Structural basis for the activation of a compact CRISPR-Cas13 nuclease
Abstract The CRISPR-Cas13 ribonucleases have been widely applied for RNA knockdown and transcriptional modulation owing to their high programmability and specificity. However, the large size of Cas13 effectors and their non-specific RNA cleavage upon target activation limit the adeno-associated viru...
Main Authors: | Xiangyu Deng, Emmanuel Osikpa, Jie Yang, Seye J. Oladeji, Jamie Smith, Xue Gao, Yang Gao |
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Format: | Article |
Language: | English |
Published: |
Nature Portfolio
2023-09-01
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Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-023-41501-5 |
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