Current epidemiology of diabetic retinopathy in patients with type 1 diabetes: a national multicenter study in Brazil
Abstract Background Diabetic retinopathy is the leading cause of blindness in economically active populations. The aims of this study were to estimate the prevalence and to identify risk factors for diabetic retinopathy in patients with type 1 diabetes in Brazil. Methods This was a nationwide, cross...
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| Format: | Article |
| Language: | English |
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BMC
2018-08-01
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| Series: | BMC Public Health |
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| Online Access: | http://link.springer.com/article/10.1186/s12889-018-5859-x |
| _version_ | 1818587722257793024 |
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| author | Laura Gomes Nunes Melo Paulo Henrique Morales Karla Rezende Guerra Drummond Deborah Conte Santos Marcela Haas Pizarro Bianca Senger Vasconcelos Barros Tessa Cerqueria Lemos Mattos André Araújo Pinheiro Felipe Mallmann Franz Schubert Lopes Leal Fernando Korn Malerbi Marilia Brito Gomes |
| author_facet | Laura Gomes Nunes Melo Paulo Henrique Morales Karla Rezende Guerra Drummond Deborah Conte Santos Marcela Haas Pizarro Bianca Senger Vasconcelos Barros Tessa Cerqueria Lemos Mattos André Araújo Pinheiro Felipe Mallmann Franz Schubert Lopes Leal Fernando Korn Malerbi Marilia Brito Gomes |
| author_sort | Laura Gomes Nunes Melo |
| collection | DOAJ |
| description | Abstract Background Diabetic retinopathy is the leading cause of blindness in economically active populations. The aims of this study were to estimate the prevalence and to identify risk factors for diabetic retinopathy in patients with type 1 diabetes in Brazil. Methods This was a nationwide, cross-sectional study conducted between August 2010 and August 2014. The study included 1760 patients with type 1 diabetes. Patients underwent a standard questionnaire, clinical and laboratory analyses and were screened for diabetic retinopathy. To analyze the risk factors related to diabetic retinopathy, two models of logistic regression models were performed, one considering vision-threatening cases and the other with any diabetic retinopathy cases as dependent variables. The group with vision-threatening included patients with severe non-proliferative diabetic retinopathy, proliferative diabetic retinopathy and macular edema. Results In total, 1644 patients (mean age, 30.1± 12.0 years; duration of diabetes, 15.3 ± 9.3 years; female, 55.8%) were studied. 35.7% presented diabetic retinopathy and 12% presented vision-threatening diabetic retinopathy. Three risk factors associated with diabetic retinopathy were in common to both groups: longer diabetes duration (OR 1.07; 95% CI, 1.05–1.09), higher levels of HbA1c (OR 1.24; CI, 1.17–1.32) and higher levels of serum uric acid (OR 1.22; CI, 1.13–1.31) (p < 0.001 for all comparisons). Conclusion The higher rate of vision-threatening retinopathy found in our study highlights the need to improve access to eye care and screening programs for diabetic retinopathy in Brazil. In addition to traditional risk factors, we found an association between serum uric acid levels and diabetic retinopathy. Further studies are needed to address this association. |
| first_indexed | 2024-12-16T09:13:22Z |
| format | Article |
| id | doaj.art-950bddd6f1d745ac8dbb3880732e2483 |
| institution | Directory Open Access Journal |
| issn | 1471-2458 |
| language | English |
| last_indexed | 2024-12-16T09:13:22Z |
| publishDate | 2018-08-01 |
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| series | BMC Public Health |
