Efflux pump gene amplifications bypass necessity of multiple target mutations for resistance against dual-targeting antibiotic
Abstract Antibiotics that have multiple cellular targets theoretically reduce the frequency of resistance evolution, but adaptive trajectories and resistance mechanisms against such antibiotics are understudied. Here we investigate these in methicillin resistant Staphylococcus aureus (MRSA) using ex...
Main Authors: | Kalinga Pavan T. Silva, Ganesh Sundar, Anupama Khare |
---|---|
Format: | Article |
Language: | English |
Published: |
Nature Portfolio
2023-06-01
|
Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-023-38507-4 |
Similar Items
-
Efflux pumps as potential targets for biofilm inhibition
by: Jingyi Ren, et al.
Published: (2024-02-01) -
Bacterial Efflux Pump Inhibitors Reduce Antibiotic Resistance
by: Lan Zhang, et al.
Published: (2024-01-01) -
Multidrug Efflux Pumps in Bacteria and Efflux Pump Inhibitors
by: Sreekantan Abhirami P., et al.
Published: (2022-10-01) -
Non-antibiotics, Efflux Pumps and Drug Resistance of Gram-negative Rods
by: AGNIESZKA EWA LAUDY
Published: (2018-06-01) -
Multidrug efflux pumps at the crossroad between antibiotic resistance and bacterial virulence
by: Manuel Alcalde-Rico, et al.
Published: (2016-09-01)