Improving the therapy of generalized forms of Meningococcal infection in children using extracorporeal hemocorrection
Invasive meningococcal infection is a significant cause of death, reaching 80% in septic shock. The Pediatric Research and Clinical Center for Infectious Diseases (PRCCID) has developed an algorithm for the treatment of children with invasive meningococcal infection with refractory septic shock and...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | Russian |
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LLC "Diagnostics and Vaccines"
2021-07-01
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| Series: | Детские инфекции (Москва) |
| Subjects: | |
| Online Access: | https://detinf.elpub.ru/jour/article/view/599 |
| _version_ | 1797881783806590976 |
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| author | K. V. Markova E. Yu. Skripchenko K. V. Serednyakov Yu. V. Lobzin N. V. Skripchenko V. E. Karev A. N. Uskov A. A. Vilnits E. Yu. Gorelik |
| author_facet | K. V. Markova E. Yu. Skripchenko K. V. Serednyakov Yu. V. Lobzin N. V. Skripchenko V. E. Karev A. N. Uskov A. A. Vilnits E. Yu. Gorelik |
| author_sort | K. V. Markova |
| collection | DOAJ |
| description | Invasive meningococcal infection is a significant cause of death, reaching 80% in septic shock. The Pediatric Research and Clinical Center for Infectious Diseases (PRCCID) has developed an algorithm for the treatment of children with invasive meningococcal infection with refractory septic shock and multiple organ failure syndrome, which includes basic drug therapy with polymyxin hemoperfusion in combination with extended methods of extracorporeal hemocorrection.Purpose: to evaluate the effectiveness of extracorporeal hemocorrection operations in children with invasive meningococcal infection with refractory septic shock and multiple organ failure syndrome.Materials and research methods: to the intensive care unit of the PRCCID for the analyzed period 2006—2020 34 children were hospitalized with invasive meningococcal infection with refractory septic shock and multiple organ failure syndrome. Two groups were formed: Group 1 — children admitted to the PRCCID in the period 2014—2020 (n = 23), who underwent polymyxin hemoperfusion simultaneously with extended methods of extracorporeal hemocorrection, group 2 — children hospitalized in 2006—201 3 (n = 1 1), methods of extracorporeal hemocorrection were not performed. The Mann-Whitney U-test and ANOVA were used to evaluate the results.Results and discussion: the use of extracorporeal hemocorrection operations in the complex therapy of invasive forms of meningococcal infection with refractory septic shock and multiple organ failure syndrome in children provides stabilization of central hemodynamics, reduces clinical and laboratory inflammatory reactions, helps to reduce the dose of vasopressor drugs and parameters of respiratory support, and also increases patient survival rate by 82.6%. |
| first_indexed | 2024-04-10T03:24:33Z |
| format | Article |
| id | doaj.art-950cd7e179004ebd8a881a18cdf6a761 |
| institution | Directory Open Access Journal |
| issn | 2072-8107 |
| language | Russian |
| last_indexed | 2024-04-10T03:24:33Z |
| publishDate | 2021-07-01 |
| publisher | LLC "Diagnostics and Vaccines" |
| record_format | Article |
| series | Детские инфекции (Москва) |
| spelling | doaj.art-950cd7e179004ebd8a881a18cdf6a7612023-03-13T07:28:26ZrusLLC "Diagnostics and Vaccines"Детские инфекции (Москва)2072-81072021-07-01202495610.22627/2072-8107-2021-20-2-49-56504Improving the therapy of generalized forms of Meningococcal infection in children using extracorporeal hemocorrectionK. V. Markova0E. Yu. Skripchenko1K. V. Serednyakov2Yu. V. Lobzin3N. V. Skripchenko4V. E. Karev5A. N. Uskov6A. A. Vilnits7E. Yu. Gorelik8Детский научно-клинический центр инфекционных болезней Федерального медико-биологического агентстваДетский научно-клинический центр инфекционных болезней Федерального медико-биологического агентства; Санкт-Петербургский государственный педиатрический медицинский университет Министерства здравоохранения Российской ФедерацииДетский научно-клинический центр инфекционных болезней Федерального медико-биологического агентства; Санкт-Петербургский государственный педиатрический медицинский университет Министерства здравоохранения Российской ФедерацииДетский