospholipid. Increased ATX expression has been detected in a number of chronic inflammatory diseases and different types of cancer, while genetic interve...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2015-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC4646642?pdf=render |
| _version_ | 1818126762411819008 |
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| author | Aggeliki Katsifa Eleanna Kaffe Nefeli Nikolaidou-Katsaridou Aris N Economides Susan Newbigging Colin McKerlie Vassilis Aidinis |
| author_facet | Aggeliki Katsifa Eleanna Kaffe Nefeli Nikolaidou-Katsaridou Aris N Economides Susan Newbigging Colin McKerlie Vassilis Aidinis |
| author_sort | Aggeliki Katsifa |
| collection | DOAJ |
| description | Autotaxin (ATX, Enpp2) is a secreted lysophospholipase D catalysing the production of lysophosphatidic acid, a pleiotropic growth factor-like lysophospholipid. Increased ATX expression has been detected in a number of chronic inflammatory diseases and different types of cancer, while genetic interventions have proven a role for ATX in disease pathogenesis. Therefore, ATX has emerged as a potential drug target and a large number of ATX inhibitors have been developed exhibiting promising therapeutic potential. However, the embryonic lethality of ATX null mice and the ubiquitous expression of ATX and LPA receptors in adult life question the suitability of ATX as a drug target. Here we show that inducible, ubiquitous genetic deletion of ATX in adult mice, as well as long-term potent pharmacologic inhibition, are well tolerated, alleviating potential toxicity concerns of ATX therapeutic targeting. |
| first_indexed | 2024-12-11T07:06:37Z |
| format | Article |
| id | doaj.art-95049f26c5dc423ba98e7b1066beac74 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-11T07:06:37Z |
| publishDate | 2015-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-95049f26c5dc423ba98e7b1066beac742022-12-22T01:16:28ZengPublic Library of Science (PLoS)PLoS ONE1932-62032015-01-011011e014308310.1371/journal.pone.0143083The Bulk of Autotaxin Activity Is Dispensable for Adult Mouse Life.Aggeliki KatsifaEleanna KaffeNefeli Nikolaidou-KatsaridouAris N EconomidesSusan NewbiggingColin McKerlieVassilis AidinisAutotaxin (ATX, Enpp2) is a secreted lysophospholipase D catalysing the production of lysophosphatidic acid, a pleiotropic growth factor-like lysophospholipid. Increased ATX expression has been detected in a number of chronic inflammatory diseases and different types of cancer, while genetic interventions have proven a role for ATX in disease pathogenesis. Therefore, ATX has emerged as a potential drug target and a large number of ATX inhibitors have been developed exhibiting promising therapeutic potential. However, the embryonic lethality of ATX null mice and the ubiquitous expression of ATX and LPA receptors in adult life question the suitability of ATX as a drug target. Here we show that inducible, ubiquitous genetic deletion of ATX in adult mice, as well as long-term potent pharmacologic inhibition, are well tolerated, alleviating potential toxicity concerns of ATX therapeutic targeting.http://europepmc.org/articles/PMC4646642?pdf=render |
| spellingShingle | Aggeliki Katsifa Eleanna Kaffe Nefeli Nikolaidou-Katsaridou Aris N Economides Susan Newbigging Colin McKerlie Vassilis Aidinis The Bulk of Autotaxin Activity Is Dispensable for Adult Mouse Life. PLoS ONE |
| title | The Bulk of Autotaxin Activity Is Dispensable for Adult Mouse Life. |
| title_full | The Bulk of Autotaxin Activity Is Dispensable for Adult Mouse Life. |
| title_fullStr | The Bulk of Autotaxin Activity Is Dispensable for Adult Mouse Life. |
| title_full_unstemmed | The Bulk of Autotaxin Activity Is Dispensable for Adult Mouse Life. |
| title_short | The Bulk of Autotaxin Activity Is Dispensable for Adult Mouse Life. |
| title_sort | bulk of autotaxin activity is dispensable for adult mouse life |
| url | http://europepmc.org/articles/PMC4646642?pdf=render |
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