Antibacterial activity of cream, ointment, and emulgel of Ocimum basilicum L. essential oil against Propionibacterium acnes
Propionibacterium acnes is bacteria that is commonly found on healthy human skin. However, unbalanced hormonal conditions can lead to excessive growth of P. acnes, a bacteria causing acne. Previous research reported that Ocimum basilicum L. essential oil (BEO) has activity against P. acnes. Therefor...
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| Format: | Article |
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Universitas Gadjah Mada
2023-04-01
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| Series: | Majalah Obat Tradisional |
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| Online Access: | https://jurnal.ugm.ac.id/TradMedJ/article/view/80909 |
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| author | Iramie Duma Kencana Irianto Ismiyati Ismiyati Enggar Witaningrum Elly Nur Ayuningtyas Meilana Maria Ulfah Purwanto Purwanto |
| author_facet | Iramie Duma Kencana Irianto Ismiyati Ismiyati Enggar Witaningrum Elly Nur Ayuningtyas Meilana Maria Ulfah Purwanto Purwanto |
| author_sort | Iramie Duma Kencana Irianto |
| collection | DOAJ |
| description | Propionibacterium acnes is bacteria that is commonly found on healthy human skin. However, unbalanced hormonal conditions can lead to excessive growth of P. acnes, a bacteria causing acne. Previous research reported that Ocimum basilicum L. essential oil (BEO) has activity against P. acnes. Therefore, this study aims to make BEO into cream, ointment, and emulgel forms to determine its properties and antibacterial activity on those topical drug delivery systems. The preparations consisted of variations in BEO concentrations of 5%; 10%; and 15%. The three preparations were evaluated based on organoleptic, homogeneity, pH value, adhesion, and spreadability. The antibacterial activity test of the three preparations against P. acnes was carried out by the good diffusion method with the observation of the diameter of the inhibition zone (in mm). The produced cream, ointment, and cream had a typical BEO aroma, yellowish white color, and homogeneous. Based on organoleptic consistency, the texture of the thicker and longer adhesion was ointment > emulgel > cream, respectively. The pH value of the topical preparation was 5-6 and easily leveled. Antibacterial activity against P. acnes from the strongest was ointment > cream > emulgel, with a value of 14,30 + 0,30 mm; 10,54 + 0,01 mm; 3,90 + 0,04 mm, respectively. |
| first_indexed | 2024-03-12T21:02:09Z |
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| id | doaj.art-950861e43e7f4f809c810afc55b18ae4 |
| institution | Directory Open Access Journal |
| issn | 1410-5918 2406-9086 |
| language | English |
| last_indexed | 2025-03-21T01:17:48Z |
| publishDate | 2023-04-01 |
| publisher | Universitas Gadjah Mada |
| record_format | Article |
| series | Majalah Obat Tradisional |
| spelling | doaj.art-950861e43e7f4f809c810afc55b18ae42024-08-03T02:27:13ZengUniversitas Gadjah MadaMajalah Obat Tradisional1410-59182406-90862023-04-01281404710.22146/mot.8090933557Antibacterial activity of cream, ointment, and emulgel of Ocimum basilicum L. essential oil against Propionibacterium acnesIramie Duma Kencana Irianto0Ismiyati Ismiyati1Enggar Witaningrum2Elly Nur Ayuningtyas3Meilana Maria Ulfah4Purwanto Purwanto5Pharmacy Associate’s Degree, Poltekkes Bhakti Setya Indonesia, YogyakartaPharmacy Associate’s Degree, Poltekkes Bhakti Setya Indonesia, YogyakartaPharmacy Associate’s Degree, Poltekkes Bhakti Setya Indonesia, YogyakartaPharmacy Associate’s Degree, Poltekkes Bhakti Setya Indonesia, YogyakartaPharmacy Associate’s Degree, Poltekkes Bhakti Setya Indonesia, YogyakartaFaculty of Pharmacy, Universitas Gadjah Mada, YogyakartaPropionibacterium acnes is bacteria that is commonly found on healthy human skin. However, unbalanced hormonal conditions can lead to excessive growth of P. acnes, a bacteria causing acne. Previous research reported that Ocimum basilicum L. essential oil (BEO) has activity against P. acnes. Therefore, this study aims to make BEO into cream, ointment, and emulgel forms to determine its properties and antibacterial activity on those topical drug delivery systems. The preparations consisted of variations in BEO concentrations of 5%; 10%; and 15%. The three preparations were evaluated based on organoleptic, homogeneity, pH value, adhesion, and spreadability. The antibacterial activity test of the three preparations against P. acnes was carried out by the good diffusion method with the observation of the diameter of the inhibition zone (in mm). The produced cream, ointment, and cream had a typical BEO aroma, yellowish white color, and homogeneous. Based on organoleptic consistency, the texture of the thicker and longer adhesion was ointment > emulgel > cream, respectively. The pH value of the topical preparation was 5-6 and easily leveled. Antibacterial activity against P. acnes from the strongest was ointment > cream > emulgel, with a value of 14,30 + 0,30 mm; 10,54 + 0,01 mm; 3,90 + 0,04 mm, respectively.https://jurnal.ugm.ac.id/TradMedJ/article/view/80909creamemulgelocimum basilicum l.ointmentpropionibacterium acnes |
| spellingShingle | Iramie Duma Kencana Irianto Ismiyati Ismiyati Enggar Witaningrum Elly Nur Ayuningtyas Meilana Maria Ulfah Purwanto Purwanto Antibacterial activity of cream, ointment, and emulgel of Ocimum basilicum L. essential oil against Propionibacterium acnes Majalah Obat Tradisional cream emulgel ocimum basilicum l. ointment propionibacterium acnes |
| title | Antibacterial activity of cream, ointment, and emulgel of Ocimum basilicum L. essential oil against Propionibacterium acnes |
| title_full | Antibacterial activity of cream, ointment, and emulgel of Ocimum basilicum L. essential oil against Propionibacterium acnes |
| title_fullStr | Antibacterial activity of cream, ointment, and emulgel of Ocimum basilicum L. essential oil against Propionibacterium acnes |
| title_full_unstemmed | Antibacterial activity of cream, ointment, and emulgel of Ocimum basilicum L. essential oil against Propionibacterium acnes |
| title_short | Antibacterial activity of cream, ointment, and emulgel of Ocimum basilicum L. essential oil against Propionibacterium acnes |
| title_sort | antibacterial activity of cream ointment and emulgel of ocimum basilicum l essential oil against propionibacterium acnes |
| topic | cream emulgel ocimum basilicum l. ointment propionibacterium acnes |
| url | https://jurnal.ugm.ac.id/TradMedJ/article/view/80909 |
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