Case report: Reversible splenial lesion syndrome caused by diquat poisoning
Diquat (DQ), chemically known as 1,1 ‘-ethylene-2,2’ -bipyridine, is a non-selective herbicide for leaf removal and drying. It has toxic effects on central nervous system cells, and toxic neurological lesions include axonal degeneration and pontine myelolysis. At the same time, DQ can also affect th...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-08-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2023.1178272/full |
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| author | Ping Dai Jin Sun Zhongkai Yu Tongyue Zhang Zixin Wen Zixin Wen Zixin Wen Tianzi Jian Lanlan Guo Lanlan Guo Aerbusili Genjiafu Aerbusili Genjiafu Baotian Kan Baotian Kan Baotian Kan Binbin Zhang Xiangdong Jian Xiangdong Jian |
| author_facet | Ping Dai Jin Sun Zhongkai Yu Tongyue Zhang Zixin Wen Zixin Wen Zixin Wen Tianzi Jian Lanlan Guo Lanlan Guo Aerbusili Genjiafu Aerbusili Genjiafu Baotian Kan Baotian Kan Baotian Kan Binbin Zhang Xiangdong Jian Xiangdong Jian |
| author_sort | Ping Dai |
| collection | DOAJ |
| description | Diquat (DQ), chemically known as 1,1 ‘-ethylene-2,2’ -bipyridine, is a non-selective herbicide for leaf removal and drying. It has toxic effects on central nervous system cells, and toxic neurological lesions include axonal degeneration and pontine myelolysis. At the same time, DQ can also affect the activity of dopaminergic nerve cells through oxidative stress, causing degeneration and reducing dopamine uptake. With the increasing application of DQ in agricultural production, the clinical reports of neurotoxicity caused by acute DQ poisoning are also increasing. At present, DQ rapid-phase-related toxic encephalopathy mainly involves the pons, midbrain, basal ganglia, thalamus and other brain regions. However, this case is unusual in that the lesion mainly involved the splenium of the corpus callosum. It is also the first time to be reported. |
| first_indexed | 2024-03-12T14:29:32Z |
| format | Article |
| id | doaj.art-95052a9cce844da1bbbb12868348cb64 |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-03-12T14:29:32Z |
| publishDate | 2023-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-95052a9cce844da1bbbb12868348cb642023-08-17T18:15:14ZengFrontiers Media S.A.Frontiers in Neurology1664-22952023-08-011410.3389/fneur.2023.11782721178272Case report: Reversible splenial lesion syndrome caused by diquat poisoningPing Dai0Jin Sun1Zhongkai Yu2Tongyue Zhang3Zixin Wen4Zixin Wen5Zixin Wen6Tianzi Jian7Lanlan Guo8Lanlan Guo9Aerbusili Genjiafu10Aerbusili Genjiafu11Baotian Kan12Baotian Kan13Baotian Kan14Binbin Zhang15Xiangdong Jian16Xiangdong Jian17Department of Poisoning and Occupational Diseases, Emergency Medicine, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, ChinaEmergency Department, Affiliated the Jianhu Clinical Medical College of Yangzhou University, Yancheng, ChinaDepartment of Emergency, Liaocheng People's Hospital, Liaocheng, Shandong, ChinaDepartment of Poisoning and Occupational Diseases, Emergency Medicine, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, ChinaDepartment of Poisoning and Occupational Diseases, Emergency Medicine, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, ChinaSchool of Nursing and Rehabilitation, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, ChinaNursing Theory and Practice Innovation Research Center of Shandong University, Jinan, Shandong, ChinaDepartment of Poisoning and Occupational Diseases, Emergency Medicine, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, ChinaDepartment of Poisoning and Occupational Diseases, Emergency Medicine, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, ChinaDepartment of Occupational and Environmental Health, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, ChinaDepartment of Poisoning and Occupational Diseases, Emergency Medicine, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, ChinaDepartment of Occupational and Environmental Health, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, ChinaSchool of Nursing and Rehabilitation, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, ChinaNursing Theory and Practice Innovation Research Center of Shandong University, Jinan, Shandong, ChinaDepartment of Geriatric Medicine and Department of Nursing, Qilu Hospital, Nursing Theory Innovation and Research Center of Shandong University, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, ChinaDepartment of Nursing, Qilu Hospital of Shandong University Dezhou Hospital, Nursing Theory Innovation and Research Center of Shandong University, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, ChinaDepartment of Poisoning and Occupational Diseases, Emergency Medicine, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, ChinaDepartment of Occupational and Environmental Health, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, ChinaDiquat (DQ), chemically known as 1,1 ‘-ethylene-2,2’ -bipyridine, is a non-selective herbicide for leaf removal and drying. It has toxic effects on central nervous system cells, and toxic neurological lesions include axonal degeneration and pontine myelolysis. At the same time, DQ can also affect the activity of dopaminergic nerve cells through oxidative stress, causing degeneration and reducing dopamine uptake. With the increasing application of DQ in agricultural production, the clinical reports of neurotoxicity caused by acute DQ poisoning are also increasing. At present, DQ rapid-phase-related toxic encephalopathy mainly involves the pons, midbrain, basal ganglia, thalamus and other brain regions. However, this case is unusual in that the lesion mainly involved the splenium of the corpus callosum. It is also the first time to be reported.https://www.frontiersin.org/articles/10.3389/fneur.2023.1178272/fulldiquatacute kidney injurytoxic encephalopathyreversible splenial lesion syndromeMRI |
| spellingShingle | Ping Dai Jin Sun Zhongkai Yu Tongyue Zhang Zixin Wen Zixin Wen Zixin Wen Tianzi Jian Lanlan Guo Lanlan Guo Aerbusili Genjiafu Aerbusili Genjiafu Baotian Kan Baotian Kan Baotian Kan Binbin Zhang Xiangdong Jian Xiangdong Jian Case report: Reversible splenial lesion syndrome caused by diquat poisoning Frontiers in Neurology diquat acute kidney injury toxic encephalopathy reversible splenial lesion syndrome MRI |
| title | Case report: Reversible splenial lesion syndrome caused by diquat poisoning |
| title_full | Case report: Reversible splenial lesion syndrome caused by diquat poisoning |
| title_fullStr | Case report: Reversible splenial lesion syndrome caused by diquat poisoning |
| title_full_unstemmed | Case report: Reversible splenial lesion syndrome caused by diquat poisoning |
| title_short | Case report: Reversible splenial lesion syndrome caused by diquat poisoning |
| title_sort | case report reversible splenial lesion syndrome caused by diquat poisoning |
| topic | diquat acute kidney injury toxic encephalopathy reversible splenial lesion syndrome MRI |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2023.1178272/full |
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