Exposure Prioritization (<i>Ex Priori</i>): A Screening-Level High-Throughput Chemical Prioritization Tool
To estimate potential chemical risk, tools are needed to prioritize potential exposures for chemicals with minimal data. Consumer product exposures are a key pathway, and variability in consumer use patterns is an important factor. We designed <i>Ex Priori</i>, a flexible dashboard-type...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-09-01
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| Series: | Toxics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2305-6304/10/10/569 |
| _version_ | 1827647898714636288 |
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| author | Heidi F. Hubbard Caroline L. Ring Tao Hong Cara C. Henning Daniel A. Vallero Peter P. Egeghy Michael-Rock Goldsmith |
| author_facet | Heidi F. Hubbard Caroline L. Ring Tao Hong Cara C. Henning Daniel A. Vallero Peter P. Egeghy Michael-Rock Goldsmith |
| author_sort | Heidi F. Hubbard |
| collection | DOAJ |
| description | To estimate potential chemical risk, tools are needed to prioritize potential exposures for chemicals with minimal data. Consumer product exposures are a key pathway, and variability in consumer use patterns is an important factor. We designed <i>Ex Priori</i>, a flexible dashboard-type screening-level exposure model, to rapidly visualize exposure rankings from consumer product use. <i>Ex Priori</i> is Excel-based. Currently, it is parameterized for seven routes of exposure for 1108 chemicals present in 228 consumer product types. It includes toxicokinetics considerations to estimate body burden. It includes a simple framework for rapid modeling of broad changes in consumer use patterns by product category. <i>Ex Priori</i> rapidly models changes in consumer user patterns during the COVID-19 pandemic and instantly shows resulting changes in chemical exposure rankings by body burden. Sensitivity analysis indicates that the model is sensitive to the air emissions rate of chemicals from products. <i>Ex Priori</i>’s simple dashboard facilitates dynamic exploration of the effects of varying consumer product use patterns on prioritization of chemicals based on potential exposures. <i>Ex Priori</i> can be a useful modeling and visualization tool to both novice and experienced exposure modelers and complement more computationally intensive population-based exposure models. |
| first_indexed | 2024-03-09T19:25:59Z |
| format | Article |
| id | doaj.art-95098bcc86ff41b6b969f9649fea6217 |
| institution | Directory Open Access Journal |
| issn | 2305-6304 |
| language | English |
| last_indexed | 2024-03-09T19:25:59Z |
| publishDate | 2022-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Toxics |
| spelling | doaj.art-95098bcc86ff41b6b969f9649fea62172023-11-24T02:57:13ZengMDPI AGToxics2305-63042022-09-01101056910.3390/toxics10100569Exposure Prioritization (<i>Ex Priori</i>): A Screening-Level High-Throughput Chemical Prioritization ToolHeidi F. Hubbard0Caroline L. Ring1Tao Hong2Cara C. Henning3Daniel A. Vallero4Peter P. Egeghy5Michael-Rock Goldsmith6ICF International, 2635 Meridian Parkway, Durham, NC 27713, USAChemical Characterization and Exposure Division, Center for Computational Toxicology and Exposure, Office of Research and Development, U.S. Environmental Protection Agency, Durham, NC 27713, USAICF International, 2635 Meridian Parkway, Durham, NC 27713, USAICF International, 2635 Meridian Parkway, Durham, NC 27713, USAChemical Characterization and Exposure Division, Center for Computational Toxicology and Exposure, Office of Research and Development, U.S. Environmental Protection Agency, Durham, NC 27713, USAChemical Characterization and Exposure Division, Center for Computational Toxicology and Exposure, Office of Research and Development, U.S. Environmental Protection Agency, Durham, NC 27713, USAChemical Characterization and Exposure Division, Center for Computational Toxicology and Exposure, Office of Research and Development, U.S. Environmental Protection Agency, Durham, NC 27713, USATo estimate potential chemical risk, tools are needed to prioritize potential exposures for chemicals with minimal data. Consumer product exposures are a key pathway, and variability in consumer use patterns is an important factor. We designed <i>Ex Priori</i>, a flexible dashboard-type screening-level exposure model, to rapidly visualize exposure rankings from consumer product use. <i>Ex Priori</i> is Excel-based. Currently, it is parameterized for seven routes of exposure for 1108 chemicals present in 228 consumer product types. It includes toxicokinetics considerations to estimate body burden. It includes a simple framework for rapid modeling of broad changes in consumer use patterns by product category. <i>Ex Priori</i> rapidly models changes in consumer user patterns during the COVID-19 pandemic and instantly shows resulting changes in chemical exposure rankings by body burden. Sensitivity analysis indicates that the model is sensitive to the air emissions rate of chemicals from products. <i>Ex Priori</i>’s simple dashboard facilitates dynamic exploration of the effects of varying consumer product use patterns on prioritization of chemicals based on potential exposures. <i>Ex Priori</i> can be a useful modeling and visualization tool to both novice and experienced exposure modelers and complement more computationally intensive population-based exposure models.https://www.mdpi.com/2305-6304/10/10/569high-throughput exposure modelingconsumer productsconsumer habits and practices |
| spellingShingle | Heidi F. Hubbard Caroline L. Ring Tao Hong Cara C. Henning Daniel A. Vallero Peter P. Egeghy Michael-Rock Goldsmith Exposure Prioritization (<i>Ex Priori</i>): A Screening-Level High-Throughput Chemical Prioritization Tool Toxics high-throughput exposure modeling consumer products consumer habits and practices |
| title | Exposure Prioritization (<i>Ex Priori</i>): A Screening-Level High-Throughput Chemical Prioritization Tool |
| title_full | Exposure Prioritization (<i>Ex Priori</i>): A Screening-Level High-Throughput Chemical Prioritization Tool |
| title_fullStr | Exposure Prioritization (<i>Ex Priori</i>): A Screening-Level High-Throughput Chemical Prioritization Tool |
| title_full_unstemmed | Exposure Prioritization (<i>Ex Priori</i>): A Screening-Level High-Throughput Chemical Prioritization Tool |
| title_short | Exposure Prioritization (<i>Ex Priori</i>): A Screening-Level High-Throughput Chemical Prioritization Tool |
| title_sort | exposure prioritization i ex priori i a screening level high throughput chemical prioritization tool |
| topic | high-throughput exposure modeling consumer products consumer habits and practices |
| url | https://www.mdpi.com/2305-6304/10/10/569 |
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