TNFα-Induced Oxidative Stress and Mitochondrial Dysfunction Alter Hypothalamic Neurogenesis and Promote Appetite Versus Satiety Neuropeptide Expression in Mice

TNFα-Induced Oxidative Stress and Mitochondrial Dysfunction Alter Hypothalamic Neurogenesis and Promote Appetite Versus Satiety Neuropeptide Expression in Mice

Maternal obesity results in programmed offspring hyperphagia and obesity. The increased offspring food intake is due in part to the preferential differentiation of hypothalamic neuroprogenitor cells (NPCs) to orexigenic (AgRP) vs. anorexigenic (POMC) neurons. The altered neurogenesis may involve hyp...

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Bibliographic Details
Main Authors: Mina Desai, Linsey Stiles, Adriana S. Torsoni, Marcio A. Torsoni, Orian S. Shirihai, Michael G. Ross
Format: Article
Language:English
Published: MDPI AG 2022-07-01
Series:Brain Sciences
Subjects:
Hypothalamic neuroprogenitor cells
reactive oxygen species
inflammation
proliferation
differentiation
maternal obesity
Online Access:https://www.mdpi.com/2076-3425/12/7/900

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