научно-клинический центр инфекционных болезней Федерального медико-биологического агентстваДетский научно-клинический центр инфекционных болезней Федерального медико-биологического агентства; Санкт-Петербургский государственный педиатрический медицинский университет Министерства здравоохранения Российской ФедерацииДетский научно-клинический центр инфекционных болезней Федерального медико-биологического агентстваДетский научно-клинический центр инфекционных болезней Федерального медико-биологического агентстваДетский научно-клинический центр инфекционных болезней Федерального медико-биологического агентства; Санкт-Петербургский государственный педиатрический медицинский университет Министерства здравоохранения Российской ФедерацииДетский научно-клинический центр инфекционных болезней Федерального медико-биологического агентстваInvasive meningococcal infection is a significant cause of death, reaching 80% in septic shock. The Pediatric Research and Clinical Center for Infectious Diseases (PRCCID) has developed an algorithm for the treatment of children with invasive meningococcal infection with refractory septic shock and multiple organ failure syndrome, which includes basic drug therapy with polymyxin hemoperfusion in combination with extended methods of extracorporeal hemocorrection.Purpose: to evaluate the effectiveness of extracorporeal hemocorrection operations in children with invasive meningococcal infection with refractory septic shock and multiple organ failure syndrome.Materials and research methods: to the intensive care unit of the PRCCID for the analyzed period 2006—2020 34 children were hospitalized with invasive meningococcal infection with refractory septic shock and multiple organ failure syndrome. Two groups were formed: Group 1 — children admitted to the PRCCID in the period 2014—2020 (n = 23), who underwent polymyxin hemoperfusion simultaneously with extended methods of extracorporeal hemocorrection, group 2 — children hospitalized in 2006—201 3 (n = 1 1), methods of extracorporeal hemocorrection were not performed. The Mann-Whitney U-test and ANOVA were used to evaluate the results.Results and discussion: the use of extracorporeal hemocorrection operations in the complex therapy of invasive forms of meningococcal infection with refractory septic shock and multiple organ failure syndrome in children provides stabilization of central hemodynamics, reduces clinical and laboratory inflammatory reactions, helps to reduce the dose of vasopressor drugs and parameters of respiratory support, and also increases patient survival rate by 82.6%.https://detinf.elpub.ru/jour/article/view/599менингококковая инфекцияn. meningitidisрефрактерный септический шоксиндром полиорганной недостаточностиэкстракорпоральная терапияполимиксиновая гемоперфузиядети |
| spellingShingle | K. V. Markova E. Yu. Skripchenko K. V. Serednyakov Yu. V. Lobzin N. V. Skripchenko V. E. Karev A. N. Uskov A. A. Vilnits E. Yu. Gorelik Improving the therapy of generalized forms of Meningococcal infection in children using extracorporeal hemocorrection Детские инфекции (Москва) менингококковая инфекция n. meningitidis рефрактерный септический шок синдром полиорганной недостаточности экстракорпоральная терапия полимиксиновая гемоперфузия дети |
| title | Improving the therapy of generalized forms of Meningococcal infection in children using extracorporeal hemocorrection |
| title_full | Improving the therapy of generalized forms of Meningococcal infection in children using extracorporeal hemocorrection |
| title_fullStr | Improving the therapy of generalized forms of Meningococcal infection in children using extracorporeal hemocorrection |
| title_full_unstemmed | Improving the therapy of generalized forms of Meningococcal infection in children using extracorporeal hemocorrection |
| title_short | Improving the therapy of generalized forms of Meningococcal infection in children using extracorporeal hemocorrection |
| title_sort | improving the therapy of generalized forms of meningococcal infection in children using extracorporeal hemocorrection |
| topic | менингококковая инфекция n. meningitidis рефрактерный септический шок синдром полиорганной недостаточности экстракорпоральная терапия полимиксиновая гемоперфузия дети |
| url | https://detinf.elpub.ru/jour/article/view/599 |
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