| spelling | doaj.art-950bddd6f1d745ac8dbb3880732e24832022-12-21T22:36:56ZengBMCBMC Public Health1471-24582018-08-011811910.1186/s12889-018-5859-xCurrent epidemiology of diabetic retinopathy in patients with type 1 diabetes: a national multicenter study in BrazilLaura Gomes Nunes Melo0Paulo Henrique Morales1Karla Rezende Guerra Drummond2Deborah Conte Santos3Marcela Haas Pizarro4Bianca Senger Vasconcelos Barros5Tessa Cerqueria Lemos Mattos6André Araújo Pinheiro7Felipe Mallmann8Franz Schubert Lopes Leal9Fernando Korn Malerbi10Marilia Brito Gomes11Department of Ophthalmology, State University of Rio de JaneiroDepartment of Ophthalmology, Federal University of São PauloDepartment of Ophthalmology, Hospital Federal dos Servidores do EstadoDepartment of Internal Medicine, Diabetes Unit, State University of Rio de JaneiroDepartment of Internal Medicine, Diabetes Unit, State University of Rio de JaneiroDepartment of Internal Medicine, Diabetes Unit, State University of Rio de JaneiroDepartment of Ophthalmology, Centro de Endocrinologia e Diabetes do Estado da BahiaDepartment of Ophthalmology, Hospital Regional de TaguatingaDepartment of Ophthalmology, Federal University of Rio Grande do SulDepartment of Ophthalmology, University of CampinasDepartment of Endocrinology and Ophthalmology, Federal University of São PauloDepartment of Internal Medicine, Diabetes Unit, State University of Rio de JaneiroAbstract Background Diabetic retinopathy is the leading cause of blindness in economically active populations. The aims of this study were to estimate the prevalence and to identify risk factors for diabetic retinopathy in patients with type 1 diabetes in Brazil. Methods This was a nationwide, cross-sectional study conducted between August 2010 and August 2014. The study included 1760 patients with type 1 diabetes. Patients underwent a standard questionnaire, clinical and laboratory analyses and were screened for diabetic retinopathy. To analyze the risk factors related to diabetic retinopathy, two models of logistic regression models were performed, one considering vision-threatening cases and the other with any diabetic retinopathy cases as dependent variables. The group with vision-threatening included patients with severe non-proliferative diabetic retinopathy, proliferative diabetic retinopathy and macular edema. Results In total, 1644 patients (mean age, 30.1± 12.0 years; duration of diabetes, 15.3 ± 9.3 years; female, 55.8%) were studied. 35.7% presented diabetic retinopathy and 12% presented vision-threatening diabetic retinopathy. Three risk factors associated with diabetic retinopathy were in common to both groups: longer diabetes duration (OR 1.07; 95% CI, 1.05–1.09), higher levels of HbA1c (OR 1.24; CI, 1.17–1.32) and higher levels of serum uric acid (OR 1.22; CI, 1.13–1.31) (p < 0.001 for all comparisons). Conclusion The higher rate of vision-threatening retinopathy found in our study highlights the need to improve access to eye care and screening programs for diabetic retinopathy in Brazil. In addition to traditional risk factors, we found an association between serum uric acid levels and diabetic retinopathy. Further studies are needed to address this association.http://link.springer.com/article/10.1186/s12889-018-5859-xRetinopathyEpidemiologyMicrovascular diseaseType1 diabetesVision-threateningRisk factors |
| spellingShingle | Laura Gomes Nunes Melo Paulo Henrique Morales Karla Rezende Guerra Drummond Deborah Conte Santos Marcela Haas Pizarro Bianca Senger Vasconcelos Barros Tessa Cerqueria Lemos Mattos André Araújo Pinheiro Felipe Mallmann Franz Schubert Lopes Leal Fernando Korn Malerbi Marilia Brito Gomes Current epidemiology of diabetic retinopathy in patients with type 1 diabetes: a national multicenter study in Brazil BMC Public Health Retinopathy Epidemiology Microvascular disease Type1 diabetes Vision-threatening Risk factors |
| title | Current epidemiology of diabetic retinopathy in patients with type 1 diabetes: a national multicenter study in Brazil |
| title_full | Current epidemiology of diabetic retinopathy in patients with type 1 diabetes: a national multicenter study in Brazil |
| title_fullStr | Current epidemiology of diabetic retinopathy in patients with type 1 diabetes: a national multicenter study in Brazil |
| title_full_unstemmed | Current epidemiology of diabetic retinopathy in patients with type 1 diabetes: a national multicenter study in Brazil |
| title_short | Current epidemiology of diabetic retinopathy in patients with type 1 diabetes: a national multicenter study in Brazil |
| title_sort | current epidemiology of diabetic retinopathy in patients with type 1 diabetes a national multicenter study in brazil |
| topic | Retinopathy Epidemiology Microvascular disease Type1 diabetes Vision-threatening Risk factors |
| url | http://link.springer.com/article/10.1186/s12889-018-5859-x |
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