Binary outcomes of enhancer activity underlie stable random monoallelic expression

Binary outcomes of enhancer activity underlie stable random monoallelic expression

Mitotically stable random monoallelic gene expression (RME) is documented for a small percentage of autosomal genes. We developed an in vivo genetic model to study the role of enhancers in RME using high-resolution single-cell analysis of natural killer (NK) cell receptor gene expression and enhance...

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Bibliographic Details
Main Authors: Djem U Kissiov, Alexander Ethell, Sean Chen, Natalie K Wolf, Chenyu Zhang, Susanna M Dang, Yeara Jo, Katrine N Madsen, Ishan Paranjpe, Angus Y Lee, Bryan Chim, Stefan A Muljo, David H Raulet
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2022-05-01
Series:eLife
Subjects:
Monoallelic
gene regulation
Ly49
NKG2D
Enhancer
Online Access:https://elifesciences.org/articles/74204

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