Hyaluronic Acid Injection Laryngoplasty for Unilateral Vocal Fold Paralysis—A Systematic Review and Meta-Analysis
Unilateral vocal fold paralysis (UVFP) is a common disorder that may cause glottal closure insufficiency and then hoarseness of voice and aspiration during swallowing. We conducted a systematic review and meta-analysis to evaluate whether hyaluronic acid (HA) injection laryngoplasty (IL) is an effec...
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MDPI AG
2020-11-01
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| Online Access: | https://www.mdpi.com/2073-4409/9/11/2417 |
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| author | Chen-Chi Wang Shang-Heng Wu Yu-Kang Tu Wen-Jiun Lin Shih-An Liu |
| author_facet | Chen-Chi Wang Shang-Heng Wu Yu-Kang Tu Wen-Jiun Lin Shih-An Liu |
| author_sort | Chen-Chi Wang |
| collection | DOAJ |
| description | Unilateral vocal fold paralysis (UVFP) is a common disorder that may cause glottal closure insufficiency and then hoarseness of voice and aspiration during swallowing. We conducted a systematic review and meta-analysis to evaluate whether hyaluronic acid (HA) injection laryngoplasty (IL) is an effective treatment for patients with UVFP. Comprehensive systematic searches were undertaken using PubMed, EBSCO Medline, and Cochrane Library databases. We appraised the quality of studies according to preset inclusion and exclusion criteria. The lengths of follow-up were divided into “short-term” (3 months or shorter), “medium-term” (6 months), and “long-term” (12 months or longer). We performed random-effect meta-analysis to estimate the changes in voice-related quality of life, perceptual evaluation by grading systems, voice lab analysis of maximal phonation time, and normalized glottal gap area, before and after HA IL. Fourteen studies were eligible for the final analysis. The results showed that patients’ glottal closure insufficiency could be improved; maximal phonation time could be prolonged; perceptual evaluations of the voice and quality of life were better after HA IL, but the duration of treatment effect varied among different studies. In conclusion, HA IL is an effective treatment for UVFP, which may achieve a long-term effect and therefore reduce the likelihood of requiring permanent medialization thyroplasty. |
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| id | doaj.art-950539e2374f443ca11d1b09aa7e83e7 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T15:05:15Z |
| publishDate | 2020-11-01 |
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| spelling | doaj.art-950539e2374f443ca11d1b09aa7e83e72023-11-20T19:50:06ZengMDPI AGCells2073-44092020-11-01911241710.3390/cells9112417Hyaluronic Acid Injection Laryngoplasty for Unilateral Vocal Fold Paralysis—A Systematic Review and Meta-AnalysisChen-Chi Wang0Shang-Heng Wu1Yu-Kang Tu2Wen-Jiun Lin3Shih-An Liu4School of Medicine, National Yang-Ming University, Taipei 11221, TaiwanDepartment of Otolaryngology-Head & Neck Surgery, Taichung Veterans General Hospital, Taichung 40705, TaiwanInstitute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei 100, TaiwanDepartment of Otolaryngology-Head & Neck Surgery, Taichung Veterans General Hospital, Taichung 40705, TaiwanDepartment of Otolaryngology-Head & Neck Surgery, Taichung Veterans General Hospital, Taichung 40705, TaiwanUnilateral vocal fold paralysis (UVFP) is a common disorder that may cause glottal closure insufficiency and then hoarseness of voice and aspiration during swallowing. We conducted a systematic review and meta-analysis to evaluate whether hyaluronic acid (HA) injection laryngoplasty (IL) is an effective treatment for patients with UVFP. Comprehensive systematic searches were undertaken using PubMed, EBSCO Medline, and Cochrane Library databases. We appraised the quality of studies according to preset inclusion and exclusion criteria. The lengths of follow-up were divided into “short-term” (3 months or shorter), “medium-term” (6 months), and “long-term” (12 months or longer). We performed random-effect meta-analysis to estimate the changes in voice-related quality of life, perceptual evaluation by grading systems, voice lab analysis of maximal phonation time, and normalized glottal gap area, before and after HA IL. Fourteen studies were eligible for the final analysis. The results showed that patients’ glottal closure insufficiency could be improved; maximal phonation time could be prolonged; perceptual evaluations of the voice and quality of life were better after HA IL, but the duration of treatment effect varied among different studies. In conclusion, HA IL is an effective treatment for UVFP, which may achieve a long-term effect and therefore reduce the likelihood of requiring permanent medialization thyroplasty.https://www.mdpi.com/2073-4409/9/11/2417hyaluronic acidinjection laryngoplastyunilateral vocal fold paralysismeta-analysis |
| spellingShingle | Chen-Chi Wang Shang-Heng Wu Yu-Kang Tu Wen-Jiun Lin Shih-An Liu Hyaluronic Acid Injection Laryngoplasty for Unilateral Vocal Fold Paralysis—A Systematic Review and Meta-Analysis Cells hyaluronic acid injection laryngoplasty unilateral vocal fold paralysis meta-analysis |
| title | Hyaluronic Acid Injection Laryngoplasty for Unilateral Vocal Fold Paralysis—A Systematic Review and Meta-Analysis |
| title_full | Hyaluronic Acid Injection Laryngoplasty for Unilateral Vocal Fold Paralysis—A Systematic Review and Meta-Analysis |
| title_fullStr | Hyaluronic Acid Injection Laryngoplasty for Unilateral Vocal Fold Paralysis—A Systematic Review and Meta-Analysis |
| title_full_unstemmed | Hyaluronic Acid Injection Laryngoplasty for Unilateral Vocal Fold Paralysis—A Systematic Review and Meta-Analysis |
| title_short | Hyaluronic Acid Injection Laryngoplasty for Unilateral Vocal Fold Paralysis—A Systematic Review and Meta-Analysis |
| title_sort | hyaluronic acid injection laryngoplasty for unilateral vocal fold paralysis a systematic review and meta analysis |
| topic | hyaluronic acid injection laryngoplasty unilateral vocal fold paralysis meta-analysis |
| url | https://www.mdpi.com/2073-4409/9/11/2417 |
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